{"title":"超声介导脑内给药研究进展。","authors":"Yinxu Wang, Qian Wen, Anli Hu, Xin Chen, Jingjing Liu, Jingyi Lin, Yulei Xie","doi":"10.1093/jpp/rgaf090","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>The primary objective of this review is to summarize research cases and recent advances in ultrasound technology for overcoming the blood-brain barrier (BBB) and facilitating drug delivery to the brain, thereby providing insights to promote research on enhancing drug permeation across the BBB.</p><p><strong>Key findings: </strong>This review summarizes recent advances in focused ultrasound combined with microbubbles to enhance BBB permeability for brain-targeted drug delivery. It covers the mechanisms by which ultrasound and microbubbles open the BBB, the factors influencing this process, and their applications in brain diseases. Finally, existing challenges in the field are highlighted, and the prospects for clinical translation are discussed.</p><p><strong>Summary: </strong>Ultrasound combined with microbubble technology can safely, non-invasively, and reversibly open the BBB and deliver drugs, offering novel strategies and methods for the treatment of brain diseases.</p>","PeriodicalId":16960,"journal":{"name":"Journal of Pharmacy and Pharmacology","volume":" ","pages":""},"PeriodicalIF":3.2000,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Advances in ultrasound-mediated brain drug delivery.\",\"authors\":\"Yinxu Wang, Qian Wen, Anli Hu, Xin Chen, Jingjing Liu, Jingyi Lin, Yulei Xie\",\"doi\":\"10.1093/jpp/rgaf090\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objectives: </strong>The primary objective of this review is to summarize research cases and recent advances in ultrasound technology for overcoming the blood-brain barrier (BBB) and facilitating drug delivery to the brain, thereby providing insights to promote research on enhancing drug permeation across the BBB.</p><p><strong>Key findings: </strong>This review summarizes recent advances in focused ultrasound combined with microbubbles to enhance BBB permeability for brain-targeted drug delivery. It covers the mechanisms by which ultrasound and microbubbles open the BBB, the factors influencing this process, and their applications in brain diseases. Finally, existing challenges in the field are highlighted, and the prospects for clinical translation are discussed.</p><p><strong>Summary: </strong>Ultrasound combined with microbubble technology can safely, non-invasively, and reversibly open the BBB and deliver drugs, offering novel strategies and methods for the treatment of brain diseases.</p>\",\"PeriodicalId\":16960,\"journal\":{\"name\":\"Journal of Pharmacy and Pharmacology\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":3.2000,\"publicationDate\":\"2025-09-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Pharmacy and Pharmacology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1093/jpp/rgaf090\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"PHARMACOLOGY & PHARMACY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Pharmacy and Pharmacology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1093/jpp/rgaf090","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
Advances in ultrasound-mediated brain drug delivery.
Objectives: The primary objective of this review is to summarize research cases and recent advances in ultrasound technology for overcoming the blood-brain barrier (BBB) and facilitating drug delivery to the brain, thereby providing insights to promote research on enhancing drug permeation across the BBB.
Key findings: This review summarizes recent advances in focused ultrasound combined with microbubbles to enhance BBB permeability for brain-targeted drug delivery. It covers the mechanisms by which ultrasound and microbubbles open the BBB, the factors influencing this process, and their applications in brain diseases. Finally, existing challenges in the field are highlighted, and the prospects for clinical translation are discussed.
Summary: Ultrasound combined with microbubble technology can safely, non-invasively, and reversibly open the BBB and deliver drugs, offering novel strategies and methods for the treatment of brain diseases.
期刊介绍：
JPP keeps pace with new research on how drug action may be optimized by new technologies, and attention is given to understanding and improving drug interactions in the body. At the same time, the journal maintains its established and well-respected core strengths in areas such as pharmaceutics and drug delivery, experimental and clinical pharmacology, biopharmaceutics and drug disposition, and drugs from natural sources. JPP publishes at least one special issue on a topical theme each year.
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