微藻制造的生物制药及其在“同一个健康”方案中的潜在作用。

IF 14.9 1区工程技术 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Trends in biotechnology Pub Date : 2025-09-25 DOI:10.1016/j.tibtech.2025.08.018

Ileana García-Silva, Sornkanok Vimolmangkang, Sergio Rosales-Mendoza

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引用次数: 0

摘要

生物制药通过提供支持人类和动物健康的预防和治疗解决方案，在“同一个健康”方针中发挥着至关重要的作用。以微藻为基础的生物制药生产平台生产成本低，对两个部门都有利，因此是推进“同一个健康”倡议的一项有希望的战略。在过去的十年中，在基因工程和藻类系统的生物处理方面取得了重大进展；然而，目前还没有一种由微藻制成的供人类使用的生物药物进入市场。这篇综述提供了对这些进展的最新看法，并强调了该领域的未来方向，重点是克服阻碍该技术应用的障碍。

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Microalgae-made biopharmaceuticals and their potential role in the One Health approach.

Biopharmaceuticals play a crucial role in the One Health approach by providing preventive and therapeutic solutions that support both human and animal health. The microalgae-based platform for producing biopharmaceuticals offers low production costs, benefiting both sectors, and thus represents a promising strategy to advance the One Health initiative. Over the past decade, significant progress has been made in genetic engineering and bioprocessing of algal systems; however, no microalgae-made biopharmaceuticals for human use have yet reached the market. This review provides an updated perspective on these advances and highlights future directions for the field, with a focus on overcoming the hurdles that have delayed the application of this technology.

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来源期刊

Trends in biotechnology 工程技术-生物工程与应用微生物

CiteScore

28.60

自引率

1.20%

发文量

198

审稿时长

1 months

期刊介绍： Trends in Biotechnology publishes reviews and perspectives on the applied biological sciences, focusing on useful science applied to, derived from, or inspired by living systems. The major themes that TIBTECH is interested in include: Bioprocessing (biochemical engineering, applied enzymology, industrial biotechnology, biofuels, metabolic engineering) Omics (genome editing, single-cell technologies, bioinformatics, synthetic biology) Materials and devices (bionanotechnology, biomaterials, diagnostics/imaging/detection, soft robotics, biosensors/bioelectronics) Therapeutics (biofabrication, stem cells, tissue engineering and regenerative medicine, antibodies and other protein drugs, drug delivery) Agroenvironment (environmental engineering, bioremediation, genetically modified crops, sustainable development).