Comparison of Efficacy in the Treatment of Otomycosis using 10% Povidone-Iodine and Clotrimazole Solution: Randomized, Double-Blind Control Trial.

Introduction: The main treatment of otomycosis has required the use of topical antifungal drops and/or acidifying agents. However, because of the availability issues of antifungal drops in developing countries, treatment with acidifying agents alone is necessary.

Objective: The objective of this study was to compare the efficacy in the treatment of otomycosis using a 10% povidone-iodine and clotrimazole solution.

Methods: Patients with otomycosis were assigned to 10% povidone-iodine group and Clotrimazole group. The patients were evaluated on the response of each group at 1, 2,4 and 8 weeks.

Results: 93 patients were assigned to the 10% povidone-iodine group and 95 patients to the Clotrimazole group. the response to treatment between groups. In the second week after treatment, 37.64% of the 10% povidone-iodine group and 40% of the Clotrimazole group had a good response to treatment (p = 0.551). In the fourth week after treatment, 52.69% of the 10% povidone-iodine group and 55.79% of the Clotrimazole group had a good response to treatment (p = 0.644). In the eighth week after treatment, 58.06% of the 10% povidone-iodine group and 64.21% of the Clotrimazole group had a good response to treatment (p = 0.642) In the 12th week after treatment, 76.34% of the 10% povidone-iodine group and 85.26% of the Clotrimazole group had a good response to treatment (p = 0.248).

Conclusions: There were no significant differences in the response to between 10% povidone-iodine and Clotrimazole groups in the second, fourth, eighth and twelfths after treatment.