{"title":"考虑温度依赖特性的脉冲激光照射下生物组织的热分析。","authors":"Yingze Wang, Zhaowei He, Sheng Zhang, Shuang Zeng","doi":"10.1016/j.jtherbio.2025.104279","DOIUrl":null,"url":null,"abstract":"<p><p>This study proposes an analytical approach to examine the thermal response of biological tissues with temperature-dependent properties subjected to pulsed laser irradiation. A bio-heat conduction model incorporating variable thermo-physical parameters was developed based on the dual-phase lag (DPL) heat conduction theory. Using the Laplace transform technique, an exact solution of the governing equation was derived in the transform domain, while numerical solutions in the time domain were obtained through the Stehfest inversion algorithm. The temperature distributions in typical biological tissues under pulsed laser irradiation were systematically computed, and the influences of temperature-dependent thermal parameters, blood perfusion rate, and metabolic heat generation were quantitatively evaluated under distinct heating mechanisms governed by phase lag times. The results reveal significant variations in thermal response due to temperature dependence, offering valuable insights for optimizing thermal therapy protocols.</p>","PeriodicalId":17428,"journal":{"name":"Journal of thermal biology","volume":"133 ","pages":"104279"},"PeriodicalIF":2.9000,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Thermal analysis of biological tissue under pulsed laser irradiation accounting for temperature-dependent properties.\",\"authors\":\"Yingze Wang, Zhaowei He, Sheng Zhang, Shuang Zeng\",\"doi\":\"10.1016/j.jtherbio.2025.104279\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>This study proposes an analytical approach to examine the thermal response of biological tissues with temperature-dependent properties subjected to pulsed laser irradiation. A bio-heat conduction model incorporating variable thermo-physical parameters was developed based on the dual-phase lag (DPL) heat conduction theory. Using the Laplace transform technique, an exact solution of the governing equation was derived in the transform domain, while numerical solutions in the time domain were obtained through the Stehfest inversion algorithm. The temperature distributions in typical biological tissues under pulsed laser irradiation were systematically computed, and the influences of temperature-dependent thermal parameters, blood perfusion rate, and metabolic heat generation were quantitatively evaluated under distinct heating mechanisms governed by phase lag times. The results reveal significant variations in thermal response due to temperature dependence, offering valuable insights for optimizing thermal therapy protocols.</p>\",\"PeriodicalId\":17428,\"journal\":{\"name\":\"Journal of thermal biology\",\"volume\":\"133 \",\"pages\":\"104279\"},\"PeriodicalIF\":2.9000,\"publicationDate\":\"2025-09-24\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of thermal biology\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.1016/j.jtherbio.2025.104279\",\"RegionNum\":2,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of thermal biology","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1016/j.jtherbio.2025.104279","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOLOGY","Score":null,"Total":0}
Thermal analysis of biological tissue under pulsed laser irradiation accounting for temperature-dependent properties.
This study proposes an analytical approach to examine the thermal response of biological tissues with temperature-dependent properties subjected to pulsed laser irradiation. A bio-heat conduction model incorporating variable thermo-physical parameters was developed based on the dual-phase lag (DPL) heat conduction theory. Using the Laplace transform technique, an exact solution of the governing equation was derived in the transform domain, while numerical solutions in the time domain were obtained through the Stehfest inversion algorithm. The temperature distributions in typical biological tissues under pulsed laser irradiation were systematically computed, and the influences of temperature-dependent thermal parameters, blood perfusion rate, and metabolic heat generation were quantitatively evaluated under distinct heating mechanisms governed by phase lag times. The results reveal significant variations in thermal response due to temperature dependence, offering valuable insights for optimizing thermal therapy protocols.
期刊介绍:
The Journal of Thermal Biology publishes articles that advance our knowledge on the ways and mechanisms through which temperature affects man and animals. This includes studies of their responses to these effects and on the ecological consequences. Directly relevant to this theme are:
• The mechanisms of thermal limitation, heat and cold injury, and the resistance of organisms to extremes of temperature
• The mechanisms involved in acclimation, acclimatization and evolutionary adaptation to temperature
• Mechanisms underlying the patterns of hibernation, torpor, dormancy, aestivation and diapause
• Effects of temperature on reproduction and development, growth, ageing and life-span
• Studies on modelling heat transfer between organisms and their environment
• The contributions of temperature to effects of climate change on animal species and man
• Studies of conservation biology and physiology related to temperature
• Behavioural and physiological regulation of body temperature including its pathophysiology and fever
• Medical applications of hypo- and hyperthermia
Article types:
• Original articles
• Review articles