{"title":"韩国成年人维生素D代谢物与肥胖和肌肉相关表型的差异关联：来自KNHANES 2022-2023的结果","authors":"Se-Hong Kim, Yuji Jeong, Seok-Won Son, Ha-Na Kim","doi":"10.3390/nu17183013","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Body composition plays a crucial role in metabolic health, aging, and the development of various diseases. Vitamin D has been implicated in the regulation of muscle and adipose tissue function, but its relationship with body composition remains unclear.</p><p><strong>Objectives: </strong>This study aimed to investigate the association between serum 25-hydroxyvitamin D (25[OH]D) concentration, its subspecies, and body composition parameters and related phenotypes in Korean adults aged ≥20 years.</p><p><strong>Methods: </strong>This cross-sectional study included 2612 eligible participants from the Korea National Health and Nutrition Examination Survey 2022-2023, and data on body composition parameters and serum 25(OH)D levels were analyzed. Serum 25(OH)D levels and subspecies were determined using liquid chromatography-tandem mass spectrometry. Body composition factors included anthropometric indices, muscle strength, and fat and muscle mass, which were assessed using bioelectrical impedance analysis.</p><p><strong>Results: </strong>After multivariable adjustment, serum concentrations of total 25(OH)D and 25(OH)D<sub>3</sub> were inversely associated with waist circumference, body mass index, and fat mass and positively associated with handgrip strength and lean mass, whereas serum 25(OH)D<sub>2</sub> and 3-epi-25(OH)D<sub>3</sub> levels showed no such associations. Higher 25(OH)D<sub>2</sub> concentrations were positively associated with low muscle strength and the prevalence of sarcopenia. Through non-linear analyses, U-shaped correlations were identified between total 25(OH)D and 25(OH)D<sub>3</sub> levels with low muscle mass, respectively, while a J-shaped correlation was observed between 25(OH)D<sub>2</sub> level and low muscle mass.</p><p><strong>Conclusions: </strong>Total 25(OH)D and 25(OH)D<sub>3</sub> levels were inversely associated with adiposity and positively associated with muscle strength and lean mass, whereas the 25(OH)D<sub>2</sub> level was linked to low muscle strength and sarcopenia. The U- and J-shaped associations with low muscle mass indicate the complex and differential roles of vitamin D subspecies, warranting further study.</p>","PeriodicalId":19486,"journal":{"name":"Nutrients","volume":"17 18","pages":""},"PeriodicalIF":5.0000,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12472871/pdf/","citationCount":"0","resultStr":"{\"title\":\"Differential Associations of Vitamin D Metabolites with Adiposity and Muscle-Related Phenotypes in Korean Adults: Results from KNHANES 2022-2023.\",\"authors\":\"Se-Hong Kim, Yuji Jeong, Seok-Won Son, Ha-Na Kim\",\"doi\":\"10.3390/nu17183013\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Body composition plays a crucial role in metabolic health, aging, and the development of various diseases. Vitamin D has been implicated in the regulation of muscle and adipose tissue function, but its relationship with body composition remains unclear.</p><p><strong>Objectives: </strong>This study aimed to investigate the association between serum 25-hydroxyvitamin D (25[OH]D) concentration, its subspecies, and body composition parameters and related phenotypes in Korean adults aged ≥20 years.</p><p><strong>Methods: </strong>This cross-sectional study included 2612 eligible participants from the Korea National Health and Nutrition Examination Survey 2022-2023, and data on body composition parameters and serum 25(OH)D levels were analyzed. Serum 25(OH)D levels and subspecies were determined using liquid chromatography-tandem mass spectrometry. Body composition factors included anthropometric indices, muscle strength, and fat and muscle mass, which were assessed using bioelectrical impedance analysis.</p><p><strong>Results: </strong>After multivariable adjustment, serum concentrations of total 25(OH)D and 25(OH)D<sub>3</sub> were inversely associated with waist circumference, body mass index, and fat mass and positively associated with handgrip strength and lean mass, whereas serum 25(OH)D<sub>2</sub> and 3-epi-25(OH)D<sub>3</sub> levels showed no such associations. Higher 25(OH)D<sub>2</sub> concentrations were positively associated with low muscle strength and the prevalence of sarcopenia. Through non-linear analyses, U-shaped correlations were identified between total 25(OH)D and 25(OH)D<sub>3</sub> levels with low muscle mass, respectively, while a J-shaped correlation was observed between 25(OH)D<sub>2</sub> level and low muscle mass.</p><p><strong>Conclusions: </strong>Total 25(OH)D and 25(OH)D<sub>3</sub> levels were inversely associated with adiposity and positively associated with muscle strength and lean mass, whereas the 25(OH)D<sub>2</sub> level was linked to low muscle strength and sarcopenia. The U- and J-shaped associations with low muscle mass indicate the complex and differential roles of vitamin D subspecies, warranting further study.</p>\",\"PeriodicalId\":19486,\"journal\":{\"name\":\"Nutrients\",\"volume\":\"17 18\",\"pages\":\"\"},\"PeriodicalIF\":5.0000,\"publicationDate\":\"2025-09-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12472871/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nutrients\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.3390/nu17183013\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"NUTRITION & DIETETICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nutrients","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3390/nu17183013","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"NUTRITION & DIETETICS","Score":null,"Total":0}
Differential Associations of Vitamin D Metabolites with Adiposity and Muscle-Related Phenotypes in Korean Adults: Results from KNHANES 2022-2023.
Background: Body composition plays a crucial role in metabolic health, aging, and the development of various diseases. Vitamin D has been implicated in the regulation of muscle and adipose tissue function, but its relationship with body composition remains unclear.
Objectives: This study aimed to investigate the association between serum 25-hydroxyvitamin D (25[OH]D) concentration, its subspecies, and body composition parameters and related phenotypes in Korean adults aged ≥20 years.
Methods: This cross-sectional study included 2612 eligible participants from the Korea National Health and Nutrition Examination Survey 2022-2023, and data on body composition parameters and serum 25(OH)D levels were analyzed. Serum 25(OH)D levels and subspecies were determined using liquid chromatography-tandem mass spectrometry. Body composition factors included anthropometric indices, muscle strength, and fat and muscle mass, which were assessed using bioelectrical impedance analysis.
Results: After multivariable adjustment, serum concentrations of total 25(OH)D and 25(OH)D3 were inversely associated with waist circumference, body mass index, and fat mass and positively associated with handgrip strength and lean mass, whereas serum 25(OH)D2 and 3-epi-25(OH)D3 levels showed no such associations. Higher 25(OH)D2 concentrations were positively associated with low muscle strength and the prevalence of sarcopenia. Through non-linear analyses, U-shaped correlations were identified between total 25(OH)D and 25(OH)D3 levels with low muscle mass, respectively, while a J-shaped correlation was observed between 25(OH)D2 level and low muscle mass.
Conclusions: Total 25(OH)D and 25(OH)D3 levels were inversely associated with adiposity and positively associated with muscle strength and lean mass, whereas the 25(OH)D2 level was linked to low muscle strength and sarcopenia. The U- and J-shaped associations with low muscle mass indicate the complex and differential roles of vitamin D subspecies, warranting further study.
期刊介绍：
Nutrients (ISSN 2072-6643) is an international, peer-reviewed open access advanced forum for studies related to Human Nutrition. It publishes reviews, regular research papers and short communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced.
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