新城疫病毒的遗传多样性及其对疫苗研制的意义

IF 2.3 2区 农林科学 Q2 VETERINARY SCIENCES
Olga A Kondakova, Alexey A Agranovsky, Ekaterina M Ryabchevskaya, Elizaveta P Umarova, Dmitriy L Granovskiy, Stepan E Toropov, Ekaterina A Evtushenko, Nikolai A Nikitin, Olga V Karpova
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引用次数: 0

摘要

新城疫病毒(NDV)是一种禽副粘病毒,在家禽中引起高度传染性的新城疫病。在许多发展中国家常见的新城疫爆发,在世界范围内已有一个世纪的记录。家禽,甚至是接种过疫苗的种群,连同野生和共生鸟类,都是新城疫病病毒的宿主。尽管商业新城疫疫苗被广泛使用,但新城疫在接种疫苗的鸡群中频繁爆发,造成巨大的经济损失。商用新城疫疫苗的主要限制是它们与新出现的新城疫毒株的兼容性有限。预计疫苗和疫苗接种技术的进步将减少致病性新城疫毒株的传播,从而减轻家禽生产中的损失。本文综述了与当前和历史新城疫暴发有关的新城疫基因型和菌株,并评估了现有和候选新城疫疫苗,强调了最近的创新和新技术。我们的目标是描述未来调查的关键主题,并提供广泛的数据,以帮助研究人员了解纽卡斯尔病疫苗预防的当前进展和存在的问题。采用先进技术的新一代疫苗的出现可能会大大提高新城疫预防和控制的效果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Genetic Diversity of Newcastle Disease Virus and Its Implications for Vaccine Development.

The Newcastle disease virus (NDV), an avian paramyxovirus, induces the highly contagious Newcastle disease in poultry. Newcastle disease outbreaks, common in many developing countries, have been recorded worldwide for a century. Poultry, even vaccinated stocks, together with wild and synanthropic birds, serve as reservoirs of NDV. Despite the extensive use of commercial NDV vaccines, Newcastle disease outbreaks frequently occur in vaccinated chickens, resulting in great economic losses. The primary limitation of commercial Newcastle disease vaccines is their restricted compatibility with emerging novel NDV strains. The advancement of vaccines and vaccination techniques is anticipated to reduce the propagation of pathogenic NDV strains and consequently alleviate losses in poultry production. This review examines the NDV genotypes and strains implicated in both current and historical Newcastle disease outbreaks, and evaluates existing and candidate NDV vaccines, emphasizing recent innovations and novel techniques. Our aim was to delineate critical subjects for future inquiry and to furnish extensive data that could aid researchers in understanding the current advancements and existing problems in Newcastle disease vaccination prophylactics. The emergence of a new generation of vaccines employing advanced technologies may substantially improve the efficacy of Newcastle disease prevention and control.

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来源期刊
Veterinary Sciences
Veterinary Sciences VETERINARY SCIENCES-
CiteScore
2.90
自引率
8.30%
发文量
612
审稿时长
6 weeks
期刊介绍: Veterinary Sciences is an international and interdisciplinary scholarly open access journal. It publishes original that are relevant to any field of veterinary sciences, including prevention, diagnosis and treatment of disease, disorder and injury in animals. This journal covers almost all topics related to animal health and veterinary medicine. Research fields of interest include but are not limited to: anaesthesiology anatomy bacteriology biochemistry cardiology dentistry dermatology embryology endocrinology epidemiology genetics histology immunology microbiology molecular biology mycology neurobiology oncology ophthalmology parasitology pathology pharmacology physiology radiology surgery theriogenology toxicology virology.
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