Yingyi Wu, Zheng Qu, Ting Yang, Shan Yao, Jie Chen, Xinye Bao, Ting Yin, Bin Song, Zheng Ye
{"title":"使用单指数、体素内非相干运动和扩散峰度模型的同时多层扩散加权成像的性能:评估肝细胞癌微血管侵袭和组织学分级。","authors":"Yingyi Wu, Zheng Qu, Ting Yang, Shan Yao, Jie Chen, Xinye Bao, Ting Yin, Bin Song, Zheng Ye","doi":"10.1186/s40644-025-00930-9","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to evaluate the diagnostic performance of simultaneous multislice (SMS) acquisition combined with monoexponential, intravoxel incoherent motion (IVIM), and diffusion kurtosis imaging (DKI) models for predicting microvascular invasion (MVI) and histologic grade in hepatocellular carcinoma (HCC).</p><p><strong>Materials and methods: </strong>A prospective study was conducted with 77 HCC patients. Diffusion-weighted imaging (DWI), IVIM, and DKI were performed on a 3T MRI using both SMS and conventional sequences. The values of diffusion parameters (ADC, D, D*, f, MD, and MK) were compared among SMS and conventional sequences, between MVI-positive and MVI-negative groups, and between high-grade and low-grade HCC groups. Receiver operating characteristic (ROC) curves were used to assess the diagnostic performance of diffusion parameters in predicting MVI and histologic grade. Inter-reader consistency was evaluated using intraclass correlation coefficients (ICC).</p><p><strong>Results: </strong>Among the 77 patients, 29.9% were MVI-positive and 35.1% had high-grade HCC. SMS reduced scanning time by up to 44.44%. Most diffusion parameters were similar between SMS and conventional sequences, except for slightly lower ADC and f in SMS. MVI-positive and high-grade HCC cases showed lower ADC, D, D*, and MD values and higher MK values. The ICC ranged from 0.702 to 0.879. SMS-MK demonstrated the highest diagnostic performance with an AUC of 0.92 for MVI and 0.86 for histologic grade.</p><p><strong>Conclusions: </strong>SMS acquisition, integrated with IVIM and DKI, is a feasible imaging method for preoperative evaluation of MVI and histologic grade in HCC, offering a faster alternative to conventional methods without compromising diagnostic performance.</p>","PeriodicalId":9548,"journal":{"name":"Cancer Imaging","volume":"25 1","pages":"113"},"PeriodicalIF":3.5000,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12465415/pdf/","citationCount":"0","resultStr":"{\"title\":\"Performance of simultaneous multislice diffusion-weighted imaging using monoexponential, intravoxel incoherent motion, and diffusion kurtosis models: assessment of microvascular invasion and histologic grade in hepatocellular carcinoma.\",\"authors\":\"Yingyi Wu, Zheng Qu, Ting Yang, Shan Yao, Jie Chen, Xinye Bao, Ting Yin, Bin Song, Zheng Ye\",\"doi\":\"10.1186/s40644-025-00930-9\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objectives: </strong>This study aimed to evaluate the diagnostic performance of simultaneous multislice (SMS) acquisition combined with monoexponential, intravoxel incoherent motion (IVIM), and diffusion kurtosis imaging (DKI) models for predicting microvascular invasion (MVI) and histologic grade in hepatocellular carcinoma (HCC).</p><p><strong>Materials and methods: </strong>A prospective study was conducted with 77 HCC patients. Diffusion-weighted imaging (DWI), IVIM, and DKI were performed on a 3T MRI using both SMS and conventional sequences. The values of diffusion parameters (ADC, D, D*, f, MD, and MK) were compared among SMS and conventional sequences, between MVI-positive and MVI-negative groups, and between high-grade and low-grade HCC groups. Receiver operating characteristic (ROC) curves were used to assess the diagnostic performance of diffusion parameters in predicting MVI and histologic grade. Inter-reader consistency was evaluated using intraclass correlation coefficients (ICC).