Elisa Hernández-Álvarez, Jaime Rojas-Hernández, Lucas F Borkel, Domingo J Quintana-Hernández, Tobías Fernández-Borkel, Luis Alberto Henríquez-Hernández
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Linear regression analyses examined associations between anxiety reduction, administered dose, and owner psychological traits. A significant reduction in separation anxiety scores was observed post-treatment (mean: 11.3 ± 3.0, <i>p</i> = 0.023). Higher 1cp-LSD doses correlated with greater anxiety reduction (B = -1.15, 95% CI = [-2.29, -0.003], <i>p</i> = 0.050). Additionally, higher owner psychoticism scores were associated with smaller improvements in canine anxiety (<i>p</i> = 0.035). Anxiety levels remained low one month after treatment, with significant associations between canine anxiety and the owners' hostility, interpersonal sensitivity, and paranoid ideation. These findings support the potential role of low-dose serotonergic psychedelics in managing canine anxiety and suggest an association between caregiver psychological traits and treatment outcomes. The sustained reduction in anxiety behaviors also suggests a meaningful and lasting improvement in animal welfare. However, significant results should be interpreted cautiously due to the small sample size. 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引用次数: 0
摘要
本研究考察了低剂量LSD前药1cp-LSD对犬焦虑的影响,同时探讨了饲主精神病理对治疗结果的影响。研究人员招募了7只表现出焦虑相关行为的狗,每三天口服2.5、5或10微克的1cp-LSD,持续30天。另外一只狗没有达到焦虑的临床标准,但它的主人认为它焦虑,作为观察病例,它接受了安慰剂(糖精)。在基线、治疗后和治疗停止后一个月,使用有效的量表评估焦虑水平。采用IPIP和SA-45量表对饲主神经质和精神病理维度进行评估。线性回归分析检验了焦虑减少、给药剂量和所有者心理特征之间的关系。治疗后分离焦虑评分显著降低(平均:11.3±3.0,p = 0.023)。较高的1cp-LSD剂量与更大的焦虑减少相关(B = -1.15, 95% CI = [-2.29, -0.003], p = 0.050)。此外,较高的主人精神病得分与犬焦虑的较小改善相关(p = 0.035)。治疗一个月后,焦虑水平仍然很低,狗的焦虑与主人的敌意、人际关系敏感性和偏执观念之间存在显著关联。这些发现支持了低剂量5 -羟色胺类致幻剂在控制犬类焦虑方面的潜在作用,并表明护理者的心理特征与治疗结果之间存在关联。焦虑行为的持续减少也表明动物福利得到了有意义和持久的改善。然而,由于样本量小,重要的结果应谨慎解释。需要进一步的盲法对照研究来验证这些初步观察结果,并评估在兽医行为医学中的更广泛应用。
Preliminary Findings on Low-Dose 1cp-LSD for Canine Anxiety: Exploring the Role of Owner Neuroticism and Psychopathology.
This study investigated the effects of low-dose 1cp-LSD, a prodrug of LSD, on canine anxiety, while exploring the influence of owner psychopathology on treatment outcomes. Seven dogs exhibiting anxiety-related behaviors were recruited and received 2.5, 5, or 10 µg of 1cp-LSD orally every three days for 30 days. One additional dog, which did not meet clinical criteria for anxiety but whose owner perceived it as anxious, received a placebo (saccharin) as an observational case. Anxiety levels were assessed using validated scales at baseline, post-treatment, and one month after treatment cessation. Owners' neuroticism and psychopathological dimensions were evaluated using the IPIP and SA-45 scales. Linear regression analyses examined associations between anxiety reduction, administered dose, and owner psychological traits. A significant reduction in separation anxiety scores was observed post-treatment (mean: 11.3 ± 3.0, p = 0.023). Higher 1cp-LSD doses correlated with greater anxiety reduction (B = -1.15, 95% CI = [-2.29, -0.003], p = 0.050). Additionally, higher owner psychoticism scores were associated with smaller improvements in canine anxiety (p = 0.035). Anxiety levels remained low one month after treatment, with significant associations between canine anxiety and the owners' hostility, interpersonal sensitivity, and paranoid ideation. These findings support the potential role of low-dose serotonergic psychedelics in managing canine anxiety and suggest an association between caregiver psychological traits and treatment outcomes. The sustained reduction in anxiety behaviors also suggests a meaningful and lasting improvement in animal welfare. However, significant results should be interpreted cautiously due to the small sample size. Further blinded, controlled studies are needed to validate these preliminary observations and assess broader applications in veterinary behavioral medicine.
期刊介绍:
Veterinary Sciences is an international and interdisciplinary scholarly open access journal. It publishes original that are relevant to any field of veterinary sciences, including prevention, diagnosis and treatment of disease, disorder and injury in animals. This journal covers almost all topics related to animal health and veterinary medicine. Research fields of interest include but are not limited to: anaesthesiology anatomy bacteriology biochemistry cardiology dentistry dermatology embryology endocrinology epidemiology genetics histology immunology microbiology molecular biology mycology neurobiology oncology ophthalmology parasitology pathology pharmacology physiology radiology surgery theriogenology toxicology virology.