多维建模以最大限度地适应运动:M3AX试验的基本原理和研究设计。

IF 3.3 3区 医学 Q1 PHYSIOLOGY
Zachary A Graham, Matthew P Bubak, Christiana J Raymond-Pope, Gary R Cutter, Jeremy S McAdam, S Craig Tuggle, Jacob A Siedlik, Luis G O de Sousa, Ed J Chappe, Kana Meece, Amritpal Kaur, Benny S R Ruiz, Sophia C Bamman, Katherine M Vanselow, Trevor W Perry, Jorge S Acosta-Arreguin, Natalie J Bohmke, Greg J Addison, J Michelle Bowers, Rachel L Wright, Lena D Fuentes, Jennifer E Smith, Karyn A Esser, Benjamin F Miller, Sue C Bodine, Marcas M Bamman
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引用次数: 0

摘要

与年龄相关的功能衰退被认为是由身体、精神和代谢损伤等标志性生物过程引起的,这些过程损害了内在能力、健康寿命和生活质量。运动是一种多能疗法,有望缓解大多数衰老特征,但个体运动反应性存在很大差异。这种个体间反应异质性(IRH)首先由Bouchard及其同事在耐力训练的背景下广泛研究。我们的团队研究了IRH对抗阻训练和联合训练的反应,我们在老年人中进行了试验,检查了剂量滴定和辅助治疗,试图提高反应率。尽管许多团体开展了工作,但支持IRH的机制和有效的缓解战略在很大程度上仍然难以捉摸。美国国家老龄化研究所(NIA)于2022年举办了一场专题研讨会,题为“了解老年人运动训练反应的异质性,并优化临床疗效”。这次研讨会激发了一个专门的NIA申请(RFA),其主要目标是“更好地了解老年人运动训练反应变异性的潜在因素”。为了响应RFA,我们开发了一项两阶段的顺序多分配随机试验(SMART),该试验将允许我们对个体对耐力和阻力联合训练的反应性进行分类,并询问潜在的机制基础(第一阶段),然后是提高反应性的方法(第二阶段)。通过深入体内、离体和分子表型分析,我们将建立多维反应性生物回路并建立预测模型,为个性化运动处方提供基础。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Multidimensional Modeling to Maximize Adaptations to eXercise: The M3AX Trial Rationale and Study Design.

Age-related functional declines are thought to be caused by hallmark biological processes that manifest in physical, mental, and metabolic impairments compromising intrinsic capacity, healthspan and quality-of-life. Exercise is a multipotent treatment with promise to mitigate most aging hallmarks, but there is substantial variability in individual exercise responsiveness. This inter-individual response heterogeneity (IRH) was first extensively interrogated by Bouchard and colleagues in the context of endurance training. Our group has interrogated IRH in response to resistance training and combined training, and we have conducted trials in older adults examining dose titration and adjuvant treatments in attempts to boost response rates. Despite the work of many groups, the mechanisms underpinning IRH and effective mitigation strategies largely remain elusive. The National Institute on Aging (NIA) hosted a focused workshop in 2022 titled "Understanding heterogeneity of responses to, and optimizing clinical efficacy of, exercise training in old adults". This workshop spurred a dedicated NIA request for applications (RFA) with the major goal "to better understand factors underlying response variability to exercise training in older adults." We developed a two-phase Sequential Multiple Assignment Randomized Trial (SMART) in response to the RFA that will allow us to classify individual responsiveness to combined endurance and resistance training and interrogate potential mechanistic underpinnings (Phase I), followed by an approach to boost responsiveness (Phase II). Using deep in vivo, ex vivo, and molecular phenotyping, we will establish multidimensional biocircuitry of responsiveness and build predictive models, providing a basis for personalized exercise prescriptions.

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来源期刊
CiteScore
6.00
自引率
9.10%
发文量
296
审稿时长
2-4 weeks
期刊介绍: The Journal of Applied Physiology publishes the highest quality original research and reviews that examine novel adaptive and integrative physiological mechanisms in humans and animals that advance the field. The journal encourages the submission of manuscripts that examine the acute and adaptive responses of various organs, tissues, cells and/or molecular pathways to environmental, physiological and/or pathophysiological stressors. As an applied physiology journal, topics of interest are not limited to a particular organ system. The journal, therefore, considers a wide array of integrative and translational research topics examining the mechanisms involved in disease processes and mitigation strategies, as well as the promotion of health and well-being throughout the lifespan. Priority is given to manuscripts that provide mechanistic insight deemed to exert an impact on the field.
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