慢性丙型肝炎直接抗病毒治疗治愈后骨微结构和炎症细胞因子的变化。

IF 3.8 4区 医学 Q2 IMMUNOLOGY
Open Forum Infectious Diseases Pub Date : 2025-09-15 eCollection Date: 2025-09-01 DOI:10.1093/ofid/ofaf571
Vincent Lo Re, Dean M Carbonari, Craig W Newcomb, Jessie Torgersen, Erica J Weinstein, Shanae M Smith, Katherine L Brecker, X Sherry Liu, Jay R Kostman, Stacey Trooskin, Rebecca A Hubbard, Joshua F Baker, Babette S Zemel, Mary B Leonard
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引用次数: 0

摘要

背景:目前尚不清楚使用直接作用抗病毒药物(DAAs)治疗丙型肝炎病毒(HCV)感染是否能改善丙型肝炎相关炎症和骨缺损。我们通过高分辨率外周定量计算机断层扫描(HR-pQCT)评估了DAA治疗前和开始治疗18个月后细胞因子和骨骼测量的变化,并比较了未感染对照组在18个月内的变化。方法:我们进行了一项队列研究,包括40名接受DAAs治疗并获得治愈的参与者和48名未感染HCV的参与者作为对照。在入组时和18个月后,通过HR-pQCT测量参与者的体积骨矿物质密度、皮质尺寸和桡骨和胫骨的力学特性;全身双能x线吸收仪测定内脏脂肪面积和阑尾瘦质量;血清肿瘤坏死因子α (TNF-α)、白细胞介素6 (IL-6)、白细胞介素18 (IL-18)。使用多变量线性回归来估计骨测量和细胞因子平均变化的组间差异。结果:我们观察到,在未调整模型中,治愈HCV的参与者和对照组在0-18个月的HR-pQCT测量值变化无显著差异,或在调整年龄、性别、阑尾瘦质量指数、内脏脂肪面积和吸烟后。与对照组相比,HCV治愈的参与者IL-18(平均变化,-0.085 vs +0.086 log pg/mL, P < 0.001)和TNF-α(平均变化,-0.050 vs +0.084 log pg/mL, P < 0.001)下降,但IL-6(平均变化,+0.108 vs +0.009 log pg/mL, P = 0.214)没有下降。结论:与对照组相比,HCV治愈的参与者在DAA开始18个月后的HR-pQCT中骨微结构没有显著变化,但IL-18和TNF-α与对照组相比确实有所下降。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Changes in Bone Microarchitecture and Inflammatory Cytokines After Cure of Chronic Hepatitis C Infection With Direct-Acting Antiviral Therapy.

Background: It remains unclear if cure of hepatitis C virus (HCV) infection with direct-acting antivirals (DAAs) ameliorates HCV-related inflammation and bone deficits. We evaluated changes in cytokines and bone measurements by high-resolution peripheral quantitative computed tomography (HR-pQCT) prior to DAA treatment and 18 months following initiation and compared changes in uninfected controls over 18 months.

Methods: We conducted a cohort study of 40 participants who initiated DAAs and achieved cure and 48 without HCV as controls. At enrollment and 18 months later, participants had measurements of volumetric bone mineral density, cortical dimensions, and mechanical properties of the radius and tibia by HR-pQCT; visceral fat area and appendicular lean mass by whole-body dual-energy X-ray absorptiometry; and serum tumor necrosis factor alpha (TNF-α), interleukin 6 (IL-6), and interleukin 18 (IL-18). Multivariable linear regression was used to estimate group differences in mean changes in bone measurements and cytokines.

Results: We observed no significant differences in month 0-18 changes in HR-pQCT measurements between participants with cured HCV and controls in unadjusted models or after adjustment for age, sex, appendicular lean mass index, visceral fat area, and smoking. Participants with cured HCV had decreases in IL-18 (mean change, -0.085 vs +0.086 log pg/mL; P < .001) and TNF-α (mean change, -0.050 vs +0.084 log pg/mL; P < .001), but not IL-6 (mean change, +0.108 vs +0.009 log pg/mL; P = .214) versus controls.

Conclusions: Participants with cured HCV had no significant changes in bone microarchitecture by HR-pQCT 18 months after DAA initiation compared with controls, but did have decreases in IL-18 and TNF-α versus controls.

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来源期刊
Open Forum Infectious Diseases
Open Forum Infectious Diseases Medicine-Neurology (clinical)
CiteScore
6.70
自引率
4.80%
发文量
630
审稿时长
9 weeks
期刊介绍: Open Forum Infectious Diseases provides a global forum for the publication of clinical, translational, and basic research findings in a fully open access, online journal environment. The journal reflects the broad diversity of the field of infectious diseases, and focuses on the intersection of biomedical science and clinical practice, with a particular emphasis on knowledge that holds the potential to improve patient care in populations around the world. Fully peer-reviewed, OFID supports the international community of infectious diseases experts by providing a venue for articles that further the understanding of all aspects of infectious diseases.
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