Majid Janani, Amirhoushang Poorkhani, Mirmohammadhosseinaali Sharifiandavaei, Zahra Akbari, Khalil Pourkhalili, Saeed Golfiroozi, Taghi Amiriani, Arash Tahmasebifar, Farahnazsadat Ahmadi, Yalda Jorjanisorkhankalateh, Morad Roudbaraki, Vahid Khori, Ali Mohammad Alizadeh
{"title":"预测成纤维细胞活化蛋白过表达对癌症患者总体生存率的影响：一项系统综述和荟萃分析。","authors":"Majid Janani, Amirhoushang Poorkhani, Mirmohammadhosseinaali Sharifiandavaei, Zahra Akbari, Khalil Pourkhalili, Saeed Golfiroozi, Taghi Amiriani, Arash Tahmasebifar, Farahnazsadat Ahmadi, Yalda Jorjanisorkhankalateh, Morad Roudbaraki, Vahid Khori, Ali Mohammad Alizadeh","doi":"10.1186/s13643-025-02929-6","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Fibroblast activation protein-alpha (FAP-α) is a vital surface marker of cancer-associated fibroblasts, and its high expression is associated with distant metastasis. This systematic review and meta-analysis were performed to predict the role of FAP-α overexpression in the overall survival rate of cancer patients.</p><p><strong>Methods: </strong>This systematic review and meta-analysis were first performed on studies published in online databases, including PubMed, Scopus, and Web of Sciences, based on the PRISMA framework. We focused on all cancer patients with reported FAP-α expression levels and survival rate outcomes. Two reviewers independently conducted study selection and data extraction, and discrepancies were resolved through group discussion. Pooled hazard ratios (HRs) were then calculated by the fixed-effect and random-effects models to determine the association between FAP-α with crude HR (univariable), adjusted HR (multivariable), progression-free survival, and disease-free survival.</p><p><strong>Results: </strong>Forty-one studies were included in the systematic review, and 25 were included in the meta-analysis. Meta-analysis showed that high FAP-α expression was associated with the pooled HR for overall survival (HR = 1.49, 95% CI: 1.19-1.85, P < 0.001) and HR of 1.53 in studies that reported the adjusted effect of high FAP-α expression on overall survival (HR = 1.53, 95% CI: 1.16-2.03, P = 0.003), and HR of 1.36 for disease-free survival (HR = 1.36, 95% CI: 0.750-2.469, P = 0.31). In addition, lymph node metastasis and distant metastasis were significant factors and had pooled HRs of 2.053 (95% CI: 1.603-2.630, P < 0.001) and 2.630 (95% CI: 1.902-3.637, P < 0.001), respectively.</p><p><strong>Conclusions: </strong>Our results showed that cancer patients with FAP-α overexpression had a significant association with poor overall survival. 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Meta-analysis showed that high FAP-α expression was associated with the pooled HR for overall survival (HR = 1.49, 95% CI: 1.19-1.85, P < 0.001) and HR of 1.53 in studies that reported the adjusted effect of high FAP-α expression on overall survival (HR = 1.53, 95% CI: 1.16-2.03, P = 0.003), and HR of 1.36 for disease-free survival (HR = 1.36, 95% CI: 0.750-2.469, P = 0.31). In addition, lymph node metastasis and distant metastasis were significant factors and had pooled HRs of 2.053 (95% CI: 1.603-2.630, P < 0.001) and 2.630 (95% CI: 1.902-3.637, P < 0.001), respectively.</p><p><strong>Conclusions: </strong>Our results showed that cancer patients with FAP-α overexpression had a significant association with poor overall survival. 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引用次数: 0
摘要
成纤维细胞活化蛋白α (FAP-α)是癌症相关成纤维细胞的重要表面标志物，其高表达与远处转移有关。本研究通过系统回顾和荟萃分析来预测FAP-α过表达在癌症患者总生存率中的作用。方法：本系统综述和荟萃分析首先在基于PRISMA框架的在线数据库中发表，包括PubMed、Scopus和Web of Sciences。我们关注的是所有报告了FAP-α表达水平和生存率结果的癌症患者。两位审稿人独立进行研究选择和数据提取，通过小组讨论解决差异。然后通过固定效应和随机效应模型计算合并风险比（HR），以确定FAP-α与粗HR（单变量）、调整HR（多变量）、无进展生存期和无病生存期之间的关系。结果：41项研究被纳入系统评价，25项研究被纳入meta分析。荟萃分析显示，FAP-α高表达与总生存率的合并HR相关（HR = 1.49, 95% CI: 1.19-1.85， P）。结论：我们的研究结果显示，FAP-α过表达的癌症患者与总生存率差有显著相关。将FAP-α检测纳入癌症诊断方案可以帮助识别需要更多关键治疗干预的高危患者。
Predicting fibroblast activation protein overexpression in the overall survival rate of cancer patients: a systematic review and meta-analysis.
Introduction: Fibroblast activation protein-alpha (FAP-α) is a vital surface marker of cancer-associated fibroblasts, and its high expression is associated with distant metastasis. This systematic review and meta-analysis were performed to predict the role of FAP-α overexpression in the overall survival rate of cancer patients.
Methods: This systematic review and meta-analysis were first performed on studies published in online databases, including PubMed, Scopus, and Web of Sciences, based on the PRISMA framework. We focused on all cancer patients with reported FAP-α expression levels and survival rate outcomes. Two reviewers independently conducted study selection and data extraction, and discrepancies were resolved through group discussion. Pooled hazard ratios (HRs) were then calculated by the fixed-effect and random-effects models to determine the association between FAP-α with crude HR (univariable), adjusted HR (multivariable), progression-free survival, and disease-free survival.
Results: Forty-one studies were included in the systematic review, and 25 were included in the meta-analysis. Meta-analysis showed that high FAP-α expression was associated with the pooled HR for overall survival (HR = 1.49, 95% CI: 1.19-1.85, P < 0.001) and HR of 1.53 in studies that reported the adjusted effect of high FAP-α expression on overall survival (HR = 1.53, 95% CI: 1.16-2.03, P = 0.003), and HR of 1.36 for disease-free survival (HR = 1.36, 95% CI: 0.750-2.469, P = 0.31). In addition, lymph node metastasis and distant metastasis were significant factors and had pooled HRs of 2.053 (95% CI: 1.603-2.630, P < 0.001) and 2.630 (95% CI: 1.902-3.637, P < 0.001), respectively.
Conclusions: Our results showed that cancer patients with FAP-α overexpression had a significant association with poor overall survival. Incorporating FAP-α testing into cancer diagnostic protocols can help identify high-risk patients requiring more critical treatment interventions.
期刊介绍：
Systematic Reviews encompasses all aspects of the design, conduct and reporting of systematic reviews. The journal publishes high quality systematic review products including systematic review protocols, systematic reviews related to a very broad definition of health, rapid reviews, updates of already completed systematic reviews, and methods research related to the science of systematic reviews, such as decision modelling. At this time Systematic Reviews does not accept reviews of in vitro studies. The journal also aims to ensure that the results of all well-conducted systematic reviews are published, regardless of their outcome.
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