评估雌性大鼠睡眠-觉醒状态相关的心率变异性动态变化:研究行为失调的自主系统建模方法。

IF 2.4 Q4 NEUROSCIENCES
Arshajyothirmayi Va, Narayanan Namboodiri, Kamalesh K Gulia
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引用次数: 0

摘要

背景:急性心率变异性(HRV)用于评估人类受试者清醒静息状态下的功能性自主神经谱。通过HRV评估不同睡眠阶段交感神经-迷走神经平衡的24小时变化对了解各种生活方式疾病的基础是有价值的,然而,这样的研究并不常见。目的:本研究以心率变异为工具,模拟自由活动雌性Wistar大鼠在明暗期睡眠-觉醒相关的心脏自主神经变化。方法:通过脑电图(EEG)和肌电图(EMG)评估睡眠状态(非快速眼动(NREM)和快速眼动(REM)睡眠),同时获取心电信号进行HRV分析。为了了解昼夜动力学,我们分析了无噪声的不同睡眠-觉醒状态段和过渡状态段的HRV。结果:在时域参数上,非快速眼动睡眠的RR间隔较清醒期和快速眼动期更长。在频域,与其他状态相比,非快速眼动睡眠期间低频功率的降低和高频功率的增加是明显的。与亮期相比,暗期清醒时的RR间隔明显缩短。在所有三种状态下,RR间隔在光照期早期(6-10 am)最长。结论:NREM睡眠期间的副交感神经优势与人类的单相模式相似,而大鼠在大多数过渡状态(本质上是多相的)时交感神经张力较高,表明存在交感神经-迷走神经平衡失调与睡眠片段化的风险。此外,光前期的副交感神经活动最高,暗期的交感神经驱动最高,可能是夜间生存的一种适应机制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Assessment of Sleep-wake State-associated Dynamic Changes in Heart Rate Variability in Female Rat: Autonomic System Modelling Approaches for Studying Behavioural Dysregulation.

Background: Acute heart rate variability (HRV) is used for assessment of functional autonomic profile in awake resting state in humans subjects. Evaluation of 24-h variations in the sympatho-vagal balance across sleep stages through HRV are valuable to understand the basis of various lifestyles diseases, however, such studies are uncommon.

Purpose: The present study modelled the sleep-wake associated cardiac autonomic changes in freely moving female Wistar rats across light and dark phase using HRV as a tool.

Methods: Sleep states (non-rapid eye movement [NREM] and rapid eye movement [REM] sleep) were estimated through electroencephalogram (EEG) and electromyogram (EMG), while the ECG signal was acquired simultaneously for HRV analysis. To understand circadian dynamics, HRV was analysed for noise-free distinct and transitional state segments of sleep-wakefulness.

Results: In time domain parameters, RR intervals during NREM sleep were longer in comparison to wake and REM sleep. In the frequency domain, reductions in LF and an increase in HF power during NREM sleep were evident compared to other states. RR interval during wakefulness in the dark phase was significantly decreased compared to the light phase. The RR interval was the longest during the early phase of the light period (6-10 am) in all three states.

Conclusion: Parasympathetic predominance during NREM sleep was similar to a human having a monophasic pattern, while a higher sympathetic tone during the majority of transitional states in rats, which are polyphasic in nature, indicated risk of dysregulated sympatho-vagal balance with fragmented sleep. Further, the highest parasympathetic activity during the early light phase and the highest sympathetic drive during the dark phase may serve as an adaptive mechanism for survival in nocturnal life.

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来源期刊
Annals of Neurosciences
Annals of Neurosciences NEUROSCIENCES-
CiteScore
2.40
自引率
0.00%
发文量
39
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