Lauroyl Lysine Continuous Injection Synthesis via Schotten–Baumann Reaction pH Optimization as Synthetic Amino Acid Derivative

This research focuses on identifying optimal synthesis conditions for lauroyl lysine, an amino acid derivative widely used in the cosmetics industry. The effect of pH on reaction rate and selectivity was quantitatively assessed through systematic variations within the range between pH 10 and pH 13, and the reaction conditions were subject to a continuous slow precursor injection technique as alternative to batch-type reaction. This results in optimal pH conditions and the establishment of a synthesis via Schotten–Baumann reaction process on a laboratory scale, yielding from 97.77 to 55.20% range. This study will contribute to maximizing the industrial scale-up synthesis efficiency of lauroyl lysine and expanding its application potential in the cosmetics industry, reducing manufacturing costs and expect the possibility of commercial production.