{"title":"口腔癌中唾液免疫复合物抗原的鉴定与表征。","authors":"Maria Sei, Sayo Kanda, Nozomi Aibara, Rean Hashimura, Junya Hashizume, Yuki Jimbayashi Kutsuna, Tomofumi Naruse, Keisuke Omori, Hironori Sakai, Shin-Ichi Yamada, Takumi Hasegawa, Daisuke Takeda, Nobuhiro Yamakawa, Tadaaki Kirita, Tomoaki Kurosaki, Hirotaka Miyamoto, Kayoko Sato, Yukinobu Kodama, Mihoko N Nakashima, Mikiro Nakashima, Souichi Yanamoto, Kaname Ohyama","doi":"10.1007/s00784-025-06549-1","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>This study aims to identify antigens incorporated into immune complexes that are associated with oral cancer pathogenesis and to determine their potential clinical applications.</p><p><strong>Materials and methods: </strong>In this study, immune complexome analysis was performed on saliva samples from 66 patients with oral cancer and 40 controls. Immune complexome analysis is an original method for the comprehensive identification of immune complex antigens in body fluids by liquid chromatography-mass spectrometry.</p><p><strong>Results: </strong>We identified 24 IC-antigens that were significantly elevated in early-stage oral cancer compared with the controls, suggesting their potential as indicators for oral cancer. Four IC-antigens (ALOX5, B3GALT6, LAMA4, POLA1) were expressed at significantly higher levels in advanced-stage disease, indicating their involvement in cancer progression. Survival analysis revealed that high levels of POLA1 were associated with lower survival rates. Most of these proteins were reported to be involved in cancer progression and cell proliferation.</p><p><strong>Conclusion: </strong>These findings support the formation of disease-characteristic immune complexes in oral cancer and highlight the potential of immune complexome analysis in saliva for understanding oral cancer pathogenesis and therapeutic targets.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 10","pages":"482"},"PeriodicalIF":3.1000,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Identification and characterization of salivary immune complex antigens in oral cancer.\",\"authors\":\"Maria Sei, Sayo Kanda, Nozomi Aibara, Rean Hashimura, Junya Hashizume, Yuki Jimbayashi Kutsuna, Tomofumi Naruse, Keisuke Omori, Hironori Sakai, Shin-Ichi Yamada, Takumi Hasegawa, Daisuke Takeda, Nobuhiro Yamakawa, Tadaaki Kirita, Tomoaki Kurosaki, Hirotaka Miyamoto, Kayoko Sato, Yukinobu Kodama, Mihoko N Nakashima, Mikiro Nakashima, Souichi Yanamoto, Kaname Ohyama\",\"doi\":\"10.1007/s00784-025-06549-1\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objectives: </strong>This study aims to identify antigens incorporated into immune complexes that are associated with oral cancer pathogenesis and to determine their potential clinical applications.</p><p><strong>Materials and methods: </strong>In this study, immune complexome analysis was performed on saliva samples from 66 patients with oral cancer and 40 controls. Immune complexome analysis is an original method for the comprehensive identification of immune complex antigens in body fluids by liquid chromatography-mass spectrometry.</p><p><strong>Results: </strong>We identified 24 IC-antigens that were significantly elevated in early-stage oral cancer compared with the controls, suggesting their potential as indicators for oral cancer. Four IC-antigens (ALOX5, B3GALT6, LAMA4, POLA1) were expressed at significantly higher levels in advanced-stage disease, indicating their involvement in cancer progression. Survival analysis revealed that high levels of POLA1 were associated with lower survival rates. Most of these proteins were reported to be involved in cancer progression and cell proliferation.</p><p><strong>Conclusion: </strong>These findings support the formation of disease-characteristic immune complexes in oral cancer and highlight the potential of immune complexome analysis in saliva for understanding oral cancer pathogenesis and therapeutic targets.</p>\",\"PeriodicalId\":10461,\"journal\":{\"name\":\"Clinical Oral Investigations\",\"volume\":\"29 10\",\"pages\":\"482\"},\"PeriodicalIF\":3.1000,\"publicationDate\":\"2025-09-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical Oral Investigations\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s00784-025-06549-1\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"DENTISTRY, ORAL SURGERY & MEDICINE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Oral Investigations","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00784-025-06549-1","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}
Identification and characterization of salivary immune complex antigens in oral cancer.
Objectives: This study aims to identify antigens incorporated into immune complexes that are associated with oral cancer pathogenesis and to determine their potential clinical applications.
Materials and methods: In this study, immune complexome analysis was performed on saliva samples from 66 patients with oral cancer and 40 controls. Immune complexome analysis is an original method for the comprehensive identification of immune complex antigens in body fluids by liquid chromatography-mass spectrometry.
Results: We identified 24 IC-antigens that were significantly elevated in early-stage oral cancer compared with the controls, suggesting their potential as indicators for oral cancer. Four IC-antigens (ALOX5, B3GALT6, LAMA4, POLA1) were expressed at significantly higher levels in advanced-stage disease, indicating their involvement in cancer progression. Survival analysis revealed that high levels of POLA1 were associated with lower survival rates. Most of these proteins were reported to be involved in cancer progression and cell proliferation.
Conclusion: These findings support the formation of disease-characteristic immune complexes in oral cancer and highlight the potential of immune complexome analysis in saliva for understanding oral cancer pathogenesis and therapeutic targets.
期刊介绍：
The journal Clinical Oral Investigations is a multidisciplinary, international forum for publication of research from all fields of oral medicine. The journal publishes original scientific articles and invited reviews which provide up-to-date results of basic and clinical studies in oral and maxillofacial science and medicine. The aim is to clarify the relevance of new results to modern practice, for an international readership. Coverage includes maxillofacial and oral surgery, prosthetics and restorative dentistry, operative dentistry, endodontics, periodontology, orthodontics, dental materials science, clinical trials, epidemiology, pedodontics, oral implant, preventive dentistiry, oral pathology, oral basic sciences and more.
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