中性粒细胞胞外陷阱在心血管疾病中的病理作用和治疗意义。

IF 4.8 2区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biomolecules Pub Date : 2025-09-01 DOI:10.3390/biom15091263

Yan Ma, Jun Zhang, Yaxuan Qi, Yating Lu, Yalan Dong, Desheng Hu

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引用次数: 0

摘要

心血管疾病（CVD）目前被认为是对人类健康的主要威胁之一。中性粒细胞在先天免疫应答中起重要作用。中性粒细胞的激活导致中性粒细胞胞外陷阱（NETs）的释放，以响应各种刺激。适当的net对于维持体内稳态至关重要，而过多的net则会造成病理性损害。越来越多的证据表明，NETs与CVD病理生理有关。本文旨在全面回顾NETs的特征、信号通路和与其他免疫细胞的相互作用，并比较NETs与其他细胞死亡的关系，重点介绍NETs在心血管疾病中的作用。此外，本研究为进一步完善CVD的靶向NET治疗提供了理论依据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Neutrophil Extracellular Traps in Cardiovascular Diseases: Pathological Roles and Therapeutic Implications.

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Neutrophil Extracellular Traps in Cardiovascular Diseases: Pathological Roles and Therapeutic Implications.

Cardiovascular disease (CVD) is currently recognized as one of the leading health threats to humanity. Neutrophils play an important role in innate immune response. The activation of neutrophils leads to the release of neutrophil extracellular traps (NETs) in response to various stimuli. Appropriate NETs are essential for maintaining homeostasis in the body, while excessive NETs will cause pathological damage. Accumulating evidence indicates that NETs are implicated in CVD pathophysiology. This review aims to provide a comprehensive review of the characteristics, signaling pathways, and interactions of NETs with other immune cells, and the comparisons of NETosis with other cell deaths, focusing on the role of NETs in CVDs. Furthermore, this study provides a theoretical basis for further improvement in targeted NET therapy for CVD.

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来源期刊

Biomolecules Biochemistry, Genetics and Molecular Biology-Molecular Biology

CiteScore

9.40

自引率

3.60%

发文量

1640

审稿时长

18.28 days

期刊介绍： Biomolecules (ISSN 2218-273X) is an international, peer-reviewed open access journal focusing on biogenic substances and their biological functions, structures, interactions with other molecules, and their microenvironment as well as biological systems. Biomolecules publishes reviews, regular research papers and short communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced.