{"title":"出血性脑血管意外患者血清miRNA-124的表达及其临床意义","authors":"Kai-Li Liu, He Wang","doi":"10.1186/s40001-025-03152-8","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to examine serum miRNA-124 expression in patients diagnosed with hemorrhagic cerebrovascular accident (CVA) and evaluate its clinical significance.</p><p><strong>Methods: </strong>A prospective observational study was conducted involving 20 patients diagnosed with hemorrhagic CVA who were admitted to the Department of Neurosurgery, Affiliated Hospital of Beihua University. Quantitative reverse transcription polymerase chain reaction was used to measure serum miRNA-124 levels within 12 h of symptom onset and on day 7 after onset.</p><p><strong>Results: </strong>Paired t test analysis yielded a test statistic of t = 3.499 (p = 0.002), indicating a statistically significant difference between the two timepoints. Serum miRNA-124 levels on day 7 were significantly higher than within 12 h of onset, possibly reflecting the progression of post-hemorrhagic cerebral edema.</p><p><strong>Conclusions: </strong>Serum miRNA-124 expression in patients diagnosed with hemorrhagic CVA was significantly higher on day 7 after onset than within 12 h. This finding aligns with previous reports suggesting a potential relationship between miRNA-124 upregulation and the development of cerebral edema after hemorrhagic CVA.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":"30 1","pages":"870"},"PeriodicalIF":3.4000,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12465184/pdf/","citationCount":"0","resultStr":"{\"title\":\"Serum miRNA-124 expression in patients diagnosed with hemorrhagic cerebrovascular accident and its clinical significance.\",\"authors\":\"Kai-Li Liu, He Wang\",\"doi\":\"10.1186/s40001-025-03152-8\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objectives: </strong>This study aimed to examine serum miRNA-124 expression in patients diagnosed with hemorrhagic cerebrovascular accident (CVA) and evaluate its clinical significance.</p><p><strong>Methods: </strong>A prospective observational study was conducted involving 20 patients diagnosed with hemorrhagic CVA who were admitted to the Department of Neurosurgery, Affiliated Hospital of Beihua University. Quantitative reverse transcription polymerase chain reaction was used to measure serum miRNA-124 levels within 12 h of symptom onset and on day 7 after onset.</p><p><strong>Results: </strong>Paired t test analysis yielded a test statistic of t = 3.499 (p = 0.002), indicating a statistically significant difference between the two timepoints. Serum miRNA-124 levels on day 7 were significantly higher than within 12 h of onset, possibly reflecting the progression of post-hemorrhagic cerebral edema.</p><p><strong>Conclusions: </strong>Serum miRNA-124 expression in patients diagnosed with hemorrhagic CVA was significantly higher on day 7 after onset than within 12 h. This finding aligns with previous reports suggesting a potential relationship between miRNA-124 upregulation and the development of cerebral edema after hemorrhagic CVA.</p>\",\"PeriodicalId\":11949,\"journal\":{\"name\":\"European Journal of Medical Research\",\"volume\":\"30 1\",\"pages\":\"870\"},\"PeriodicalIF\":3.4000,\"publicationDate\":\"2025-09-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12465184/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"European Journal of Medical Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1186/s40001-025-03152-8\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"MEDICINE, RESEARCH & EXPERIMENTAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Journal of Medical Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s40001-025-03152-8","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}
Serum miRNA-124 expression in patients diagnosed with hemorrhagic cerebrovascular accident and its clinical significance.
Objectives: This study aimed to examine serum miRNA-124 expression in patients diagnosed with hemorrhagic cerebrovascular accident (CVA) and evaluate its clinical significance.
Methods: A prospective observational study was conducted involving 20 patients diagnosed with hemorrhagic CVA who were admitted to the Department of Neurosurgery, Affiliated Hospital of Beihua University. Quantitative reverse transcription polymerase chain reaction was used to measure serum miRNA-124 levels within 12 h of symptom onset and on day 7 after onset.
Results: Paired t test analysis yielded a test statistic of t = 3.499 (p = 0.002), indicating a statistically significant difference between the two timepoints. Serum miRNA-124 levels on day 7 were significantly higher than within 12 h of onset, possibly reflecting the progression of post-hemorrhagic cerebral edema.
Conclusions: Serum miRNA-124 expression in patients diagnosed with hemorrhagic CVA was significantly higher on day 7 after onset than within 12 h. This finding aligns with previous reports suggesting a potential relationship between miRNA-124 upregulation and the development of cerebral edema after hemorrhagic CVA.
期刊介绍：
European Journal of Medical Research publishes translational and clinical research of international interest across all medical disciplines, enabling clinicians and other researchers to learn about developments and innovations within these disciplines and across the boundaries between disciplines. The journal publishes high quality research and reviews and aims to ensure that the results of all well-conducted research are published, regardless of their outcome.
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