糖尿病及其慢性并发症患者硫醇/二硫体内平衡的改变。

IF 2.3 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Archives of Endocrinology Metabolism Pub Date : 2025-09-26 DOI:10.20945/2359-4292-2025-0042

Nuri Aslanoğlu, Şakir Özgür Keşkek, Salim Neşelioğlu, Funda Eren

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引用次数: 0

摘要

目的：探讨糖尿病及其慢性并发症对硫醇/二硫体内平衡的影响。方法：研究纳入381例受试者，分为6组：健康对照组（1组，n = 91）、糖尿病前期患者（2组，n = 50）、糖尿病无并发症患者（3组，n = 70）、糖尿病视网膜病变患者（4组，n = 47）、糖尿病肾病患者（5组，n = 70）、糖尿病足患者（6组，n = 53）。通过测定氧化硫醇的还原反应来确定硫醇/二硫化物的稳态。结果：糖尿病并发症患者体内硫醇水平较低（第4组264.7±58.5µmol/L，第5组246.6±67.5µmol/L，第6组174.3±65.9µmol/L），总硫醇水平较低。第1组（对照组，20.4±5.2µmol/L）和第6组（16.2±5.7µmol/L）的二硫化物含量最高和最低。与1、2、3组相比，第4、5、6组的二硫/天然硫醇比均有所增加。结论：糖尿病并发症的存在显著降低了天然硫醇、总硫醇和二硫化物水平。

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Altered thiol/disulfide homeostasis in patients with diabetes mellitus and its chronic complications.

Objective: To evaluate the effect of diabetes mellitus and its chronic complications on thiol/disulfide homeostasis.

Methods: The study included 381 participants divided into six groups: healthy controls (Group 1; n = 91), patients with prediabetes (Group 2; n = 50), patients with diabetes mellitus without complications (Group 3; n = 70), patients with diabetic retinopathy (Group 4; n = 47), patients with diabetic nephropathy (Group 5; n = 70), and patients with diabetic foot (Group 6; n = 53). Thiol/disulfide homeostasis was determined by measuring the reduction reaction of oxidized thiols.

Results: Native thiol levels were low in patients with diabetes mellitus complications (Group 4, 264.7 ± 58.5 µmol/L; Group 5, 246.6 ± 67.5 µmol/L; Group 6, 174.3 ± 65.9 µmol/L), as were total thiol levels. The highest and lowest disulfide levels were observed in Group 1 (controls; 20.4 ± 5.2 µmol/L) and Group 6 (16.2 ± 5.7 µmol/L), respectively. The disulfide/native thiol ratio was increased in Groups 4, 5, and 6 compared with Groups 1, 2, and 3.

Conclusion: The presence of diabetes mellitus complications substantially decreased native thiol, total thiol, and disulfide levels.

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来源期刊

Archives of Endocrinology Metabolism Medicine-Endocrinology, Diabetes and Metabolism

CiteScore

2.90

自引率

5.90%

发文量

107

审稿时长

7 weeks

期刊介绍： The Archives of Endocrinology and Metabolism - AE&M – is the official journal of the Brazilian Society of Endocrinology and Metabolism - SBEM, which is affiliated with the Brazilian Medical Association. Edited since 1951, the AE&M aims at publishing articles on scientific themes in the basic translational and clinical area of Endocrinology and Metabolism. The printed version AE&M is published in 6 issues/year. The full electronic issue is open access in the SciELO - Scientific Electronic Library Online e at the AE&M site: www.aem-sbem.com. From volume 59 on, the name was changed to Archives of Endocrinology and Metabolism, and it became mandatory for manuscripts to be submitted in English for the online issue. However, for the printed issue it is still optional for the articles to be sent in English or Portuguese. The journal is published six times a year, with one issue every two months.