空蝶鞍综合征:对垂体功能的长期影响。

Q3 Medicine
Latifa Yagoubi, Amal Ourdi, Nisrine Bouichrat, Siham Rouf, Hanane Latrech
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引用次数: 0

摘要

空蝶鞍综合征(ESS)的特点是脑脊液突出进入垂体窝,经常引起垂体功能障碍。虽然ESS通常无症状,但它可导致进行性激素缺乏。缺乏对ESS患者垂体功能的长期研究。本研究旨在评估ESS患者的垂体功能,监测激素缺乏的进展,并探讨性别、年龄和体重指数(BMI)的影响。这是一项描述性和分析性研究,涉及2014年至2024年间在我校医院诊断为ESS并接受治疗的41例患者。所有患者均接受MRI和内分泌测试,包括皮质醇、促甲状腺素、游离甲状腺素、催乳素、生长激素、性腺激素和睾酮。中位随访时间为5年,6个月至10年不等。数据收集和分析使用SPSS 21版。在诊断时,82.9%的患者至少有一种垂体激素缺乏,主要是肾上腺激素、性腺激素和生长激素轴。女性发生性腺功能障碍的可能性(34.1%)高于男性(21.9%)。年龄与肾上腺/性腺功能不全呈正相关。此外,研究还发现高BMI与性腺功能不全之间存在显著关联,这突出了肥胖在加剧垂体功能障碍中的作用。ESS通常与垂体功能障碍有关,特别是肾上腺轴和性腺轴。性别、年龄和体重指数影响激素缺乏的发生和进展,强调对这些患者进行定期内分泌评估和长期随访的必要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Empty Sella Syndrome: long-term impact on pituitary function.

Empty Sella Syndrome (ESS) is characterized by a herniation of cerebrospinal fluid into the pituitary fossa, frequently causing pituitary dysfunction. Although ESS is generally asymptomatic, it can lead to progressive hormonal deficiencies. Long-term studies of pituitary function in patients with ESS are lacking. This study aimed to evaluate pituitary function in ESS patients, monitor the progression of hormone deficiencies, and explore the impact of gender, age, and body mass index (BMI). This is a descriptive and analytical study involving 41 patients diagnosed with ESS and treated at our university hospital between 2014 and 2024. All patients underwent MRI and endocrine testing for cortisol, thyrotropin, free thyroxine, prolactin, growth hormone, gonadal hormones, and testosterone. The median duration of follow-up was 5 years, with a range of 6 months to 10 years. Data was collected and analyzed using SPSS version 21. At diagnosis, 82.9% of patients had at least one pituitary hormone deficiency, primarily in the adrenal, gonadal, and growth hormone axes. Women were more likely to develop gonadal dysfunction (34.1%) than men (21.9%). A positive correlation between age and adrenal/gonadal insufficiency was observed. Additionally, a significant association was found between higher BMI and gonadal insufficiency, highlighting the role of obesity in exacerbating pituitary dysfunction. ESS is commonly linked to pituitary dysfunction, particularly in the adrenal and gonadal axes. Gender, age, and BMI influence the development and progression of hormonal deficiencies, underscoring the need for regular endocrine evaluation and long-term follow-up in these patients.

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来源期刊
Journal of Medicine and Life
Journal of Medicine and Life Medicine-Medicine (all)
CiteScore
1.90
自引率
0.00%
发文量
202
期刊介绍: The Journal of Medicine and Life publishes peer-reviewed articles from various fields of medicine and life sciences, including original research, systematic reviews, special reports, case presentations, major medical breakthroughs and letters to the editor. The Journal focuses on current matters that lie at the intersection of biomedical science and clinical practice and strives to present this information to inform health care delivery and improve patient outcomes. Papers addressing topics such as neuroprotection, neurorehabilitation, neuroplasticity, and neuroregeneration are particularly encouraged, as part of the Journal''s continuous interest in neuroscience research. The Editorial Board of the Journal of Medicine and Life is open to consider manuscripts from all levels of research and areas of biological sciences, including fundamental, experimental or clinical research and matters of public health. As part of our pledge to promote an educational and community-building environment, our issues feature sections designated to informing our readers regarding exciting international congresses, teaching courses and relevant institutional-level events.
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