平衡宿主防御和病毒耐受性以开发下一代广谱抗病毒药物。

IF 3.3 3区医学 Q2 MICROBIOLOGY

Pathogens Pub Date : 2025-09-10 DOI:10.3390/pathogens14090911

Xiujuan Zhao, Ruikun Du, Lijun Rong

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引用次数: 0

摘要

人类免疫系统已经进化到使用两种主要策略来应对各种病毒感染：宿主防御和病毒耐受。宿主防御依靠先天免疫和适应性免疫反应来控制病毒复制，而病毒耐受性允许病毒在宿主体内充分复制，且很少或没有临床症状。一般来说，平衡的宿主防御和病毒耐受性可以保证健康免受感染，而破坏免疫稳态通常会导致疾病。开发药物/治疗方法来增强宿主免疫平衡的抗病毒性是很有必要的。本文综述了宿主对病毒感染的防御和耐受机制，以及通过调节宿主防御和耐受之间的平衡而起作用的治疗药物/方法的最新进展。

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Balancing Host Defense and Viral Tolerance for the Development of Next-Generation Broad-Spectrum Antiviral Agents.

The human immune system has evolved to cope with various virus infections using two major strategies: host defense and viral tolerance. The host defense relies on the innate and adaptive immune responses to control virus replication, while the viral tolerance allows sufficient virus replication in the host with minimal or no clinical signs. Generally, a balanced host defense and viral tolerance can guarantee health from infections, while disturbed immune homeostasis usually results in diseases. It is desirable to develop drugs/therapeutics to enhance the invulnerability of host immune equilibrium to combat viral infections. In this review, we summarize the advanced understanding on mechanisms of both the host defense against and tolerance to virus infections, and therapeutic agents/approaches that work by modulating the balance between host defense and tolerance.

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来源期刊

Pathogens Medicine-Immunology and Allergy

CiteScore

6.40

自引率

8.10%

发文量

1285

审稿时长

17.75 days

期刊介绍： Pathogens (ISSN 2076-0817) publishes reviews, regular research papers and short notes on all aspects of pathogens and pathogen-host interactions. There is no restriction on the length of the papers. Our aim is to encourage scientists to publish their experimental and theoretical research in as much detail as possible. Full experimental and/or methodical details must be provided for research articles.