诊断为小脑性缄默症综合征的儿童患者的神经学、神经心理学和社会预后:一项系统综述。

IF 2.3 3区 医学 Q2 HEMATOLOGY
Margaret H Hughes, Joseph Giuseppe R Paturzo, Callie M Fernandez, Kareena S Garg, Jincy Rajan, Suditi Rahematpura, John R DiBello, Umayr R Shaikh, Jordan E Wrigley, Nicholas S Philips, Darcy Raches, Melissa M Hudson, Supriya Sarvode
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引用次数: 0

摘要

背景:小脑性缄默综合征(CMS)是后颅窝肿瘤切除术后的并发症。本综述探讨了患有CMS的儿童的长期神经学、神经心理学和社会结果。方法:在多个数据库中进行搜索,重点关注与肿瘤、术后并发症和缄默症相关的术语。所选的研究包括年龄小于18岁的个体,他们在后颅窝肿瘤切除后出现CMS,并至少出现一种神经学、神经心理学或社会结果。结果:在2514篇文献中,纳入34项研究,涉及631例年龄在1-25.7岁的患者(中位数为12例,范围为5-107例)。CMS患病率3.7% ~ 63%,中位随访26.5个月(2个月~ 14.2年)。在17项研究中,共济失调是最常见的神经系统预后。九项评估认知结果的研究中有五项发现CMS患者的全面智商/一般智力得分显著降低。在23项研究中,40%-100%的参与者都观察到了情绪变化。结论:CMS幸存者面临着持续的神经学、神经心理学和行为方面的挑战,影响了他们的生活质量,强调了手术技术和康复干预的进步。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Neurological, Neuropsychological, and Social Outcomes in Pediatric Patients Diagnosed With Cerebellar Mutism Syndrome: A Systematic Review.

Background: Cerebellar mutism syndrome (CMS) is a postsurgical complication following posterior fossa tumor resection. This review explores long-term neurological, neuropsychological, and social outcomes of children with CMS.

Methods: A search was performed across multiple databases, focusing on terms related to neoplasms, postoperative complications, and mutism. Selected studies included individuals less than 18 years of age who developed CMS following posterior fossa tumor removal, and developed at least one neurological, neuropsychological, or social outcome.

Results: Among 2514 publications, 34 studies were included, describing 631 patients aged 1-25.7 years (median = 12 patients; range: 5-107 patients). The prevalence of CMS ranged from 3.7% to 63%, with a median follow-up of 26.5 months (ranging from 2 months to 14.2 years). Ataxia was the most common neurologic outcome reported in 17 studies. Five of nine studies assessing cognitive outcomes noted significantly lower full-scale intelligence quotient/general intellectual ability scores among CMS patients. Emotional changes were observed in 40%-100% of participants across 23 studies.

Conclusions: CMS survivors face ongoing neurological, neuropsychological, and behavioral challenges, impacting their quality of life and highlighting the need for advancements in surgical techniques and rehabilitation interventions.

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来源期刊
Pediatric Blood & Cancer
Pediatric Blood & Cancer 医学-小儿科
CiteScore
4.90
自引率
9.40%
发文量
546
审稿时长
1.5 months
期刊介绍: Pediatric Blood & Cancer publishes the highest quality manuscripts describing basic and clinical investigations of blood disorders and malignant diseases of childhood including diagnosis, treatment, epidemiology, etiology, biology, and molecular and clinical genetics of these diseases as they affect children, adolescents, and young adults. Pediatric Blood & Cancer will also include studies on such treatment options as hematopoietic stem cell transplantation, immunology, and gene therapy.
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