{"title":"亚洲人骨质疏松自我评估工具与台湾绝经后妇女跟骨定量超声鉴别原发性骨质疏松。","authors":"Dung-Huan Liu, Chih-Sheng Lin, Pei-Ching Wu","doi":"10.3389/fendo.2025.1639176","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>This study compares Osteoporosis Self-Assessment Tool for Asians (OSTA) and Calcaneal Quantitative Ultrasound (QUS) to detect primary osteoporosis among Taiwanese postmenopausal women and assess the consistency between both methods.</p><p><strong>Methods: </strong>8,883 postmenopausal women were selected from Taiwan Biobank. Osteoporosis was diagnosed using Dual-energy X-ray absorptiometry (DXA) with T-score≦-2.5 under WHO definition. QUS and OSTA were employed to assess osteoporosis risk, with statistical analyses including receiver operating characteristic curve (ROC) analysis, Delong's test, and McNemar's test to compare the performance of both tools. Youden's J statistic identifies the optimal cut-off values of OSTA and QUS SI. Cohen's kappa coefficient (k) and Spearman's rank correlation coefficient (r<sub>s</sub>) assessed the correlation between OSTA, QUS, and DXA.</p><p><strong>Results: </strong>QUS outperformed OSTA with superior AUC in primary osteoporosis screening of Taiwanese postmenopausal women under WHO osteoporosis definition (AUC of QUS and OSTA are 0.737 and 0.703; p<0.05). They could independently screen and track the women at primary osteoporosis risk but not replace DXA for osteoporosis diagnosis, because they had a fair agreement of k (0.293~0.342) and a moderate correlation of r<sub>s</sub> (0.424~0.481) with DXA. They couldn't screen and track the women at primary osteoporosis risk interchangeably because their agreement is minimal (k=0.197; r<sub>s</sub>=0.271; p<0.05).</p><p><strong>Conclusions: </strong>QUS and OSTA are radiation-free, portable, less expensive and time-consuming, and effective screening tools for primary osteoporosis in Taiwanese postmenopausal women, with QUS being the superior method under WHO osteoporosis definition. After further age-stratified analysis for detecting primary osteoporosis in Taiwanese postmenopausal women, QUS outperformed OSTA in those aged 45 - 65, while OSTA outperformed QUS in those aged 66 - 80.</p>","PeriodicalId":12447,"journal":{"name":"Frontiers in Endocrinology","volume":"16 ","pages":"1639176"},"PeriodicalIF":4.6000,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12464885/pdf/","citationCount":"0","resultStr":"{\"title\":\"Osteoporosis self-assessment tool for Asians and calcaneal quantitative ultrasound for identifying primary osteoporosis in Taiwanese postmenopausal women.\",\"authors\":\"Dung-Huan Liu, Chih-Sheng Lin, Pei-Ching Wu\",\"doi\":\"10.3389/fendo.2025.1639176\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objectives: </strong>This study compares Osteoporosis Self-Assessment Tool for Asians (OSTA) and Calcaneal Quantitative Ultrasound (QUS) to detect primary osteoporosis among Taiwanese postmenopausal women and assess the consistency between both methods.</p><p><strong>Methods: </strong>8,883 postmenopausal women were selected from Taiwan Biobank. Osteoporosis was diagnosed using Dual-energy X-ray absorptiometry (DXA) with T-score≦-2.5 under WHO definition. QUS and OSTA were employed to assess osteoporosis risk, with statistical analyses including receiver operating characteristic curve (ROC) analysis, Delong's test, and McNemar's test to compare the performance of both tools. Youden's J statistic identifies the optimal cut-off values of OSTA and QUS SI. Cohen's kappa coefficient (k) and Spearman's rank correlation coefficient (r<sub>s</sub>) assessed the correlation between OSTA, QUS, and DXA.</p><p><strong>Results: </strong>QUS outperformed OSTA with superior AUC in primary osteoporosis screening of Taiwanese postmenopausal women under WHO osteoporosis definition (AUC of QUS and OSTA are 0.737 and 0.703; p<0.05). They could independently screen and track the women at primary osteoporosis risk but not replace DXA for osteoporosis diagnosis, because they had a fair agreement of k (0.293~0.342) and a moderate correlation of r<sub>s</sub> (0.424~0.481) with DXA. They couldn't screen and track the women at primary osteoporosis risk interchangeably because their agreement is minimal (k=0.197; r<sub>s</sub>=0.271; p<0.05).