金催化双酯系脲环化高效合成2-氨基- 4h -吡喃

IF 4.2 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemical Communications Pub Date : 2025-09-29 DOI:10.1039/d5cc04409j

Jianfeng Zheng, Dong Xiong, Yongqi Ye, Luhao Tang, Jiajin Yang, Zeyu Yang, Yunfei Cai

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引用次数: 0

摘要

本文报道了金催化的二酯系脲分子内环化反应。该工艺具有官能团容忍度高、底物范围广、原子经济性100%等特点。在0.5 ~ 5 mol%的催化剂负载下，得到了多种功能化的2-氨基- 4h -吡喃类化合物，收率高达95%。该反应可以按比例放大，也可以进行下游转化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Efficient syntheses of 2-amino-4H-pyrans via gold-catalyzed cyclization of diester-tethered ynamides

Gold-catalyzed intramolecular cyclizations of diester-tethered ynamides are reported herein. This protocol exhibited a high functional group tolerance, broad substrate scope and 100% atom economy. A variety of functionalized 2-amino-4H-pyrans were obtained in up to 95% yield with 0.5-5 mol% catalyst loading. The reaction could be scaled-up and downstream transformations were also performed.

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来源期刊

Chemical Communications 化学-化学综合

CiteScore

8.60

自引率

4.10%

发文量

2705

审稿时长

1.4 months

期刊介绍： ChemComm (Chemical Communications) is renowned as the fastest publisher of articles providing information on new avenues of research, drawn from all the world''s major areas of chemical research.