从实验台到人体:保护性念珠菌特异性单克隆抗体显示体内和转化潜力。

Hong Xin
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引用次数: 0

摘要

耳念珠菌是一种多重耐药真菌病原体,对全球健康构成日益严峻的挑战,特别是由于它能够在脆弱患者中引起侵入性血液和深层感染。基于单克隆抗体(mAb)的免疫治疗为克服当前抗真菌治疗的局限性提供了一种新的靶向方法。这篇评论强调了念珠菌特异性单克隆抗体C3.1、6H1和9F2对体内播散性念珠菌病小鼠模型的保护作用。这些抗体针对不同的、保守的表面抗原,显著减少真菌负担,同时提高生存结果。它们的翻译潜力在于它们的特异性、低毒性和增强宿主免疫反应的能力,使它们成为未来发展作为人类侵袭性真菌感染的辅助或替代疗法的强有力候选者。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
From Bench to Body: Protective Candida-specific Monoclonal Antibodies Show In vivo and Translational Potential.

Candida auris is a multidrug-resistant fungal pathogen that presents a growing global health challenge, particularly due to its ability to cause invasive bloodstream and deep-seated infections in vulnerable patients. Monoclonal antibody (mAb)-based immunotherapy offers a novel and targeted approach to overcoming the limitations of current antifungal treatments. This commentary highlights the protective efficacy of Candida-specific mAbs, C3.1, 6H1, and 9F2, in in vivo mouse models of disseminated candidiasis. These antibodies target distinct, conserved surface antigens and significantly reduce fungal burden while improving survival outcomes. Their translational potential lies in their specificity, low toxicity, and ability to enhance host immune responses, making them strong candidates for future development as adjunct or alternative therapies for invasive fungal infections in humans.

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