{"title":"改良Cabrol技术在主动脉根部置换术中的效果:早期和中期经验。","authors":"Nayeem Nasher, Joshua Chen, Purab Kothari, Colin King, Jacqueline McGee, Vishal Shah, Saarah Khairi, Konstadinos Plestis","doi":"10.1093/icvts/ivaf235","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>The modified Cabrol technique has been associated with excellent graft patency. However, prior studies were limited to patients largely on long-term anticoagulation. We sought to analyze outcomes in patients primarily managed without mechanical prostheses.</p><p><strong>Methods: </strong>We retrospectively analyzed all patients who underwent aortic root replacement by a single surgeon from 2014 to 2024. Patients who underwent reimplantation of one or both coronary ostia using the modified Cabrol technique with separate interposition grafts were identified. Baseline characteristics and postoperative outcomes were reported. Predictors of mortality were analyzed using Cox proportional hazards, and overall survival was reported using Kaplan-Meier analysis.</p><p><strong>Results: </strong>We identified 91 patients who underwent the modified Cabrol technique. The median age was 62 [interquartile range, 52-71] years, and 91.2% (83/91) were male. Patients presented urgently or emergently in 38.5% (35/91) of cases, and for acute dissection in 23.1% (21/91) of cases, and endocarditis in 15.4% (14/91). Patients required redo sternotomy in 50% of cases. A mechanical composite valve graft was used in only 7.7% (7/91) of patients. The incidence of long-term myocardial infarction was 4.4% (4/91). Survival at 1 and 5 years was 93% and 89% respectively. There was no significant association with the utilization of Cabrol graft and long-term mortality (Hazard Ratio 1.74, 95% CI 0.76-4.01, p-value 0.219).</p><p><strong>Conclusions: </strong>Patients undergoing the modified Cabrol technique had an acceptable risk of mortality in short- and midterm follow-up. The modified Cabrol technique is a valuable tool in an aortic surgeon's arsenal and should be used selectively.</p>","PeriodicalId":73406,"journal":{"name":"Interdisciplinary cardiovascular and thoracic surgery","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12513762/pdf/","citationCount":"0","resultStr":"{\"title\":\"Outcomes of the modified Cabrol technique in aortic root replacement: Early and midterm experience.\",\"authors\":\"Nayeem Nasher, Joshua Chen, Purab Kothari, Colin King, Jacqueline McGee, Vishal Shah, Saarah Khairi, Konstadinos Plestis\",\"doi\":\"10.1093/icvts/ivaf235\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objectives: </strong>The modified Cabrol technique has been associated with excellent graft patency. However, prior studies were limited to patients largely on long-term anticoagulation. We sought to analyze outcomes in patients primarily managed without mechanical prostheses.</p><p><strong>Methods: </strong>We retrospectively analyzed all patients who underwent aortic root replacement by a single surgeon from 2014 to 2024. Patients who underwent reimplantation of one or both coronary ostia using the modified Cabrol technique with separate interposition grafts were identified. Baseline characteristics and postoperative outcomes were reported. Predictors of mortality were analyzed using Cox proportional hazards, and overall survival was reported using Kaplan-Meier analysis.</p><p><strong>Results: </strong>We identified 91 patients who underwent the modified Cabrol technique. The median age was 62 [interquartile range, 52-71] years, and 91.2% (83/91) were male. Patients presented urgently or emergently in 38.5% (35/91) of cases, and for acute dissection in 23.1% (21/91) of cases, and endocarditis in 15.4% (14/91). Patients required redo sternotomy in 50% of cases. A mechanical composite valve graft was used in only 7.7% (7/91) of patients. The incidence of long-term myocardial infarction was 4.4% (4/91). Survival at 1 and 5 years was 93% and 89% respectively. There was no significant association with the utilization of Cabrol graft and long-term mortality (Hazard Ratio 1.74, 95% CI 0.76-4.01, p-value 0.219).</p><p><strong>Conclusions: </strong>Patients undergoing the modified Cabrol technique had an acceptable risk of mortality in short- and midterm follow-up. The modified Cabrol technique is a valuable tool in an aortic surgeon's arsenal and should be used selectively.</p>\",\"PeriodicalId\":73406,\"journal\":{\"name\":\"Interdisciplinary cardiovascular and thoracic surgery\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-09-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12513762/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Interdisciplinary cardiovascular and thoracic surgery\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1093/icvts/ivaf235\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"0\",\"JCRName\":\"CARDIAC & CARDIOVASCULAR SYSTEMS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Interdisciplinary cardiovascular and thoracic surgery","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1093/icvts/ivaf235","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"0","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
引用次数: 0
摘要
目的:改良Cabrol技术具有良好的移植物通畅性。然而,先前的研究主要局限于长期抗凝治疗的患者。我们试图分析主要不使用机械假体的患者的结果。方法:回顾性分析2014年至2024年间由同一位外科医生行主动脉根置换术的所有患者。使用改良的Cabrol技术和单独的间置移植物进行一个或两个冠状动脉口再植的患者被确定。报告基线特征和术后结果。死亡率预测因子采用Cox比例风险分析,总生存率采用Kaplan-Meier分析。结果:我们确定了91例接受改良Cabrol技术的患者。年龄中位数为62岁[四分位数间距52 ~ 71],男性占91.2%(83/91)。38.5%(35/91)的患者表现为急症或急诊,23.1%(21/91)的患者表现为急性夹层,15.4%(14/91)的患者表现为心内膜炎。50%的患者需要重新进行胸骨切开术。机械复合瓣膜移植仅占7.7%(7/91)。长期心肌梗死发生率为4.4%(4/91)。1年和5年生存率分别为93%和89%。Cabrol移植物的使用与长期死亡率无显著相关性(风险比1.74,95% CI 0.76-4.01, p值0.219)。结论:接受改良Cabrol技术的患者在短期和中期随访中有可接受的死亡风险。改良的Cabrol技术在主动脉外科医生的武器库中是一个有价值的工具,应该有选择地使用。
Outcomes of the modified Cabrol technique in aortic root replacement: Early and midterm experience.
Objectives: The modified Cabrol technique has been associated with excellent graft patency. However, prior studies were limited to patients largely on long-term anticoagulation. We sought to analyze outcomes in patients primarily managed without mechanical prostheses.
Methods: We retrospectively analyzed all patients who underwent aortic root replacement by a single surgeon from 2014 to 2024. Patients who underwent reimplantation of one or both coronary ostia using the modified Cabrol technique with separate interposition grafts were identified. Baseline characteristics and postoperative outcomes were reported. Predictors of mortality were analyzed using Cox proportional hazards, and overall survival was reported using Kaplan-Meier analysis.
Results: We identified 91 patients who underwent the modified Cabrol technique. The median age was 62 [interquartile range, 52-71] years, and 91.2% (83/91) were male. Patients presented urgently or emergently in 38.5% (35/91) of cases, and for acute dissection in 23.1% (21/91) of cases, and endocarditis in 15.4% (14/91). Patients required redo sternotomy in 50% of cases. A mechanical composite valve graft was used in only 7.7% (7/91) of patients. The incidence of long-term myocardial infarction was 4.4% (4/91). Survival at 1 and 5 years was 93% and 89% respectively. There was no significant association with the utilization of Cabrol graft and long-term mortality (Hazard Ratio 1.74, 95% CI 0.76-4.01, p-value 0.219).
Conclusions: Patients undergoing the modified Cabrol technique had an acceptable risk of mortality in short- and midterm follow-up. The modified Cabrol technique is a valuable tool in an aortic surgeon's arsenal and should be used selectively.