胰腺外分泌功能不全定义的演变-对临床诊断和治疗的意义。

IF 4 4区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY
Ana García García de Paredes, Juan Enrique Domínguez Muñoz
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引用次数: 0

摘要

胰腺外分泌功能不全(PEI)是一种由腔内胰腺酶活性不足引起的消化不良综合征,导致营养缺乏和生活质量受损。最近的欧洲指南重新定义了PEI,认为它是一种多因素疾病,不仅限于胰腺分泌减少,还涉及各种临床情况下的功能性消化衰竭,包括胰腺和非胰腺疾病。这篇社论回顾了这一修订定义对临床实践的关键意义,强调基于临床背景、胰腺功能测试、症状和营养指标的综合诊断方法。此外,它强调了合理处方胰酶替代疗法(PERT)的重要性,旨在优化患者的预后,同时避免不必要的治疗。这种对PEI的更新观点促进了更准确的诊断、靶向治疗和改进的医疗资源分配。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The evolving definition of pancreatic exocrine insufficiency ‒ Implications for diagnosis and treatment in clinical practice.

Pancreatic exocrine insufficiency (PEI) is a syndrome of maldigestion caused by insufficient intraluminal pancreatic enzyme activity, leading to nutritional deficiencies and impaired quality of life. Recent European guidelines have redefined PEI, recognizing it as a multifactorial condition not limited to reduced pancreatic secretion, but also involving functional digestive failure in various clinical contexts, including pancreatic and non-pancreatic diseases. This editorial reviews the key implications of this revised definition for clinical practice, emphasizing a comprehensive diagnostic approach based on clinical context, pancreatic function tests, symptoms, and nutritional markers. Furthermore, it underscores the importance of rational prescription of pancreatic enzyme replacement therapy (PERT), aiming to optimize patient outcomes while avoiding unnecessary treatment. This updated perspective on PEI promotes more accurate diagnosis, targeted therapy, and improved healthcare resource allocation.

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来源期刊
CiteScore
2.00
自引率
25.00%
发文量
400
审稿时长
6-12 weeks
期刊介绍: La Revista Española de Enfermedades Digestivas, Órgano Oficial de la Sociedad Española de Patología Digestiva (SEPD), Sociedad Española de Endoscopia Digestiva (SEED) y Asociación Española de Ecografía Digestiva (AEED), publica artículos originales, editoriales, revisiones, casos clínicos, cartas al director, imágenes en patología digestiva, y otros artículos especiales sobre todos los aspectos relativos a las enfermedades digestivas.
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