新生儿缺血性中风可能与母体抗心磷脂免疫球蛋白G抗体经胎盘传递相关：1例报告。

IF 1.9 4区医学 Q3 RHEUMATOLOGY

Lupus Pub Date : 2025-09-29 DOI:10.1177/09612033251386089

Hiroshi Oiwa, Hideyuki Hawaka, Yuichiro Fujieda, Naoko Ueno, Seishi Sumi

{"title":"新生儿缺血性中风可能与母体抗心磷脂免疫球蛋白G抗体经胎盘传递相关：1例报告。","authors":"Hiroshi Oiwa, Hideyuki Hawaka, Yuichiro Fujieda, Naoko Ueno, Seishi Sumi","doi":"10.1177/09612033251386089","DOIUrl":null,"url":null,"abstract":"A baby girl, born to a 35-year-old mother, was admitted at 14.5 hours of life due to apnoea and seizures. Diffusion-weighted magnetic resonance imaging revealed multiple ischemic lesions. Laboratory screening for thrombophilia showed elevated levels of anti-cardiolipin IgG antibodies (aCL-IgG). The mother also tested positive for aCL-IgG, raising the possibility of transplacental antibody transfer. The neonate's aCL-IgG levels gradually declined and normalized by 4 months of age. Although causality cannot be established, this case suggests a potential association between transient maternal antiphospholipid antibodies and neonatal ischemic stroke.","PeriodicalId":18044,"journal":{"name":"Lupus","volume":" ","pages":"9612033251386089"},"PeriodicalIF":1.9000,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Neonatal ischemic stroke potentially associated with transplacental passage of maternal anti-cardiolipin immunoglobulin G antibodies: A case report.\",\"authors\":\"Hiroshi Oiwa, Hideyuki Hawaka, Yuichiro Fujieda, Naoko Ueno, Seishi Sumi\",\"doi\":\"10.1177/09612033251386089\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"A baby girl, born to a 35-year-old mother, was admitted at 14.5 hours of life due to apnoea and seizures. Diffusion-weighted magnetic resonance imaging revealed multiple ischemic lesions. Laboratory screening for thrombophilia showed elevated levels of anti-cardiolipin IgG antibodies (aCL-IgG). The mother also tested positive for aCL-IgG, raising the possibility of transplacental antibody transfer. The neonate's aCL-IgG levels gradually declined and normalized by 4 months of age. Although causality cannot be established, this case suggests a potential association between transient maternal antiphospholipid antibodies and neonatal ischemic stroke.\",\"PeriodicalId\":18044,\"journal\":{\"name\":\"Lupus\",\"volume\":\" \",\"pages\":\"9612033251386089\"},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2025-09-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Lupus\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1177/09612033251386089\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"RHEUMATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Lupus","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/09612033251386089","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"RHEUMATOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

一位35岁的母亲生下了一名女婴，由于呼吸暂停和癫痫发作，在出生14.5小时后入院。磁共振弥散加权成像显示多发缺血性病变。血栓病的实验室筛查显示抗心磷脂IgG抗体（aCL-IgG）水平升高。母亲的aCL-IgG检测也呈阳性，这增加了经胎盘抗体转移的可能性。新生儿的aCL-IgG水平在4月龄时逐渐下降并恢复正常。虽然不能确定因果关系，但本病例提示母体短暂性抗磷脂抗体与新生儿缺血性中风之间存在潜在关联。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Neonatal ischemic stroke potentially associated with transplacental passage of maternal anti-cardiolipin immunoglobulin G antibodies: A case report.

A baby girl, born to a 35-year-old mother, was admitted at 14.5 hours of life due to apnoea and seizures. Diffusion-weighted magnetic resonance imaging revealed multiple ischemic lesions. Laboratory screening for thrombophilia showed elevated levels of anti-cardiolipin IgG antibodies (aCL-IgG). The mother also tested positive for aCL-IgG, raising the possibility of transplacental antibody transfer. The neonate's aCL-IgG levels gradually declined and normalized by 4 months of age. Although causality cannot be established, this case suggests a potential association between transient maternal antiphospholipid antibodies and neonatal ischemic stroke.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Lupus 医学-风湿病学

CiteScore

4.20

自引率

11.50%

发文量

225

审稿时长

1 months

期刊介绍： The only fully peer reviewed international journal devoted exclusively to lupus (and related disease) research. Lupus includes the most promising new clinical and laboratory-based studies from leading specialists in all lupus-related disciplines. Invaluable reading, with extended coverage, lupus-related disciplines include: Rheumatology, Dermatology, Immunology, Obstetrics, Psychiatry and Cardiovascular Research…