</p><p><strong>Results: </strong>Among the 77 patients, 29.9% were MVI-positive and 35.1% had high-grade HCC. SMS reduced scanning time by up to 44.44%. Most diffusion parameters were similar between SMS and conventional sequences, except for slightly lower ADC and f in SMS. MVI-positive and high-grade HCC cases showed lower ADC, D, D*, and MD values and higher MK values. The ICC ranged from 0.702 to 0.879. SMS-MK demonstrated the highest diagnostic performance with an AUC of 0.92 for MVI and 0.86 for histologic grade.</p><p><strong>Conclusions: </strong>SMS acquisition, integrated with IVIM and DKI, is a feasible imaging method for preoperative evaluation of MVI and histologic grade in HCC, offering a faster alternative to conventional methods without compromising diagnostic performance.</p>\",\"PeriodicalId\":9548,\"journal\":{\"name\":\"Cancer Imaging\",\"volume\":\"25 1\",\"pages\":\"113\"},\"PeriodicalIF\":3.5000,\"publicationDate\":\"2025-09-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12465415/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cancer Imaging\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1186/s40644-025-00930-9\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"ONCOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cancer Imaging","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s40644-025-00930-9","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ONCOLOGY","Score":null,"Total":0}
Performance of simultaneous multislice diffusion-weighted imaging using monoexponential, intravoxel incoherent motion, and diffusion kurtosis models: assessment of microvascular invasion and histologic grade in hepatocellular carcinoma.
Objectives: This study aimed to evaluate the diagnostic performance of simultaneous multislice (SMS) acquisition combined with monoexponential, intravoxel incoherent motion (IVIM), and diffusion kurtosis imaging (DKI) models for predicting microvascular invasion (MVI) and histologic grade in hepatocellular carcinoma (HCC).
Materials and methods: A prospective study was conducted with 77 HCC patients. Diffusion-weighted imaging (DWI), IVIM, and DKI were performed on a 3T MRI using both SMS and conventional sequences. The values of diffusion parameters (ADC, D, D*, f, MD, and MK) were compared among SMS and conventional sequences, between MVI-positive and MVI-negative groups, and between high-grade and low-grade HCC groups. Receiver operating characteristic (ROC) curves were used to assess the diagnostic performance of diffusion parameters in predicting MVI and histologic grade. Inter-reader consistency was evaluated using intraclass correlation coefficients (ICC).
Results: Among the 77 patients, 29.9% were MVI-positive and 35.1% had high-grade HCC. SMS reduced scanning time by up to 44.44%. Most diffusion parameters were similar between SMS and conventional sequences, except for slightly lower ADC and f in SMS. MVI-positive and high-grade HCC cases showed lower ADC, D, D*, and MD values and higher MK values. The ICC ranged from 0.702 to 0.879. SMS-MK demonstrated the highest diagnostic performance with an AUC of 0.92 for MVI and 0.86 for histologic grade.
Conclusions: SMS acquisition, integrated with IVIM and DKI, is a feasible imaging method for preoperative evaluation of MVI and histologic grade in HCC, offering a faster alternative to conventional methods without compromising diagnostic performance.
Cancer ImagingONCOLOGY-RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
CiteScore
7.00
自引率
0.00%
发文量
66
审稿时长
>12 weeks
期刊介绍:
Cancer Imaging is an open access, peer-reviewed journal publishing original articles, reviews and editorials written by expert international radiologists working in oncology.
The journal encompasses CT, MR, PET, ultrasound, radionuclide and multimodal imaging in all kinds of malignant tumours, plus new developments, techniques and innovations. Topics of interest include:
Breast Imaging
Chest
Complications of treatment
Ear, Nose & Throat
Gastrointestinal
Hepatobiliary & Pancreatic
Imaging biomarkers
Interventional
Lymphoma
Measurement of tumour response
Molecular functional imaging
Musculoskeletal
Neuro oncology
Nuclear Medicine
Paediatric.