血红蛋白、白蛋白、淋巴细胞和血小板评分作为二尖瓣黏液瘤病继发充血性心力衰竭犬的预后指标

IF 2.3 2区 农林科学 Q2 VETERINARY SCIENCES
Jayeon Park, Yeon Chae, Sungjae Lee, Yoonhoi Koo, Hakhyun Kim, Byeong-Teck Kang, Taesik Yun
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引用次数: 0

摘要

犬二尖瓣黏液瘤病(MMVD)继发充血性心力衰竭(CHF)的可靠预后指标有限。作为人类预后指标的血红蛋白、白蛋白、淋巴细胞和血小板(HALP)评分尚未在兽医学中得到评估。本研究旨在评估HALP评分在预测MMVD所致CHF犬的短期死亡率方面的效用。这项回顾性研究包括54只小型犬。HALP评分计算公式为:血红蛋白(g/L) ×白蛋白(g/L) ×淋巴细胞(/L)/血小板(/L)。评估了6个月、9个月和1年的死亡率。幸存者组的HALP评分明显较高。受试者工作特征(ROC)分析显示对6个月和9个月死亡率的预测准确性良好(曲线下面积> 0.7)。6个月死亡率的截止值为11.13,敏感性为44.44%,特异性为94.44%。Kaplan-Meier分析证实,较高的HALP评分与较长的生存期显著相关。HALP评分似乎是一种有价值的、新的预测MMVD所致CHF犬短期死亡率的指标。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Hemoglobin, Albumin, Lymphocyte, and Platelet Score as a Prognostic Indicator for Dogs with Congestive Heart Failure Secondary to Myxomatous Mitral Valve Disease.

Reliable prognostic indicators for congestive heart failure (CHF) secondary to myxomatous mitral valve disease (MMVD) in dogs are limited. The hemoglobin, albumin, lymphocyte, and platelet (HALP) score, a prognostic marker in humans, has not been evaluated in veterinary medicine. This study aimed to assess the HALP score's utility for predicting short-term mortality in dogs with CHF due to MMVD. This retrospective study included 54 small-breed dogs. The HALP score was calculated as: hemoglobin (g/L) × albumin (g/L) × lymphocytes (/L)/platelets (/L). Six-, nine-month, and one-year mortality were assessed. The HALP score was significantly higher in survivor groups. Receiver operating characteristic (ROC) analysis showed good predictive accuracy for six- and nine-month mortality (area under the curve > 0.7). A cut-off of 11.13 for six-month mortality yielded 44.44% sensitivity and 94.44% specificity. Kaplan-Meier analysis confirmed that a higher HALP score was associated with significantly longer survival. The HALP score appears to be a valuable, novel prognostic indicator for short-term mortality in dogs with CHF due to MMVD.

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来源期刊
Veterinary Sciences
Veterinary Sciences VETERINARY SCIENCES-
CiteScore
2.90
自引率
8.30%
发文量
612
审稿时长
6 weeks
期刊介绍: Veterinary Sciences is an international and interdisciplinary scholarly open access journal. It publishes original that are relevant to any field of veterinary sciences, including prevention, diagnosis and treatment of disease, disorder and injury in animals. This journal covers almost all topics related to animal health and veterinary medicine. Research fields of interest include but are not limited to: anaesthesiology anatomy bacteriology biochemistry cardiology dentistry dermatology embryology endocrinology epidemiology genetics histology immunology microbiology molecular biology mycology neurobiology oncology ophthalmology parasitology pathology pharmacology physiology radiology surgery theriogenology toxicology virology.
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