一种内质网靶向NIR-II型AIE光敏剂，可引发焦亡。

IF 4.2 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemical Communications Pub Date : 2025-09-29 DOI:10.1039/d5cc04652a

Xinyu Li, Lijin Yang, Bingbing He, Dongxiu Li, Changqing Lei, Nan Li, Na Zhao

引用次数: 0

摘要

在这项工作中，我们开发了一种内质网靶向NIR-II光敏剂（TI-ER），它具有I型ROS生成和光热能力。TI-ER纳米颗粒被制成纳米颗粒后，在635 nm激光照射下被癌细胞有效内化并诱导焦亡，有效地消融癌细胞和多细胞肿瘤球体。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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An endoplasmic reticulum-targeted NIR-II type I AIE photosensitiser for triggering pyroptosis.

In this work, we developed an endoplasmic reticulum-targeted NIR-II photosensitizer (TI-ER), which exhibits type I ROS generation and photothermal capabilities. After formulation into nanoparticles (NPs), TI-ER NPs were efficiently internalized by cancer cells and induced pyroptosis under 635 nm laser irradiation, efficiently ablating both cancer cells and multicellular tumor spheroids.

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来源期刊

Chemical Communications 化学-化学综合

CiteScore

8.60

自引率

4.10%

发文量

2705

审稿时长

1.4 months

期刊介绍： ChemComm (Chemical Communications) is renowned as the fastest publisher of articles providing information on new avenues of research, drawn from all the world''s major areas of chemical research.