下一代癌症疫苗:用于精确免疫治疗的隐抗原和非典型抗原

Q3 Medicine
Exploration of targeted anti-tumor therapy Pub Date : 2025-09-25 eCollection Date: 2025-01-01 DOI:10.37349/etat.2025.1002338
Anu Shibi Anilkumar, Sheena Mariam Thomas, Ramakrishnan Veerabathiran
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引用次数: 0

摘要

癌症免疫疗法通过利用免疫系统靶向肿瘤细胞,彻底改变了肿瘤学。引发肿瘤特异性免疫反应的癌症疫苗在新方法中越来越受欢迎。然而,传统的肿瘤相关抗原易受免疫耐受影响,往往表现出低免疫原性。本文综述了隐抗原和非典型抗原作为精确免疫治疗新靶点的革命性潜力。由于其增强的肿瘤选择性和逃避中枢耐受的能力,这些非常规抗原为疫苗开发提供了令人鼓舞的选择。本文综述了它们的抗原产生机制、发现它们的先进技术和各种疫苗平台,强调了它们推动下一代癌症疫苗的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Next-generation cancer vaccines: targeting cryptic and non-canonical antigens for precision immunotherapy.

Next-generation cancer vaccines: targeting cryptic and non-canonical antigens for precision immunotherapy.

Next-generation cancer vaccines: targeting cryptic and non-canonical antigens for precision immunotherapy.

Next-generation cancer vaccines: targeting cryptic and non-canonical antigens for precision immunotherapy.

Cancer immunotherapy has revolutionized oncology by harnessing the immune system to target tumor cells. Cancer vaccines that trigger immune responses specific to tumors are becoming more and more popular among new approaches. Nevertheless, traditional tumour-associated antigens are susceptible to immune tolerance and frequently show low immunogenicity. The revolutionary potential of cryptic and non-canonical antigens as new targets for precision immunotherapy is examined in this review. Due to their enhanced tumor selectivity and ability to evade central tolerance, these unconventional antigens present encouraging options for vaccine development. This review examines the mechanisms underlying their antigen production, advanced technologies for their discovery, and various vaccine platforms, highlighting their potential to drive the next generation of cancer vaccines.

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来源期刊
CiteScore
2.80
自引率
0.00%
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审稿时长
13 weeks
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