Khushbu Dharmendra Bhatt, Shachi Mistry, Héctor Lamadrid-Figueroa, Marcela Tamayo-Ortiz, Adriana Mercado-Garcia, Jamil M Lane, Martha M Téllez-Rojo, Robert O Wright, Rosalind J Wright, Guadalupe Estrada-Gutierrez, Kecia N Carroll, Cecilia S Alcala, Maria José Rosa
{"title":"产前邻苯二甲酸盐暴露与儿童特应性症状的关系:儿童性别影响的改变","authors":"Khushbu Dharmendra Bhatt, Shachi Mistry, Héctor Lamadrid-Figueroa, Marcela Tamayo-Ortiz, Adriana Mercado-Garcia, Jamil M Lane, Martha M Téllez-Rojo, Robert O Wright, Rosalind J Wright, Guadalupe Estrada-Gutierrez, Kecia N Carroll, Cecilia S Alcala, Maria José Rosa","doi":"10.3390/toxics13090749","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>The global rise in atopic diseases, like atopic dermatitis and allergic rhinitis, may be linked to prenatal exposure to endocrine-disrupting chemicals like phthalates, with potential sex-specific effects.</p><p><strong>Methods: </strong>We analyzed 558 mother-child pairs from the PROGRESS birth cohort in Mexico City. Maternal urinary phthalate metabolites were measured during the 2nd and 3rd trimesters. Atopic dermatitis and allergic rhinitis symptoms were assessed at ages 4-6 and 6-8 years using the International Study of Asthma and Allergies in Childhood survey. Weighted Quantile Sum Regression (WQS) was used to assess sex-specific mixture associations. Individual sex-specific phthalate associations were examined using modified Poisson models with inclusion of product terms and stratification. Models were adjusted for maternal age, education, parity, pre-pregnancy body mass index, and prenatal tobacco exposure.</p><p><strong>Results: </strong>We found that child sex modified associations between the 2nd trimester phthalate mixture and current atopic dermatitis symptoms at both 4-6 years (WQS*sex OR: 1.23, 95% CI: 1.00-1.60) and 6-8 years (WQS*sex OR: 1.46, 95% CI: 1.01-2.10). Among males, higher phthalate concentrations were positively associated with symptoms at both ages (OR: 1.10, 95% CI: 0.92, 1.32; OR: 1.16, 95% CI: 0.92, 1.46), while associations were negative in females (OR: 0.87, 95% CI: 0.73, 1.04; OR: 0.79, 95% CI: 0.62, 1.02). No sex-specific associations were found for 3rd trimester exposures. Individual metabolite analyses also showed effect modification by sex for 2nd trimester exposures.</p><p><strong>Conclusions: </strong>Prenatal exposure to phthalates is associated with atopic dermatitis symptoms in childhood in a sex-specific manner.</p>","PeriodicalId":23195,"journal":{"name":"Toxics","volume":"13 9","pages":""},"PeriodicalIF":4.1000,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12473533/pdf/","citationCount":"0","resultStr":"{\"title\":\"Associations Between Prenatal Phthalate Exposure and Atopic Symptoms in Childhood: Effect Modification by Child Sex.\",\"authors\":\"Khushbu Dharmendra Bhatt, Shachi Mistry, Héctor Lamadrid-Figueroa, Marcela Tamayo-Ortiz, Adriana Mercado-Garcia, Jamil M Lane, Martha M Téllez-Rojo, Robert O Wright, Rosalind J Wright, Guadalupe Estrada-Gutierrez, Kecia N Carroll, Cecilia S Alcala, Maria José Rosa\",\"doi\":\"10.3390/toxics13090749\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>The global rise in atopic diseases, like atopic dermatitis and allergic rhinitis, may be linked to prenatal exposure to endocrine-disrupting chemicals like phthalates, with potential sex-specific effects.</p><p><strong>Methods: </strong>We analyzed 558 mother-child pairs from the PROGRESS birth cohort in Mexico City. Maternal urinary phthalate metabolites were measured during the 2nd and 3rd trimesters. Atopic dermatitis and allergic rhinitis symptoms were assessed at ages 4-6 and 6-8 years using the International Study of Asthma and Allergies in Childhood survey. Weighted Quantile Sum Regression (WQS) was used to assess sex-specific mixture associations. Individual sex-specific phthalate associations were examined using modified Poisson models with inclusion of product terms and stratification. Models were adjusted for maternal age, education, parity, pre-pregnancy body mass index, and prenatal tobacco exposure.