Yuexin Lu, Jiahao Tang, Rong Zou, Chaobo Zheng, Ming Wang, Jianping Xiang, Shu Wan
{"title":"AneuGuide™软件辅助分流器治疗复杂颅内动脉瘤的单中心经验","authors":"Yuexin Lu, Jiahao Tang, Rong Zou, Chaobo Zheng, Ming Wang, Jianping Xiang, Shu Wan","doi":"10.1016/j.wneu.2025.124501","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To investigate the efficacy and safety of flow diverters (FDs) guided by AneuGuide™ software in treating complex intracranial aneurysms.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on 45 patients diagnosed with 48 complex intracranial aneurysms from August 2019 to December 2023. Among these, 21 aneurysms were treated with FDs implantation guided by AneuGuide™ software (ArteryFlow Technology, Hangzhou, China), and 27 aneurysms received FDs treatment without AneuGuide™ assistance. Immediate post-operative embolization rates, complication incidences, and clinical and imaging follow-up results were compared between the two groups.</p><p><strong>Results: </strong>A total of 49 FDs were implanted for the 48 aneurysms in the 45 patients, with 10 patients receiving additional coil embolization. No perioperative complications occurred. At 1-year follow-up, angiography showed: 9 aneurysms (18.8%) were grade B (partially visible), and 39 aneurysms (81.3%) were grade C or D (near-total occlusion), of which 37 (77.1%) were completely occluded (grade D). Multivariate cox regression analysis revealed that the AneuGuide™ group had a significantly higher complete occlusion rate at follow-up compared to the non-AneuGuide™ group (HR = 2.290, p = 0.044). One patient in the non-AneuGuide™ group developed in-stent stenosis without clinical symptoms. No new neurological deficits were observed in any of the patients during the follow-up period.</p><p><strong>Conclusion: </strong>FD placement for complex intracranial aneurysms assisted by AneuGuide™ software is a safe and effective treatment. Further prospective studies are needed to validate these findings.</p>","PeriodicalId":23906,"journal":{"name":"World neurosurgery","volume":" ","pages":"124501"},"PeriodicalIF":2.1000,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Single-Center Experience with AneuGuide™ Software-Assisted Flow Diverter Treatment for Complex Intracranial Aneurysms.\",\"authors\":\"Yuexin Lu, Jiahao Tang, Rong Zou, Chaobo Zheng, Ming Wang, Jianping Xiang, Shu Wan\",\"doi\":\"10.1016/j.wneu.2025.124501\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To investigate the efficacy and safety of flow diverters (FDs) guided by AneuGuide™ software in treating complex intracranial aneurysms.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on 45 patients diagnosed with 48 complex intracranial aneurysms from August 2019 to December 2023. Among these, 21 aneurysms were treated with FDs implantation guided by AneuGuide™ software (ArteryFlow Technology, Hangzhou, China), and 27 aneurysms received FDs treatment without AneuGuide™ assistance. Immediate post-operative embolization rates, complication incidences, and clinical and imaging follow-up results were compared between the two groups.</p><p><strong>Results: </strong>A total of 49 FDs were implanted for the 48 aneurysms in the 45 patients, with 10 patients receiving additional coil embolization. No perioperative complications occurred. At 1-year follow-up, angiography showed: 9 aneurysms (18.8%) were grade B (partially visible), and 39 aneurysms (81.3%) were grade C or D (near-total occlusion), of which 37 (77.1%) were completely occluded (grade D). Multivariate cox regression analysis revealed that the AneuGuide™ group had a significantly higher complete occlusion rate at follow-up compared to the non-AneuGuide™ group (HR = 2.290, p = 0.044). One patient in the non-AneuGuide™ group developed in-stent stenosis without clinical symptoms. No new neurological deficits were observed in any of the patients during the follow-up period.</p><p><strong>Conclusion: </strong>FD placement for complex intracranial aneurysms assisted by AneuGuide™ software is a safe and effective treatment. Further prospective studies are needed to validate these findings.</p>\",\"PeriodicalId\":23906,\"journal\":{\"name\":\"World neurosurgery\",\"volume\":\" \",\"pages\":\"124501\"},\"PeriodicalIF\":2.1000,\"publicationDate\":\"2025-09-24\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"World neurosurgery\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/j.wneu.2025.124501\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"World neurosurgery","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.wneu.2025.124501","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
