卡波西肉瘤最新进展

IF 2.2 4区医学 Q2 DERMATOLOGY

Clinics in dermatology Pub Date : 2026-01-01 Epub Date: 2025-09-24 DOI:10.1016/j.clindermatol.2025.09.013

Kyaw Zin Htet BA , Eman Bahrani MD , Kieron S. Leslie MB, BS, FRCP

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引用次数: 0

摘要

卡波西肉瘤（KS）是一种血管增生性肿瘤，与人类疱疹病毒8 （HHV-8）或卡波西肉瘤相关疱疹病毒（KSHV）感染有关。KS通常在皮肤上表现为孤立或多发的紫色斑疹或丘疹样病变或斑块。典型性KS、地方性KS、流行或艾滋病相关KS和医源性KS这四种不同的临床类型在流行病学、表现和并发症方面具有异质性。本文综述了各种类型KS的临床特点、诊断方式和治疗方案。对于临床医生来说，及时认识到并以多学科的方式治疗KS是很重要的，以获得最佳的治疗结果。基于其发病机制的新的靶向治疗正在研究中。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Updates on Kaposi sarcoma

Kaposi sarcoma (KS) is an angioproliferative tumor that is associated with human herpesvirus 8 or Kaposi sarcoma-associated herpes virus infection. KS typically presents in the skin as isolated or multiple, violaceous macules or papulonodular lesions or plaques. The four different KS clinical categories—classic, endemic, epidemic, or AIDS-related and iatrogenic KS—are heterogeneous in epidemiology, manifestations, and complications. Clinical features, diagnostic modalities, and therapeutic regimens for all types of KS are summarized in this review. It is important for clinicians to promptly recognize and approach the treatment of KS in a multidisciplinary fashion for optimal therapeutic outcomes. Newer targeted therapies based on its pathogenesis are being studied.

Kaposi sarcoma (KS) is a vascular tumor associated with human herpesvirus 8 (HHV-8), also known as Kaposi sarcoma-associated herpesvirus (KSHV) infection. KS was first documented in 1872 by Moritz Kaposi, (1837-1902) a Hungarian dermatologist and physician, who described five cases of an atypical tumor that primarily affected the skin of the lower extremities of elderly men.¹ He described the tumors as “idiopathic multiple pigmented sarcoma of the skin,” and this form of the disease later became known as sporadic or classic KS.¹

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来源期刊

Clinics in dermatology 医学-皮肤病学

CiteScore

4.60

自引率

7.40%

发文量

106

审稿时长

3 days

期刊介绍： Clinics in Dermatology brings you the most practical and comprehensive information on the treatment and care of skin disorders. Each issue features a Guest Editor and is devoted to a single timely topic relating to clinical dermatology. Clinics in Dermatology provides information that is... • Clinically oriented -- from evaluation to treatment, Clinics in Dermatology covers what is most relevant to you in your practice. • Authoritative -- world-renowned experts in the field assure the high-quality and currency of each issue by reporting on their areas of expertise. • Well-illustrated -- each issue is complete with photos, drawings and diagrams to illustrate points and demonstrate techniques.