脑小血管疾病中神经退行性蛋白与脑铁沉积和认知的关联:定量易感性图谱和血浆生物标志物研究

IF 11.1 1区 医学 Q1 CLINICAL NEUROLOGY
Yiwen Chen, Meng Li, Jing Li, Pengcheng Liang, Zhenyu Cheng, Na Wang, Xinyue Zhang, Yuanyuan Wang, Nan Zhang, Yena Che, Wenwen Gao, Lingfei Guo, Changhu Liang
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引用次数: 0

摘要

脑血管病(CSVD)是一种常见的神经系统疾病,常规磁共振成像病理有限。本研究使用定量易感性制图(QSM)研究脑铁、血浆神经退行性蛋白和认知在CSVD中的联系。方法本研究纳入319例CSVD患者,分为CSVD‐M组和CSVD‐S组。对178名参与者的血浆蛋白进行了测量,其中80人在2年后接受了随访。基于QSM的体素分析评估了脑铁、CSVD严重程度和蛋白质相关性。交叉滞后面板模型用于分析血浆蛋白水平和脑铁水平之间的时间相关性。结果在CSVD‐S中,右侧罗兰底盖/颞上回QSM值升高与血浆Aβ42和执行功能呈负相关。a - β42也与皮层区域的QSM负相关,与情景记忆衰退有关。较高的基线Aβ40预测随访时左壳核QSM增加。血浆Aβ42和Aβ40可能驱动CSVD患者脑铁沉积和认知障碍,可作为疾病进展的潜在早期生物标志物。QSM揭示了脑铁与心血管疾病认知中的Aβ42的联系。血浆Aβ42与运动和额叶区的铁相关。高Aβ40预测CSVD随访时壳核铁升高。铁沉积与心血管疾病的执行力和记忆力缺陷有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Associations of neurodegenerative proteins with brain iron deposition and cognition in cerebral small vessel disease: a quantitative susceptibility mapping and plasma biomarker study

INTRODUCTION

Cerebral small vessel disease (CSVD) is a common neurological disorder with limited pathology on conventional magnetic resonance imaging. This study uses quantitative susceptibility mapping (QSM) to investigate links among brain iron, plasma neurodegenerative proteins, and cognition in CSVD.

METHODS

This study enrolled 319 CSVD patients, grouped into CSVD-M and CSVD-S. Plasma proteins were measured in 178 participants, with 80 being followed up after 2 years. QSM-based voxel-wise analysis assessed brain iron, CSVD severity, and protein correlations. A cross-lagged panel model was used to analyze the temporal association between plasma protein levels and brain iron levels.

RESULTS

In CSVD-S, elevated QSM values in the right Rolandic operculum/superior temporal gyrus negatively correlated with plasma Aβ42 and executive function. Aβ42 also negatively correlated with QSM in cortical regions, tied to episodic memory decline. Higher baseline Aβ40 predicted increased QSM in the left putamen at follow-up.

DISCUSSION

Plasma Aβ42 and Aβ40 may drive brain iron deposition and cognitive impairment in CSVD, serving as potential early biomarkers for disease progression.

Highlights

  • QSM reveals brain iron links to Aβ42, cognition in CSVD.
  • Plasma Aβ42 correlates with iron in motor and frontal areas.
  • High Aβ40 predicts putamen iron increase in CSVD follow-up.
  • Iron deposition is tied to executive, memory deficits in CSVD.
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来源期刊
Alzheimer's & Dementia
Alzheimer's & Dementia 医学-临床神经学
CiteScore
14.50
自引率
5.00%
发文量
299
审稿时长
3 months
期刊介绍: Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.
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