</p><p><strong>Conclusions: </strong>QUS and OSTA are radiation-free, portable, less expensive and time-consuming, and effective screening tools for primary osteoporosis in Taiwanese postmenopausal women, with QUS being the superior method under WHO osteoporosis definition. After further age-stratified analysis for detecting primary osteoporosis in Taiwanese postmenopausal women, QUS outperformed OSTA in those aged 45 - 65, while OSTA outperformed QUS in those aged 66 - 80.</p>\",\"PeriodicalId\":12447,\"journal\":{\"name\":\"Frontiers in Endocrinology\",\"volume\":\"16 \",\"pages\":\"1639176\"},\"PeriodicalIF\":4.6000,\"publicationDate\":\"2025-09-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12464885/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Frontiers in Endocrinology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.3389/fendo.2025.1639176\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"ENDOCRINOLOGY & METABOLISM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Endocrinology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3389/fendo.2025.1639176","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
Osteoporosis self-assessment tool for Asians and calcaneal quantitative ultrasound for identifying primary osteoporosis in Taiwanese postmenopausal women.
Objectives: This study compares Osteoporosis Self-Assessment Tool for Asians (OSTA) and Calcaneal Quantitative Ultrasound (QUS) to detect primary osteoporosis among Taiwanese postmenopausal women and assess the consistency between both methods.
Methods: 8,883 postmenopausal women were selected from Taiwan Biobank. Osteoporosis was diagnosed using Dual-energy X-ray absorptiometry (DXA) with T-score≦-2.5 under WHO definition. QUS and OSTA were employed to assess osteoporosis risk, with statistical analyses including receiver operating characteristic curve (ROC) analysis, Delong's test, and McNemar's test to compare the performance of both tools. Youden's J statistic identifies the optimal cut-off values of OSTA and QUS SI. Cohen's kappa coefficient (k) and Spearman's rank correlation coefficient (rs) assessed the correlation between OSTA, QUS, and DXA.
Results: QUS outperformed OSTA with superior AUC in primary osteoporosis screening of Taiwanese postmenopausal women under WHO osteoporosis definition (AUC of QUS and OSTA are 0.737 and 0.703; p<0.05). They could independently screen and track the women at primary osteoporosis risk but not replace DXA for osteoporosis diagnosis, because they had a fair agreement of k (0.293~0.342) and a moderate correlation of rs (0.424~0.481) with DXA. They couldn't screen and track the women at primary osteoporosis risk interchangeably because their agreement is minimal (k=0.197; rs=0.271; p<0.05).
Conclusions: QUS and OSTA are radiation-free, portable, less expensive and time-consuming, and effective screening tools for primary osteoporosis in Taiwanese postmenopausal women, with QUS being the superior method under WHO osteoporosis definition. After further age-stratified analysis for detecting primary osteoporosis in Taiwanese postmenopausal women, QUS outperformed OSTA in those aged 45 - 65, while OSTA outperformed QUS in those aged 66 - 80.
期刊介绍：
Frontiers in Endocrinology is a field journal of the "Frontiers in" journal series.
In today’s world, endocrinology is becoming increasingly important as it underlies many of the challenges societies face - from obesity and diabetes to reproduction, population control and aging. Endocrinology covers a broad field from basic molecular and cellular communication through to clinical care and some of the most crucial public health issues. The journal, thus, welcomes outstanding contributions in any domain of endocrinology.
Frontiers in Endocrinology publishes articles on the most outstanding discoveries across a wide research spectrum of Endocrinology. The mission of Frontiers in Endocrinology is to bring all relevant Endocrinology areas together on a single platform.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
