{"title":"当归属多糖的结构分析及其生物活性综述。","authors":"Xin-Ai Li, Mingyang Cao, Zhi-Min Jian, Fang-Yu Li, Yong-Hui Rui, Ai-En Tao","doi":"10.1016/j.carres.2025.109689","DOIUrl":null,"url":null,"abstract":"<p><p>Angelica sinensis (Oliv.) Diels, a perennial herbaceous plant belonging to the Umbelliferae family, is a traditional Chinese medicine commonly used for nourishing blood. The primary bioactive components of Angelica sinensis are polysaccharides, which exhibit various biological functions, including anti-inflammatory, anti-tumor, antioxidant, liver-protective, immune-regulating, and hematopoietic activities. Although numerous studies exist on Angelica polysaccharides, significant knowledge gaps remain regarding genus Angelica polysaccharides (GAPs) isolation, biological activity, structure-activity relationships (SARs), and diverse application potentials. This somewhat hinders the application of GAPs in clinical and market industrialization processes. This article aims to explore and summarize the research progress of GAPs in extraction, separation, purification, structural characteristics, biological activity, and structure-activity relationships, and to examine and emphasize potential application areas and future research directions. This review helps to fill the knowledge gap between theoretical insights and practical applications, guiding future research and industrial applications of GAPs.</p>","PeriodicalId":9415,"journal":{"name":"Carbohydrate Research","volume":"558 ","pages":"109689"},"PeriodicalIF":2.5000,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Structural analysis of polysaccharides of the genus Angelica and an overview of their biological activity.\",\"authors\":\"Xin-Ai Li, Mingyang Cao, Zhi-Min Jian, Fang-Yu Li, Yong-Hui Rui, Ai-En Tao\",\"doi\":\"10.1016/j.carres.2025.109689\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Angelica sinensis (Oliv.) Diels, a perennial herbaceous plant belonging to the Umbelliferae family, is a traditional Chinese medicine commonly used for nourishing blood. The primary bioactive components of Angelica sinensis are polysaccharides, which exhibit various biological functions, including anti-inflammatory, anti-tumor, antioxidant, liver-protective, immune-regulating, and hematopoietic activities. Although numerous studies exist on Angelica polysaccharides, significant knowledge gaps remain regarding genus Angelica polysaccharides (GAPs) isolation, biological activity, structure-activity relationships (SARs), and diverse application potentials. This somewhat hinders the application of GAPs in clinical and market industrialization processes. This article aims to explore and summarize the research progress of GAPs in extraction, separation, purification, structural characteristics, biological activity, and structure-activity relationships, and to examine and emphasize potential application areas and future research directions. This review helps to fill the knowledge gap between theoretical insights and practical applications, guiding future research and industrial applications of GAPs.</p>\",\"PeriodicalId\":9415,\"journal\":{\"name\":\"Carbohydrate Research\",\"volume\":\"558 \",\"pages\":\"109689\"},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2025-09-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Carbohydrate Research\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://doi.org/10.1016/j.carres.2025.109689\",\"RegionNum\":3,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Carbohydrate Research","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1016/j.carres.2025.109689","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
Structural analysis of polysaccharides of the genus Angelica and an overview of their biological activity.
Angelica sinensis (Oliv.) Diels, a perennial herbaceous plant belonging to the Umbelliferae family, is a traditional Chinese medicine commonly used for nourishing blood. The primary bioactive components of Angelica sinensis are polysaccharides, which exhibit various biological functions, including anti-inflammatory, anti-tumor, antioxidant, liver-protective, immune-regulating, and hematopoietic activities. Although numerous studies exist on Angelica polysaccharides, significant knowledge gaps remain regarding genus Angelica polysaccharides (GAPs) isolation, biological activity, structure-activity relationships (SARs), and diverse application potentials. This somewhat hinders the application of GAPs in clinical and market industrialization processes. This article aims to explore and summarize the research progress of GAPs in extraction, separation, purification, structural characteristics, biological activity, and structure-activity relationships, and to examine and emphasize potential application areas and future research directions. This review helps to fill the knowledge gap between theoretical insights and practical applications, guiding future research and industrial applications of GAPs.
期刊介绍：
Carbohydrate Research publishes reports of original research in the following areas of carbohydrate science: action of enzymes, analytical chemistry, biochemistry (biosynthesis, degradation, structural and functional biochemistry, conformation, molecular recognition, enzyme mechanisms, carbohydrate-processing enzymes, including glycosidases and glycosyltransferases), chemical synthesis, isolation of natural products, physicochemical studies, reactions and their mechanisms, the study of structures and stereochemistry, and technological aspects.
Papers on polysaccharides should have a "molecular" component; that is a paper on new or modified polysaccharides should include structural information and characterization in addition to the usual studies of rheological properties and the like. A paper on a new, naturally occurring polysaccharide should include structural information, defining monosaccharide components and linkage sequence.
Papers devoted wholly or partly to X-ray crystallographic studies, or to computational aspects (molecular mechanics or molecular orbital calculations, simulations via molecular dynamics), will be considered if they meet certain criteria. For computational papers the requirements are that the methods used be specified in sufficient detail to permit replication of the results, and that the conclusions be shown to have relevance to experimental observations - the authors'' own data or data from the literature. Specific directions for the presentation of X-ray data are given below under Results and "discussion".
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