引用次数: 0
摘要
目的：探讨AneuGuide™软件引导下血流分流器（FDs）治疗颅内复杂动脉瘤的疗效和安全性。方法：对2019年8月至2023年12月收治的48例颅内复杂动脉瘤患者45例进行回顾性分析。其中21个动脉瘤采用AneuGuide™软件（ArteryFlow Technology, Hangzhou, China）引导下的FDs植入治疗，27个动脉瘤在没有AneuGuide™辅助的情况下接受FDs治疗。比较两组术后立即栓塞率、并发症发生率、临床及影像学随访结果。结果：45例患者48个动脉瘤共植入49个fd，其中10例患者接受了额外的线圈栓塞。无围手术期并发症发生。随访1年，血管造影显示：B级（部分可见）动脉瘤9个（18.8%），C级或D级（近完全闭塞）动脉瘤39个（81.3%），其中完全闭塞37个（77.1%）。多因素cox回归分析显示，AneuGuide™组随访时的完全闭塞率明显高于非AneuGuide™组（HR = 2.290, p = 0.044）。非aneuguide组1例患者出现无临床症状的支架内狭窄。在随访期间，没有观察到任何患者出现新的神经功能缺损。结论：AneuGuide™软件辅助下FD植入治疗复杂颅内动脉瘤是一种安全有效的治疗方法。需要进一步的前瞻性研究来验证这些发现。
Single-Center Experience with AneuGuide™ Software-Assisted Flow Diverter Treatment for Complex Intracranial Aneurysms.
Objective: To investigate the efficacy and safety of flow diverters (FDs) guided by AneuGuide™ software in treating complex intracranial aneurysms.
Methods: A retrospective analysis was conducted on 45 patients diagnosed with 48 complex intracranial aneurysms from August 2019 to December 2023. Among these, 21 aneurysms were treated with FDs implantation guided by AneuGuide™ software (ArteryFlow Technology, Hangzhou, China), and 27 aneurysms received FDs treatment without AneuGuide™ assistance. Immediate post-operative embolization rates, complication incidences, and clinical and imaging follow-up results were compared between the two groups.
Results: A total of 49 FDs were implanted for the 48 aneurysms in the 45 patients, with 10 patients receiving additional coil embolization. No perioperative complications occurred. At 1-year follow-up, angiography showed: 9 aneurysms (18.8%) were grade B (partially visible), and 39 aneurysms (81.3%) were grade C or D (near-total occlusion), of which 37 (77.1%) were completely occluded (grade D). Multivariate cox regression analysis revealed that the AneuGuide™ group had a significantly higher complete occlusion rate at follow-up compared to the non-AneuGuide™ group (HR = 2.290, p = 0.044). One patient in the non-AneuGuide™ group developed in-stent stenosis without clinical symptoms. No new neurological deficits were observed in any of the patients during the follow-up period.
Conclusion: FD placement for complex intracranial aneurysms assisted by AneuGuide™ software is a safe and effective treatment. Further prospective studies are needed to validate these findings.
期刊介绍：
World Neurosurgery has an open access mirror journal World Neurosurgery: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review.
The journal''s mission is to:
-To provide a first-class international forum and a 2-way conduit for dialogue that is relevant to neurosurgeons and providers who care for neurosurgery patients. The categories of the exchanged information include clinical and basic science, as well as global information that provide social, political, educational, economic, cultural or societal insights and knowledge that are of significance and relevance to worldwide neurosurgery patient care.
-To act as a primary intellectual catalyst for the stimulation of creativity, the creation of new knowledge, and the enhancement of quality neurosurgical care worldwide.
-To provide a forum for communication that enriches the lives of all neurosurgeons and their colleagues; and, in so doing, enriches the lives of their patients.
Topics to be addressed in World Neurosurgery include: EDUCATION, ECONOMICS, RESEARCH, POLITICS, HISTORY, CULTURE, CLINICAL SCIENCE, LABORATORY SCIENCE, TECHNOLOGY, OPERATIVE TECHNIQUES, CLINICAL IMAGES, VIDEOS
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
