预防- ad队列:加速阿尔茨海默病在加拿大和其他地区的研究和治疗。

IF 11.1 1区 医学 Q1 CLINICAL NEUROLOGY
Sylvia Villeneuve, Judes Poirier, John C S Breitner, Jennifer Tremblay-Mercier, Jordana Remz, Jean-Michel Raoult, Yara Yakoub, Jonathan Gallego-Rudolf, Ting Qiu, Alfonso Fajardo Valdez, Bery Mohammediyan, Mohammadali Javanray, Amelie Metz, Safa Sanami, Valentin Ourry, Alfie Wearn, Alexandre Pastor-Bernier, Manon Edde, Julie Gonneaud, Cherie Strikwerda-Brown, Christine L Tardif, Claudine J Gauthier, Maxime Descoteaux, Mahsa Dadar, Étienne Vachon-Presseau, Andrée-Ann Baril, Simon Ducharme, Maxime Montembeault, Maiya R Geddes, Jean-Paul Soucy, Natasha Rajah, Robert Laforce, Christian Bocti, Christos Davatzikos, Lune Bellec, Pedro Rosa-Neto, Sylvain Baillet, Alan C Evans, D Louis Collins, M Mallar Chakravarty, Kaj Blennow, Henrik Zetterberg, R Nathan Spreng, Alexa Pichet Binette
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引用次数: 0

摘要

阿尔茨海默病的实验性或新型治疗方法的症状前评估(prevention -AD)是一项由研究者驱动的研究,于2011年创建,招募了具有散发性阿尔茨海默病家族史的认知正常的老年人。参与者被深度表型化,现在每年随访超过12年(中位随访8年,标准差3.1)。截至2017年,已经收集了348名同意与神经科学界开放共享的参与者的多模态磁共振成像(MRI)、遗传、神经感觉、临床、脑脊液和认知数据。我们现在分享一个新的版本,包括6年的额外随访认知数据,额外的MRI随访,临床进展,新的纵向行为和生活方式测量(问卷调查,活动记录仪),纵向AD血浆生物标志物,淀粉样蛋白- β和tau正电子发射断层扫描(PET),脑磁图,以及所有MRI模式的神经成像分析测量。我们介绍了prevention - ad研究,与全球研究界共享的数据,以及我们为维持纵向随访而创建的模型,同时也允许新的创新数据收集。重点:阿尔茨海默病的实验性或新型治疗的症状前评估(prevention - ad)是一项单点纵向研究,于2011年开始,每年对入组时认知正常的阿尔茨海默病风险个体进行随访数据收集。所有387名参与者在2011年至2017年期间入组,截至2023年12月,其中306名(79%)仍在研究中。虽然prevention - ad数据集最初并没有计划与全球研究界共享,但348名参与者回顾性地同意与全球研究人员共享他们的数据。第一次发布数据是在2019年。我们现在分享第二个版本,包括6年的额外随访,临床进展信息和新的认知,行为,遗传,血浆和神经成像(淀粉样蛋白和tau正电子发射断层扫描[PET],脑磁成像[MEG]和新的磁共振成像[MRI]序列)数据。它还包括神经成像模式的分析输出。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The PREVENT-AD cohort: Accelerating Alzheimer's disease research and treatment in Canada and beyond.

The PResymptomatic EValuation of Experimental or Novel Treatments for Alzheimer's Disease (PREVENT-AD) is an investigator-driven study that was created in 2011 and enrolled cognitively normal older adults with a family history of sporadic AD. Participants are deeply phenotyped and have now been followed annually for more than 12 years (median follow-up 8.0 years, SD 3.1). Multimodal magnetic resonance imaging (MRI), genetic, neurosensory, clinical, cerebrospinal fluid, and cognitive data collected until 2017 on 348 participants who agreed to open sharing with the neuroscience community were already available. We now share a new release including 6 years of additional follow-up cognitive data, and additional MRI follow-ups, clinical progression, new longitudinal behavioral and lifestyle measures (questionnaires, actigraphy), longitudinal AD plasma biomarkers, amyloid-beta and tau positron emission tomography (PET), magnetoencephalography, as well as neuroimaging analytic measures from all MRI modalities. We describe the PREVENT-AD study, the data shared with the global research community, as well as the model we created to sustain longitudinal follow-ups while also allowing new innovative data collection. HIGHLIGHTS: The PResymptomatic EValuation of Experimental or Novel Treatments for Alzheimer's Disease (PREVENT-AD) is a single-site longitudinal study that started in 2011 with annual follow-up data collection on individuals at risk of Alzheimer's disease who were all cognitively normal at enrolment. All 387 participants were enrolled between 2011 and 2017 and 306 (79%) of these participants were still in the study as of December 2023. While the PREVENT-AD dataset was not originally planned to be shared with the global research community, 348 participants retrospectively consented for their data to be shared with researchers worldwide. The first release of data was in 2019. We now share a second release that includes 6 years of additional follow-up visits, information on clinical progression and novel cognitive, behavioral, genetic, plasma and neuroimaging (amyloid and tau positron emission tomography [PET], magnetoencephalography [MEG], and new magnetic resonance imaging [MRI] sequences) data. It also includes analytic outputs for neuroimaging modalities.

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来源期刊
Alzheimer's & Dementia
Alzheimer's & Dementia 医学-临床神经学
CiteScore
14.50
自引率
5.00%
发文量
299
审稿时长
3 months
期刊介绍: Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.
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