Prachi Sharma, Nivya George, Deokumar Srivastava, Eric J Chow, Melissa A Alderfer, Wendy Leisenring, Kristin A Long, Anne E Lown, Kevin C Oeffinger, Lonnie K Zeltzer, Gregory T Armstrong, Kevin R Krull, Tara M Brinkman, David Buchbinder
{"title":"失去亲人的兄弟姐妹的心理社会健康和慢性健康状况：来自儿童癌症生存研究（CCSS）的报告。","authors":"Prachi Sharma, Nivya George, Deokumar Srivastava, Eric J Chow, Melissa A Alderfer, Wendy Leisenring, Kristin A Long, Anne E Lown, Kevin C Oeffinger, Lonnie K Zeltzer, Gregory T Armstrong, Kevin R Krull, Tara M Brinkman, David Buchbinder","doi":"10.1002/pbc.32076","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To compare psychosocial health and chronic health conditions (CHCs) in bereaved and non-bereaved adult siblings impacted by childhood cancer and to identify predictors of emotional distress and health-related quality of life among bereaved siblings.</p><p><strong>Methods: </strong>A total of 4558 adult siblings (733 bereaved; 3825 non-bereaved) of 5-year survivors of childhood cancer completed measures of emotional distress (Brief Symptom Inventory [BSI]-18) and health-related quality of life (Medical Outcomes Survey Short Form [SF]-36) and reported their social attainment milestones (i.e., educational attainment, employment, and marital status). CHCs' burden was classified as none/low versus medium/high/very severe. Cancer-associated complications prior to the patient's death, sibling age at bereavement, and social attainment variables were examined as predictors of emotional distress and health-related quality of life among bereaved siblings using multivariable modified Poisson regression.</p><p><strong>Results: </strong>Bereaved siblings in this sample reported excellent psychosocial health long term (e.g., depressive symptoms 6.5%, somatization 4.4%, anxiety 3.5%). Bereaved siblings had an elevated risk of depression (relative risk [RR] 1.53; 1.10-2.13, p = 0.01), reduced social quality of life (RR 1.35; 1.00-1.82, p = 0.05), diminished educational attainment, and greater CHC burden than non-bereaved siblings. No differences were observed for other subscales or social attainment outcomes. Among bereaved siblings, risk factors for depression included male sex (RR 0.42; 0.19-0.93, p = 0.05), never being married (RR 3.02; 1.45-6.28, p = 0.05), and greater CHC burden (RR 2.42; 1.18-4.99, p = 0.05). Risk factors for poor social functioning included unemployment (RR 2.24; 1.12-4.45, p = 0.05) and never being married (RR 2.16; 1.22-3.82, p = 0.05).</p><p><strong>Conclusion: </strong>Bereaved siblings report excellent psychosocial health long-term and demonstrate only a marginally elevated risk of experiencing symptoms of depression and poor social quality of life compared to non-bereaved siblings.</p>","PeriodicalId":19822,"journal":{"name":"Pediatric Blood & Cancer","volume":" ","pages":"e32076"},"PeriodicalIF":2.3000,"publicationDate":"2025-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Psychosocial Health and Chronic Health Conditions Among Bereaved Siblings: A Report From the Childhood Cancer Survivorship Study (CCSS).\",\"authors\":\"Prachi Sharma, Nivya George, Deokumar Srivastava, Eric J Chow, Melissa A Alderfer, Wendy Leisenring, Kristin A Long, Anne E Lown, Kevin C Oeffinger, Lonnie K Zeltzer, Gregory T Armstrong, Kevin R Krull, Tara M Brinkman, David Buchbinder\",\"doi\":\"10.1002/pbc.32076\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To compare psychosocial health and chronic health conditions (CHCs) in bereaved and non-bereaved adult siblings impacted by childhood cancer and to identify predictors of emotional distress and health-related quality of life among bereaved siblings.</p><p><strong>Methods: </strong>A total of 4558 adult siblings (733 bereaved; 3825 non-bereaved) of 5-year survivors of childhood cancer completed measures of emotional distress (Brief Symptom Inventory [BSI]-18) and health-related quality of life (Medical Outcomes Survey Short Form [SF]-36) and reported their social attainment milestones (i.e., educational attainment, employment, and marital status). CHCs' burden was classified as none/low versus medium/high/very severe. Cancer-associated complications prior to the patient's death, sibling age at bereavement, and social attainment variables were examined as predictors of emotional distress and health-related quality of life among bereaved siblings using multivariable modified Poisson regression.