A Comparison of 24-2C SITA Faster and 10-2 SITA Standard for Detecting Damage in the Macula in Mild-Stage Glaucoma.

Purpose: To compare the diagnostic accuracy of 24-2C SITA Faster and 10-2 SITA Standard in detecting macular damage in mild-stage glaucoma.

Design: Multicenter diagnostic accuracy study based on prospectively collected data.

Participants: In total, 108 eyes from 108 patients with mild-stage glaucoma (normal tension glaucoma, 58; high tension glaucoma, 50) and 52 eyes from 52 healthy controls at the Jikei University School of Medicine and Tajimi Iwase Eye Clinic.

Methods: Participants underwent 24-2C SITA Faster and 10-2 SITA Standard visual field testing on the same day, in randomized order. Optical coherence tomography with ganglion cell analysis identified macular damage. McNemar's test and non-inferiority analysis (10% margin) compared detection accuracy. Test durations were compared using pairwise t-tests.

Main outcome measures: Sensitivity and specificity of 24-2C SITA Faster and 10-2 SITA Standard for detecting macular damage, and test duration.

Results: For overall macular damage, 24-2C SITA Faster demonstrated sensitivity/specificity of 0.64/0.93 (total deviation [TD]) and 0.67/0.93 (pattern deviation [PD]), while 10-2 SITA Standard demonstrated 0.69/0.94 (TD) and 0.77/0.93 (PD). McNemar's test revealed no significant difference, and 24-2C SITA Faster was non-inferior within the 10% margin. Sub-analysis with a strict 5% margin, revealed that 10-2 SITA Standard was superior to 24-2C SITA Faster when using PD plot for all parameters. Mean test duration was significantly shorter for 24-2C SITA Faster (158.5 seconds) than for 10-2 SITA Standard (330.0 seconds; p < 0.001).

Conclusions: 24-2C SITA Faster is a non-inferior and more time-efficient alternative to 10-2 SITA Standard for detecting macular damage in mild-stage glaucoma; however, 10-2 SITA Standard may be considered superior for detecting subtle macular defects using PD.