产前邻苯二甲酸盐暴露与儿童特应性症状的关系:儿童性别影响的改变

IF 4.1 3区 环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES
Toxics Pub Date : 2025-09-03 DOI:10.3390/toxics13090749
Khushbu Dharmendra Bhatt, Shachi Mistry, Héctor Lamadrid-Figueroa, Marcela Tamayo-Ortiz, Adriana Mercado-Garcia, Jamil M Lane, Martha M Téllez-Rojo, Robert O Wright, Rosalind J Wright, Guadalupe Estrada-Gutierrez, Kecia N Carroll, Cecilia S Alcala, Maria José Rosa
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引用次数: 0

摘要

背景:特应性皮炎和过敏性鼻炎等全球特应性疾病的增加可能与产前接触邻苯二甲酸盐等内分泌干扰化学物质有关,并具有潜在的性别特异性影响。方法:我们分析了来自墨西哥城PROGRESS出生队列的558对母子。在妊娠第2和第3个月测量母体尿邻苯二甲酸盐代谢物。利用国际儿童哮喘和过敏研究调查对4-6岁和6-8岁的特应性皮炎和过敏性鼻炎症状进行评估。加权分位数和回归(WQS)用于评估性别特异性混合关联。个体性别特异性邻苯二甲酸酯关联检验使用改进的泊松模型,包括产品条款和分层。模型调整了产妇年龄、教育程度、胎次、孕前体重指数和产前烟草暴露。结果:我们发现,在4-6岁(WQS*性别OR: 1.23, 95% CI: 1.00-1.60)和6-8岁(WQS*性别OR: 1.46, 95% CI: 1.01-2.10)时,孕中期邻苯二甲酸盐混合物与当前特应性皮炎症状之间存在儿童性别改变相关性。在男性中,较高的邻苯二甲酸盐浓度与两个年龄段的症状呈正相关(OR: 1.10, 95% CI: 0.92, 1.32; OR: 1.16, 95% CI: 0.92, 1.46),而在女性中呈负相关(OR: 0.87, 95% CI: 0.73, 1.04; OR: 0.79, 95% CI: 0.62, 1.02)。妊娠晚期暴露未发现性别特异性关联。个体代谢物分析也显示,妊娠中期暴露的影响因性别而异。结论:产前暴露于邻苯二甲酸盐与儿童特应性皮炎症状以性别特异性方式相关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Associations Between Prenatal Phthalate Exposure and Atopic Symptoms in Childhood: Effect Modification by Child Sex.

Associations Between Prenatal Phthalate Exposure and Atopic Symptoms in Childhood: Effect Modification by Child Sex.

Associations Between Prenatal Phthalate Exposure and Atopic Symptoms in Childhood: Effect Modification by Child Sex.

Background: The global rise in atopic diseases, like atopic dermatitis and allergic rhinitis, may be linked to prenatal exposure to endocrine-disrupting chemicals like phthalates, with potential sex-specific effects.

Methods: We analyzed 558 mother-child pairs from the PROGRESS birth cohort in Mexico City. Maternal urinary phthalate metabolites were measured during the 2nd and 3rd trimesters. Atopic dermatitis and allergic rhinitis symptoms were assessed at ages 4-6 and 6-8 years using the International Study of Asthma and Allergies in Childhood survey. Weighted Quantile Sum Regression (WQS) was used to assess sex-specific mixture associations. Individual sex-specific phthalate associations were examined using modified Poisson models with inclusion of product terms and stratification. Models were adjusted for maternal age, education, parity, pre-pregnancy body mass index, and prenatal tobacco exposure.

Results: We found that child sex modified associations between the 2nd trimester phthalate mixture and current atopic dermatitis symptoms at both 4-6 years (WQS*sex OR: 1.23, 95% CI: 1.00-1.60) and 6-8 years (WQS*sex OR: 1.46, 95% CI: 1.01-2.10). Among males, higher phthalate concentrations were positively associated with symptoms at both ages (OR: 1.10, 95% CI: 0.92, 1.32; OR: 1.16, 95% CI: 0.92, 1.46), while associations were negative in females (OR: 0.87, 95% CI: 0.73, 1.04; OR: 0.79, 95% CI: 0.62, 1.02). No sex-specific associations were found for 3rd trimester exposures. Individual metabolite analyses also showed effect modification by sex for 2nd trimester exposures.

Conclusions: Prenatal exposure to phthalates is associated with atopic dermatitis symptoms in childhood in a sex-specific manner.

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来源期刊
Toxics
Toxics Chemical Engineering-Chemical Health and Safety
CiteScore
4.50
自引率
10.90%
发文量
681
审稿时长
6 weeks
期刊介绍: Toxics (ISSN 2305-6304) is an international, peer-reviewed, open access journal which provides an advanced forum for studies related to all aspects of toxic chemicals and materials. It publishes reviews, regular research papers, and short communications. Our aim is to encourage scientists to publish their experimental and theoretical results in detail. There is, therefore, no restriction on the maximum length of the papers, although authors should write their papers in a clear and concise way. The full experimental details must be provided so that the results can be reproduced. Electronic files or software regarding the full details of calculations and experimental procedure can be deposited as supplementary material, if it is not possible to publish them along with the text.
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