</p><p><strong>Results: </strong>Bereaved siblings in this sample reported excellent psychosocial health long term (e.g., depressive symptoms 6.5%, somatization 4.4%, anxiety 3.5%). Bereaved siblings had an elevated risk of depression (relative risk [RR] 1.53; 1.10-2.13, p = 0.01), reduced social quality of life (RR 1.35; 1.00-1.82, p = 0.05), diminished educational attainment, and greater CHC burden than non-bereaved siblings. No differences were observed for other subscales or social attainment outcomes. Among bereaved siblings, risk factors for depression included male sex (RR 0.42; 0.19-0.93, p = 0.05), never being married (RR 3.02; 1.45-6.28, p = 0.05), and greater CHC burden (RR 2.42; 1.18-4.99, p = 0.05). Risk factors for poor social functioning included unemployment (RR 2.24; 1.12-4.45, p = 0.05) and never being married (RR 2.16; 1.22-3.82, p = 0.05).</p><p><strong>Conclusion: </strong>Bereaved siblings report excellent psychosocial health long-term and demonstrate only a marginally elevated risk of experiencing symptoms of depression and poor social quality of life compared to non-bereaved siblings.</p>\",\"PeriodicalId\":19822,\"journal\":{\"name\":\"Pediatric Blood & Cancer\",\"volume\":\" \",\"pages\":\"e32076\"},\"PeriodicalIF\":2.3000,\"publicationDate\":\"2025-09-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Pediatric Blood & Cancer\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1002/pbc.32076\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"HEMATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pediatric Blood & Cancer","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/pbc.32076","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"HEMATOLOGY","Score":null,"Total":0}
引用次数: 0
摘要
目的：比较受儿童癌症影响的失去亲人和未失去亲人的成年兄弟姐妹的心理社会健康和慢性健康状况（CHCs），并确定失去亲人的兄弟姐妹中情绪困扰和健康相关生活质量的预测因素。方法：共有4558名5年儿童癌症幸存者的成年兄弟姐妹（733名丧偶，3825名非丧偶）完成了情绪困扰（简短症状量表[BSI]-18）和健康相关生活质量（医疗结果调查短表[SF]-36）的测量，并报告了他们的社会成就里程碑（即教育程度、就业和婚姻状况）。CHCs的负担分为无/低与中/高/非常严重。使用多变量修正泊松回归，研究了患者死亡前的癌症相关并发症、丧亲兄弟姐妹的年龄和社会成就变量作为丧亲兄弟姐妹情绪困扰和健康相关生活质量的预测因素。结果：本样本中丧失亲人的兄弟姐妹报告了良好的长期心理健康状况（例如，抑郁症状6.5%，躯体化4.4%，焦虑3.5%）。丧亲的兄弟姐妹抑郁风险升高（相对风险[RR] 1.53; 1.10-2.13, p = 0.01），社会生活质量降低（RR 1.35; 1.00-1.82, p = 0.05），受教育程度降低，CHC负担高于未丧亲的兄弟姐妹。其他子量表或社会成就结果没有观察到差异。丧偶兄弟姐妹中，男性（RR = 0.42; 0.19-0.93, p = 0.05）、未婚（RR = 3.02; 1.45-6.28, p = 0.05）、CHC负担加重（RR = 2.42; 1.18-4.99, p = 0.05）是患抑郁症的危险因素。社会功能不良的危险因素包括失业（RR 2.24; 1.12-4.45, p = 0.05）和未婚（RR 2.16; 1.22-3.82, p = 0.05）。结论：失去亲人的兄弟姐妹报告了良好的长期心理健康状况，与没有失去亲人的兄弟姐妹相比，只有轻微增加的经历抑郁症状和社会生活质量差的风险。
Psychosocial Health and Chronic Health Conditions Among Bereaved Siblings: A Report From the Childhood Cancer Survivorship Study (CCSS).
Objective: To compare psychosocial health and chronic health conditions (CHCs) in bereaved and non-bereaved adult siblings impacted by childhood cancer and to identify predictors of emotional distress and health-related quality of life among bereaved siblings.
Methods: A total of 4558 adult siblings (733 bereaved; 3825 non-bereaved) of 5-year survivors of childhood cancer completed measures of emotional distress (Brief Symptom Inventory [BSI]-18) and health-related quality of life (Medical Outcomes Survey Short Form [SF]-36) and reported their social attainment milestones (i.e., educational attainment, employment, and marital status). CHCs' burden was classified as none/low versus medium/high/very severe. Cancer-associated complications prior to the patient's death, sibling age at bereavement, and social attainment variables were examined as predictors of emotional distress and health-related quality of life among bereaved siblings using multivariable modified Poisson regression.
Results: Bereaved siblings in this sample reported excellent psychosocial health long term (e.g., depressive symptoms 6.5%, somatization 4.4%, anxiety 3.5%). Bereaved siblings had an elevated risk of depression (relative risk [RR] 1.53; 1.10-2.13, p = 0.01), reduced social quality of life (RR 1.35; 1.00-1.82, p = 0.05), diminished educational attainment, and greater CHC burden than non-bereaved siblings. No differences were observed for other subscales or social attainment outcomes. Among bereaved siblings, risk factors for depression included male sex (RR 0.42; 0.19-0.93, p = 0.05), never being married (RR 3.02; 1.45-6.28, p = 0.05), and greater CHC burden (RR 2.42; 1.18-4.99, p = 0.05). Risk factors for poor social functioning included unemployment (RR 2.24; 1.12-4.45, p = 0.05) and never being married (RR 2.16; 1.22-3.82, p = 0.05).
Conclusion: Bereaved siblings report excellent psychosocial health long-term and demonstrate only a marginally elevated risk of experiencing symptoms of depression and poor social quality of life compared to non-bereaved siblings.
期刊介绍：
Pediatric Blood & Cancer publishes the highest quality manuscripts describing basic and clinical investigations of blood disorders and malignant diseases of childhood including diagnosis, treatment, epidemiology, etiology, biology, and molecular and clinical genetics of these diseases as they affect children, adolescents, and young adults. Pediatric Blood & Cancer will also include studies on such treatment options as hematopoietic stem cell transplantation, immunology, and gene therapy.
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