伊曲康唑和β-葡聚糖(细叶绿胶)对猫皮肤和粘膜孢子菌病的安全性和临床疗效的前瞻性无控制介入研究。

IF 2.3 2区 农林科学 Q2 VETERINARY SCIENCES
André Felipe Pedrazzi Chacon, Anna Barreto Fernandes Figueiredo, Jéssica Sepulveda Boechat, Erica Guerino Reis, Cindy Caroline Dos Santos Honorato, Maria Lopes Corrêa, Sandro Antonio Pereira, Isabella Dib Ferreira Gremião
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引用次数: 0

摘要

巴西是人类和猫孢子丝虫病的流行地区,巴西孢子丝虫是主要病原。目前,很少有有效的抗真菌药物可用于治疗猫的这种真菌病,治疗研究仍然有限。伊曲康唑(ITZ)为一线药物;然而,其有效性是可变的。为了评估ITZ联合β-葡聚糖(Euglena gracilis)在猫孢子虫病中的应用,对29只猫进行了一项前瞻性、无控制的介入研究。21只动物(72.4%)获得临床治愈,中位治疗时间为10周。这些猫大多表现为鼻区病变、鼻黏膜受累和呼吸体征,这些症状通常与治疗效果不佳有关。治疗失败5只(17.2%),失访3只(10.3%)。研究期间没有死亡记录。2只猫出现药物不良反应(adr),占6.9%。这些发现表明,β-葡聚糖可能是治疗猫孢子虫病的一种补充策略,特别是在涉及鼻腔病变和呼吸体征的情况下,也可能有助于预防与传统治疗相关的不良反应。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Prospective Uncontrolled Interventional Study of Itraconazole and β-Glucans (Euglena gracilis) to Assess Safeness and Clinical Effectiveness in Cats with Cutaneous and Mucosal Sporotrichosis.

Brazil is an endemic region for both human and feline sporotrichosis, with Sporothrix brasiliensis being the main etiological agent. Currently, few effective antifungal agents are available for treating this mycosis in cats, and therapeutic studies remain limited. Itraconazole (ITZ) is the first-line drug; however, its effectiveness is variable. To evaluate the use of ITZ combined with β-glucans (Euglena gracilis) in feline sporotrichosis, a prospective, uncontrolled interventional study was conducted in 29 cats. Clinical cure was achieved in 21 animals (72.4%) with a median treatment duration of 10 weeks. Most of these cats presented with nasal region lesions, nasal mucosa involvement, and respiratory signs, which are commonly associated with poor therapeutic outcomes. Treatment failure occurred in 5 animals (17.2%), and 3 (10.3%) were lost to follow-up. No deaths were recorded during the study. Adverse drug reactions (ADRs) were observed in 2 cats (6.9%). These findings suggest that β-glucans may be a complementary strategy in the treatment of feline sporotrichosis, particularly in cases involving nasal lesions and respiratory signs, and may also contribute to the prevention of ADRs associated with conventional therapy.

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来源期刊
Veterinary Sciences
Veterinary Sciences VETERINARY SCIENCES-
CiteScore
2.90
自引率
8.30%
发文量
612
审稿时长
6 weeks
期刊介绍: Veterinary Sciences is an international and interdisciplinary scholarly open access journal. It publishes original that are relevant to any field of veterinary sciences, including prevention, diagnosis and treatment of disease, disorder and injury in animals. This journal covers almost all topics related to animal health and veterinary medicine. Research fields of interest include but are not limited to: anaesthesiology anatomy bacteriology biochemistry cardiology dentistry dermatology embryology endocrinology epidemiology genetics histology immunology microbiology molecular biology mycology neurobiology oncology ophthalmology parasitology pathology pharmacology physiology radiology surgery theriogenology toxicology virology.
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