基于oct的疾病诊断综述:从特征提取方法到鲁棒安全框架。

IF 3.7 3区 医学 Q2 ENGINEERING, BIOMEDICAL
Alex Liew, Sos Agaian
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引用次数: 0

摘要

光学相干断层扫描(OCT)是诊断视网膜疾病的主要成像技术,如年龄相关性黄斑变性和糖尿病性视网膜病变。它能够检测结构变化,特别是视神经头部的结构变化,这对于早期诊断和监测至关重要。本文综述了使用OCT进行眼部疾病预测的技术,重点是手工制作和基于深度学习的特征提取器。虽然该领域发展迅速,但缺乏对这些方法的详细比较分析。我们通过回顾过去20年的研究,基于准确性、敏感性、特异性和计算成本评估方法来解决这个问题。检查的主要疾病包括青光眼、糖尿病视网膜病变、白内障、弱视和黄斑变性。我们还评估了广泛用于模型开发的公共OCT数据集。本文的一个独特贡献是探索针对基于oct的诊断系统的对抗性攻击和不同特征提取技术的漏洞。我们提出了一种实用的、强大的防御策略,该策略与现有模型集成并优于当前解决方案。我们的研究结果强调了经典和深度学习方法与强大防御相结合的价值,以提高基于oct的诊断的安全性和可靠性,我们为未来的研究和临床整合提供了指导。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Comprehensive Survey of OCT-Based Disorders Diagnosis: From Feature Extraction Methods to Robust Security Frameworks.

Optical coherence tomography (OCT) is a leading imaging technique for diagnosing retinal disorders such as age-related macular degeneration and diabetic retinopathy. Its ability to detect structural changes, especially in the optic nerve head, has made it vital for early diagnosis and monitoring. This paper surveys techniques for ocular disease prediction using OCT, focusing on both hand-crafted and deep learning-based feature extractors. While the field has seen rapid growth, a detailed comparative analysis of these methods has been lacking. We address this by reviewing research from the past 20 years, evaluating methods based on accuracy, sensitivity, specificity, and computational cost. Key diseases examined include glaucoma, diabetic retinopathy, cataracts, amblyopia, and macular degeneration. We also assess public OCT datasets widely used in model development. A unique contribution of this paper is the exploration of adversarial attacks targeting OCT-based diagnostic systems and the vulnerabilities of different feature extraction techniques. We propose a practical, robust defense strategy that integrates with existing models and outperforms current solutions. Our findings emphasize the value of combining classical and deep learning methods with strong defenses to enhance the security and reliability of OCT-based diagnostics, and we offer guidance for future research and clinical integration.

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来源期刊
Bioengineering
Bioengineering Chemical Engineering-Bioengineering
CiteScore
4.00
自引率
8.70%
发文量
661
期刊介绍: Aims Bioengineering (ISSN 2306-5354) provides an advanced forum for the science and technology of bioengineering. It publishes original research papers, comprehensive reviews, communications and case reports. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. All aspects of bioengineering are welcomed from theoretical concepts to education and applications. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. There are, in addition, four key features of this Journal: ● We are introducing a new concept in scientific and technical publications “The Translational Case Report in Bioengineering”. It is a descriptive explanatory analysis of a transformative or translational event. Understanding that the goal of bioengineering scholarship is to advance towards a transformative or clinical solution to an identified transformative/clinical need, the translational case report is used to explore causation in order to find underlying principles that may guide other similar transformative/translational undertakings. ● Manuscripts regarding research proposals and research ideas will be particularly welcomed. ● Electronic files and software regarding the full details of the calculation and experimental procedure, if unable to be published in a normal way, can be deposited as supplementary material. ● We also accept manuscripts communicating to a broader audience with regard to research projects financed with public funds. Scope ● Bionics and biological cybernetics: implantology; bio–abio interfaces ● Bioelectronics: wearable electronics; implantable electronics; “more than Moore” electronics; bioelectronics devices ● Bioprocess and biosystems engineering and applications: bioprocess design; biocatalysis; bioseparation and bioreactors; bioinformatics; bioenergy; etc. ● Biomolecular, cellular and tissue engineering and applications: tissue engineering; chromosome engineering; embryo engineering; cellular, molecular and synthetic biology; metabolic engineering; bio-nanotechnology; micro/nano technologies; genetic engineering; transgenic technology ● Biomedical engineering and applications: biomechatronics; biomedical electronics; biomechanics; biomaterials; biomimetics; biomedical diagnostics; biomedical therapy; biomedical devices; sensors and circuits; biomedical imaging and medical information systems; implants and regenerative medicine; neurotechnology; clinical engineering; rehabilitation engineering ● Biochemical engineering and applications: metabolic pathway engineering; modeling and simulation ● Translational bioengineering
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