</p><p><strong>Results: </strong>We found that child sex modified associations between the 2nd trimester phthalate mixture and current atopic dermatitis symptoms at both 4-6 years (WQS*sex OR: 1.23, 95% CI: 1.00-1.60) and 6-8 years (WQS*sex OR: 1.46, 95% CI: 1.01-2.10). Among males, higher phthalate concentrations were positively associated with symptoms at both ages (OR: 1.10, 95% CI: 0.92, 1.32; OR: 1.16, 95% CI: 0.92, 1.46), while associations were negative in females (OR: 0.87, 95% CI: 0.73, 1.04; OR: 0.79, 95% CI: 0.62, 1.02). No sex-specific associations were found for 3rd trimester exposures. 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Associations Between Prenatal Phthalate Exposure and Atopic Symptoms in Childhood: Effect Modification by Child Sex.
Background: The global rise in atopic diseases, like atopic dermatitis and allergic rhinitis, may be linked to prenatal exposure to endocrine-disrupting chemicals like phthalates, with potential sex-specific effects.
Methods: We analyzed 558 mother-child pairs from the PROGRESS birth cohort in Mexico City. Maternal urinary phthalate metabolites were measured during the 2nd and 3rd trimesters. Atopic dermatitis and allergic rhinitis symptoms were assessed at ages 4-6 and 6-8 years using the International Study of Asthma and Allergies in Childhood survey. Weighted Quantile Sum Regression (WQS) was used to assess sex-specific mixture associations. Individual sex-specific phthalate associations were examined using modified Poisson models with inclusion of product terms and stratification. Models were adjusted for maternal age, education, parity, pre-pregnancy body mass index, and prenatal tobacco exposure.
Results: We found that child sex modified associations between the 2nd trimester phthalate mixture and current atopic dermatitis symptoms at both 4-6 years (WQS*sex OR: 1.23, 95% CI: 1.00-1.60) and 6-8 years (WQS*sex OR: 1.46, 95% CI: 1.01-2.10). Among males, higher phthalate concentrations were positively associated with symptoms at both ages (OR: 1.10, 95% CI: 0.92, 1.32; OR: 1.16, 95% CI: 0.92, 1.46), while associations were negative in females (OR: 0.87, 95% CI: 0.73, 1.04; OR: 0.79, 95% CI: 0.62, 1.02). No sex-specific associations were found for 3rd trimester exposures. Individual metabolite analyses also showed effect modification by sex for 2nd trimester exposures.
Conclusions: Prenatal exposure to phthalates is associated with atopic dermatitis symptoms in childhood in a sex-specific manner.
ToxicsChemical Engineering-Chemical Health and Safety
CiteScore
4.50
自引率
10.90%
发文量
681
审稿时长
6 weeks
期刊介绍:
Toxics (ISSN 2305-6304) is an international, peer-reviewed, open access journal which provides an advanced forum for studies related to all aspects of toxic chemicals and materials. It publishes reviews, regular research papers, and short communications. Our aim is to encourage scientists to publish their experimental and theoretical results in detail. There is, therefore, no restriction on the maximum length of the papers, although authors should write their papers in a clear and concise way. The full experimental details must be provided so that the results can be reproduced. Electronic files or software regarding the full details of calculations and experimental procedure can be deposited as supplementary material, if it is not possible to publish them along with the text.