Synthesis and Characterization of Curcumin-Polycaprolactone Block Copolymers for Biomedical Applications.

Polycaprolactone (PCL) is widely utilized in biomedical applications such as tissue engineering and drug delivery; however, its limited bioactivity remains a key challenge. In this study, bioactive curcumin-polycaprolactone block copolymers (MCP) were synthesized via ring-opening polymerization of ε-caprolactone and maleic anhydride modified curcumin. The resulting MCP was characterized using FTIR, ¹H NMR, UV-Vis spectroscopy, and differential scanning calorimetry (DSC). It demonstrated enhanced antioxidant activity, UV-blocking capacity, and electro spinnability compared to PCL. Electrospun MCP films exhibited improved biocompatibility and promoted fibroblast migration. Furthermore, composite films incorporating MCP into a PVA matrix with and without copper or iron were evaluated for in vivo toxicity and antimicrobial activity. These formulations showed no systemic or contact toxicity in the Galleria mellonella model, confirming their biocompatibility. Films containing copper or iron exhibited selective anti-Pseudomonas aeruginosa activity and low but reproducible antioxidant capacity. This study highlights the multifunctionality and biomedical potential of MCP and its composites as tunable platforms for regenerative and antimicrobial applications.