Julia Loureiro Sion, Daniele M. Celeste, Bernadete L. Liphaus, Marlene P. Garanito, Jorge D. A. Carneiro
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Cerebral Sinovenous Thrombosis: 20 Years of Experience in a Pediatric Tertiary Center
Cerebral sinovenous thrombosis (CSVT) is rare in children and is related to risk factors, as dehydration and infections. This study analyzed 44 pediatric cases of CSVT from a 20-year registry. Risk factors were identified in 93%, infection being the most frequent. Thrombophilia was detected in eight patients. Most patients (91%) received anticoagulation: 78% low molecular weight heparin and 20% unfractionated heparin. Treatment duration exceeded current recommendations (median 21 weeks), as most cases were treated based on CHEST 2012 guidelines. One patient experienced major bleeding related to anticoagulation. All thrombi improved, with 49% achieving complete resolution. There were no recurrences and no fatalities linked to anticoagulation.
期刊介绍：
Pediatric Blood & Cancer publishes the highest quality manuscripts describing basic and clinical investigations of blood disorders and malignant diseases of childhood including diagnosis, treatment, epidemiology, etiology, biology, and molecular and clinical genetics of these diseases as they affect children, adolescents, and young adults. Pediatric Blood & Cancer will also include studies on such treatment options as hematopoietic stem cell transplantation, immunology, and gene therapy.
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