[雄激素替代和性腺功能减退联合治疗后射精质量的恢复]。

E R Rozhivanova, R V Rozhivanov, E N Andreeva, G А Mel'nichenko, N G Mokrysheva
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引用次数: 0

摘要

背景:优化男性性腺功能减退的雄激素替代疗法,以改善生殖前景。目的:比较雄激素替代疗法(AZT)与绒毛膜促性腺激素(AZT/HG)联合治疗对恢复男性射精质量的效果。材料和方法:观察性前瞻性研究纳入53名男性,在国家内分泌医学研究中心观察5年以上,AZT (n=19)或AZT/HG (n=34),随后刺激促性腺激素治疗。对所有患者的射精质量参数进行评价。差异有统计学意义的基本水平为p<;0,05。结果:两组患者在年龄、BMI、治疗持续时间、睾酮制剂类型以及性腺功能减退的病因方面具有可比性。AZT组精子浓度呈负动态变化,差异有统计学意义,ART/HG组精子浓度变化无统计学意义。精子浓度变化值差异有统计学意义。两组在精子活力和形态上均观察到统计学上显著的负动态。两组精子活力和形态变化值差异无统计学意义。结论:与雄激素替代治疗相比,睾酮与绒毛膜促性腺激素联合治疗在精子浓度恢复方面效果更好。对于精子活力和形态的恢复,两种方法的效果都不理想。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Restoration of ejaculate quality following androgen replacement and combined therapy for hypogonadism].

Background: To optimize androgen replacement therapy for male hypogonadism to improve reproductive prospects.

Aim: To compare the effectiveness of restoring the quality of ejaculate in men receiving androgen replacement therapy (AZT) and patients receiving course combination therapy with testosterone and chorionic gonadotropin (AZT/HG).

Materials and methods: In observational prospective study was included 53 men observed at The National Medical Research Center for Endocrinology and AZT (n=19) or AZT/HG (n=34) more than 5 years, followed by stimulating gonadotropin therapy. The qualitative parameters of ejaculate were evaluated in all patients. The basic level of statistical significance was p<0,05.

Results: The patient groups were comparable in age, BMI, duration of therapy used, type of testosterone preparation, as well as the etiology of hypogonadism. Sperm concentration in the AZT group there was a statistically significant negative dynamics, while in the ART/HG group, there were no statistically significant differences in the dynamics of sperm concentration. Statistically significant differences in the value of sperm concentration change were revealed. In both groups was observed statistically significant negative dynamics for sperm motility and morphology. There were no statistically significant differences in the value of changes motility and sperm morphology in both studied groups.

Conclusion: Course combination therapy with testosterone and chorionic gonadotropin is characterized by better results for sperm concentration restoration compared with androgenic replacement therapy. For the restoration of sperm motility and morphology both methods do not show satisfactory results.

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