气泡辅助提取红豆杉生物质紫杉醇的动力学建模及机理研究

IF 3.2 4区 工程技术 Q2 CHEMISTRY, MULTIDISCIPLINARY
Jong-Min Park, Yeji Kang, Jin-Hyun Kim
{"title":"气泡辅助提取红豆杉生物质紫杉醇的动力学建模及机理研究","authors":"Jong-Min Park,&nbsp;Yeji Kang,&nbsp;Jin-Hyun Kim","doi":"10.1007/s11814-025-00525-x","DOIUrl":null,"url":null,"abstract":"<div><p>In this study, the extraction efficiency, extraction kinetics, and extraction mechanism according to bubble size in gas bubble-assisted extraction were investigated to recover paclitaxel efficiently from <i>Taxus chinensis</i>. When the bubble diameters were 2.3, 2.7, 3.0, 3.3, 3.7, 4.1, 4.5, 4.8, and 5.3 mm, the maximum extracted paclitaxel concentrations were 0.812, 0.830, 0.845, 0.850, 0.868, 0.876, 0.900, 0.916, and 0.933 mg/mL, respectively. The results indicated that the paclitaxel yield increased as the bubble diameter increased during extraction. Most of the paclitaxel (&gt; 93.3%) could be recovered by a one-time extraction when the bubble diameters were greater than 5.3 mm. The extraction mechanism demonstrated that the bubbles collapsed at the surface of the extraction solution and created shockwaves that strongly impacted the biomass, which disrupted the cells. When the extracted data were applied to various empirical models (second-order model, parabolic diffusion model, power law model, and logarithmic model), the second-order model was found to be the most suitable. In addition, a model that can predict the concentration of extracted paclitaxel was proposed using regression analysis of the equilibrium concentration and initial extraction rate according to the bubble diameter. The experimental data and the predicted data were found to be in agreement.</p></div>","PeriodicalId":684,"journal":{"name":"Korean Journal of Chemical Engineering","volume":"42 12","pages":"2821 - 2833"},"PeriodicalIF":3.2000,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Kinetic Modeling and Mechanism of the Gas Bubble-Assisted Extraction of Paclitaxel from Biomass of Taxus chinensis\",\"authors\":\"Jong-Min Park,&nbsp;Yeji Kang,&nbsp;Jin-Hyun Kim\",\"doi\":\"10.1007/s11814-025-00525-x\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>In this study, the extraction efficiency, extraction kinetics, and extraction mechanism according to bubble size in gas bubble-assisted extraction were investigated to recover paclitaxel efficiently from <i>Taxus chinensis</i>. When the bubble diameters were 2.3, 2.7, 3.0, 3.3, 3.7, 4.1, 4.5, 4.8, and 5.3 mm, the maximum extracted paclitaxel concentrations were 0.812, 0.830, 0.845, 0.850, 0.868, 0.876, 0.900, 0.916, and 0.933 mg/mL, respectively. The results indicated that the paclitaxel yield increased as the bubble diameter increased during extraction. Most of the paclitaxel (&gt; 93.3%) could be recovered by a one-time extraction when the bubble diameters were greater than 5.3 mm. The extraction mechanism demonstrated that the bubbles collapsed at the surface of the extraction solution and created shockwaves that strongly impacted the biomass, which disrupted the cells. When the extracted data were applied to various empirical models (second-order model, parabolic diffusion model, power law model, and logarithmic model), the second-order model was found to be the most suitable. In addition, a model that can predict the concentration of extracted paclitaxel was proposed using regression analysis of the equilibrium concentration and initial extraction rate according to the bubble diameter. The experimental data and the predicted data were found to be in agreement.</p></div>\",\"PeriodicalId\":684,\"journal\":{\"name\":\"Korean Journal of Chemical Engineering\",\"volume\":\"42 12\",\"pages\":\"2821 - 2833\"},\"PeriodicalIF\":3.2000,\"publicationDate\":\"2025-07-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Korean Journal of Chemical Engineering\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s11814-025-00525-x\",\"RegionNum\":4,\"RegionCategory\":\"工程技术\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Korean Journal of Chemical Engineering","FirstCategoryId":"5","ListUrlMain":"https://link.springer.com/article/10.1007/s11814-025-00525-x","RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0

摘要

以红豆杉为原料,研究了气泡辅助提取中紫杉醇的提取效率、提取动力学及不同气泡大小的提取机理。泡直径为2.3、2.7、3.0、3.3、3.7、4.1、4.5、4.8和5.3 mm时,紫杉醇的最大提取浓度分别为0.812、0.830、0.845、0.850、0.868、0.876、0.900、0.916和0.933 mg/mL。结果表明,紫杉醇提取率随泡直径的增大而增大。当泡直径大于5.3 mm时,一次性提取可回收大部分紫杉醇(93.3%)。提取机制表明,气泡在提取液表面破裂,产生强烈冲击生物质的冲击波,破坏细胞。将提取的数据应用于各种经验模型(二阶模型、抛物扩散模型、幂律模型和对数模型),发现二阶模型是最合适的。此外,根据气泡直径对平衡浓度和初始提取率进行回归分析,建立了预测提取紫杉醇浓度的模型。实验数据与预测数据吻合较好。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Kinetic Modeling and Mechanism of the Gas Bubble-Assisted Extraction of Paclitaxel from Biomass of Taxus chinensis

Kinetic Modeling and Mechanism of the Gas Bubble-Assisted Extraction of Paclitaxel from Biomass of Taxus chinensis

In this study, the extraction efficiency, extraction kinetics, and extraction mechanism according to bubble size in gas bubble-assisted extraction were investigated to recover paclitaxel efficiently from Taxus chinensis. When the bubble diameters were 2.3, 2.7, 3.0, 3.3, 3.7, 4.1, 4.5, 4.8, and 5.3 mm, the maximum extracted paclitaxel concentrations were 0.812, 0.830, 0.845, 0.850, 0.868, 0.876, 0.900, 0.916, and 0.933 mg/mL, respectively. The results indicated that the paclitaxel yield increased as the bubble diameter increased during extraction. Most of the paclitaxel (> 93.3%) could be recovered by a one-time extraction when the bubble diameters were greater than 5.3 mm. The extraction mechanism demonstrated that the bubbles collapsed at the surface of the extraction solution and created shockwaves that strongly impacted the biomass, which disrupted the cells. When the extracted data were applied to various empirical models (second-order model, parabolic diffusion model, power law model, and logarithmic model), the second-order model was found to be the most suitable. In addition, a model that can predict the concentration of extracted paclitaxel was proposed using regression analysis of the equilibrium concentration and initial extraction rate according to the bubble diameter. The experimental data and the predicted data were found to be in agreement.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Korean Journal of Chemical Engineering
Korean Journal of Chemical Engineering 工程技术-工程:化工
CiteScore
4.60
自引率
11.10%
发文量
310
审稿时长
4.7 months
期刊介绍: The Korean Journal of Chemical Engineering provides a global forum for the dissemination of research in chemical engineering. The Journal publishes significant research results obtained in the Asia-Pacific region, and simultaneously introduces recent technical progress made in other areas of the world to this region. Submitted research papers must be of potential industrial significance and specifically concerned with chemical engineering. The editors will give preference to papers having a clearly stated practical scope and applicability in the areas of chemical engineering, and to those where new theoretical concepts are supported by new experimental details. The Journal also regularly publishes featured reviews on emerging and industrially important subjects of chemical engineering as well as selected papers presented at international conferences on the subjects.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信