脊髓损伤后脊髓静息状态功能连通性与电生理的关系

IF 3.3 2区 医学 Q1 NEUROIMAGING
Pai-Feng Yang, Jamie L Reed, Anirban Sengupta, Arabinda Mishra, Feng Wang, John C Gore, Li Min Chen
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引用次数: 0

摘要

我们之前报道了颈椎C4水平单侧背柱病变(DCL)主要降低病变下方节段功能性磁共振成像(fMRI)测量的角间静息状态功能连通性(rsFC)。本研究比较了功能磁共振成像中rsFC的变化与局部场电位(LFP)相干性在损伤后较长时间内的变化。在健康猴子的双侧以及病变后3个月和6个月获得高分辨率fMRI和LFP数据。损伤后3个月,触觉刺激诱发的脊髓背角LFP功率明显弱于正常脊髓和非损伤侧。背侧到中间区(D-IGM)和背侧到腹侧(D-V)对的LFP相干性在病变侧增加,而非病变侧D-IGM的LFP相干性降低。6个月时,损伤侧刺激诱发的LFP功率仍然很低。与健康脊髓相比,病变侧和非病变侧背侧到背侧(D-D)、腹侧到腹侧(V-V)和D-V对之间的LFP一致性显著降低。病变侧的低频(δ、θ和α) D-IGM相干性和非病变侧的高频(β和γ)相干性也明显减弱。在特定的角间对和时间点上,LFP一致性和rsFC测量的变化呈弱相关。C7椎间角间相关性的测量显示DCL后椎内连通性的距离依赖性改变。大多数动物死后组织学证实完全DCL(7/9)。从组织学上评估,上行感觉传入的破坏程度似乎与损伤后时间点LFP功率降低或rsFC变化的程度无关。总之,我们观察到脊髓内回路中fMRI相关性和LFP一致性的时间和空间异质性变化。fMRI rsFC和LFP一致性并不总是一致的,差异取决于特定的灰质角和中间区对。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Relationships Between Intra-Spinal Resting-State Functional Connectivity and Electrophysiology Following Spinal Cord Injury.

We previously reported that a unilateral dorsal column lesion (DCL) at the cervical C4 level primarily reduces inter-horn resting-state functional connectivity (rsFC) measured by functional Magnetic Resonance Imaging (fMRI) in segments below the lesion. This study compares changes in rsFC from fMRI with changes in local field potential (LFP) coherence over an extended post-injury period. High-resolution fMRI and LFP data were acquired bilaterally in healthy monkeys and at 3- and 6-months post-lesion. At 3 months post-injury, tactile-stimulus-evoked LFP power in the dorsal horn was significantly weaker than in the healthy cord and non-lesion side. LFP coherences increased on the lesion side for the dorsal-to-intermediate zone (D-IGM) and dorsal-to-ventral (D-V) pairs but decreased for the non-lesion side D-IGM. By 6 months, stimulus-evoked LFP power on the lesion side remained low. LFP coherences between dorsal-to-dorsal (D-D), ventral-to-ventral (V-V), and D-V pairs on both the lesion and non-lesion sides were significantly reduced relative to the healthy cord. Low-frequency (delta, theta, and alpha) D-IGM coherences on the lesion side, and high-frequency (beta and gamma) coherences on the non-lesion side, were also significantly weakened. Across specific inter-horn pairs and time points, changes in LFP coherences and rsFC measures were weakly correlated. Measurements of inter-horn correlations two segments caudal to the lesion level at C7 revealed distance-dependent intraspinal connectivity changes following DCL. Post-mortem histology confirmed a complete DCL in most animals (7/9). The extent of the disruption of ascending sensory afferents, as assessed histologically, did not appear to correlate with the degree of LFP power reduction or rsFC changes at post-injury time points. In summary, we observed temporally and spatially heterogeneous changes of fMRI correlations and LFP coherences within intraspinal circuits. fMRI rsFC and LFP coherences were not always concordant, with discrepancies depending on specific gray-matter horns and intermediate-zone pairs.

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来源期刊
Human Brain Mapping
Human Brain Mapping 医学-核医学
CiteScore
8.30
自引率
6.20%
发文量
401
审稿时长
3-6 weeks
期刊介绍: Human Brain Mapping publishes peer-reviewed basic, clinical, technical, and theoretical research in the interdisciplinary and rapidly expanding field of human brain mapping. The journal features research derived from non-invasive brain imaging modalities used to explore the spatial and temporal organization of the neural systems supporting human behavior. Imaging modalities of interest include positron emission tomography, event-related potentials, electro-and magnetoencephalography, magnetic resonance imaging, and single-photon emission tomography. Brain mapping research in both normal and clinical populations is encouraged. Article formats include Research Articles, Review Articles, Clinical Case Studies, and Technique, as well as Technological Developments, Theoretical Articles, and Synthetic Reviews. Technical advances, such as novel brain imaging methods, analyses for detecting or localizing neural activity, synergistic uses of multiple imaging modalities, and strategies for the design of behavioral paradigms and neural-systems modeling are of particular interest. The journal endorses the propagation of methodological standards and encourages database development in the field of human brain mapping.
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