中国长期臭氧暴露与肺癌发病率:基于全国人群队列的数据(中国心脏研究中心)

IF 9.4 Q1 ONCOLOGY
Yi Wu , Chunqi Wang , Chunxiao Xu , Siming Wang , Rongshou Zheng , Chunying Lin , Xiaoyan Zhang , Bowang Chen , Yang Yang , Wei Li , Guangda He , Jianlan Cui , Wei Xu , Lijuan Song , Hao Yang , Wenyan He , Yan Zhang , Jing Wei , Tiantian Li , Xi Li
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引用次数: 0

摘要

臭氧(O3)被认为是造成全球疾病负担的主要且日益普遍的气态污染物。然而,它对肺癌发展的影响尚未得到充分承认。方法基于健康评估和通过全国团队合作降低风险(ChinaHEART),这是一项全国性的、基于人群的队列研究,生活在20,159个社区或村庄的2,006,878名参与者通过与国家中央癌症登记处的数据联系进行肺癌发病率的被动随访。各地区自入学之年起十年的平均臭氧水平是根据地理坐标确定的。我们采用Cox比例风险回归模型来评估O3暴露与肺癌发展之间的独立风险比(hr)。结果在493万人年的随访中,发现4555例肺癌新发病例。在调整参与者特征和其他环境因素后,我们观察到环境O3暴露与肺癌之间存在显著的正相关。与O3四分位数1的参与者相比,其他三个四分位数的hr和95%置信区间(CI)分别为1.09 (95% CI: 1.00-1.17)、1.17 (95% CI: 1.06-1.29)和1.42 (95% CI: 1.26-1.59)。结论:长期暴露于环境中O3与肺癌风险显著增加相关。需要进一步研究以探索其致病机制,并评估在个人或群体层面上保护暴露或减轻危害的措施。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Long-term exposure to ozone and incidence of lung cancer in China: data based on a national population cohort (ChinaHEART)

Objective

Ozone (O3) is recognized as a predominant and increasingly prevalent gaseous pollutant contributing to the Global Burden of Disease. However, its effect on the development of lung cancer has not been adequately acknowledged.

Methods

Based on Health Evaluation And risk Reduction through nationwide Teamwork (ChinaHEART), a nationwide, population-based cohort study, 2,006,878 participants living in 20,159 communities or villages were passively followed for the incidence of lung cancer through a linkage of data with the National Central Cancer Registry. The average O3 levels over ten years from the year of enrolment in their respective localities were determined based on geographic coordinates. We conducted Cox proportional-hazards regression models to assess the independent hazard ratios (HRs) associated with O3 exposure and the development of lung cancer.

Results

During the follow-up of 4.93 million person-years, 4555 new cases of lung cancer were identified. After adjusting for participant characteristics and other environmental factors, we observed a significant positive association between ambient O3 exposure and lung cancer. Compared with participants in the quartile 1 of O3, HRs and 95 % confidence intervals (CI) for the other three quartiles were 1.09 (95 % CI: 1.00–1.17), 1.17 (95 % CI: 1.06–1.29) and 1.42 (95 % CI: 1.26–1.59), respectively.

Conclusions

Long-term exposure to ambient O3 is associated with a substantially higher risk of lung cancer. Further studies are needed to explore its pathogenic mechanisms, as well as to evaluate measures for exposure protection or harm mitigation at the individual or population level.
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