揭示肠胰轴：微生物对PDAC干性和肿瘤微环境的影响。

IF 3.6 2区医学 Q2 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

STEM CELLS Pub Date : 2025-09-27 DOI:10.1093/stmcls/sxaf064

Kirtana Arikath, Surinder K Batra, Moorthy P Ponnusamy

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引用次数: 0

摘要

胰腺导管腺癌（Pancreatic ductal adenocarcinoma， PDAC）是一种侵袭性胰腺恶性肿瘤，以多种基因突变和代谢失调为特征。干细胞由于其可塑性、自我更新能力和驱动肿瘤发生的能力，在PDAC的启动、进展和抗性中起着关键作用。肠道微生物群是一个多样化的微生物生态系统，对全身健康，包括癌症的发展有着深远的影响。最近的研究强调，肿瘤内的微生物组组成可以通过塑造肿瘤微环境（tumor microenvironment， TME）、增强细胞可塑性和促进PDAC的干性特性来调节干细胞的行为。在这篇综述中，我们探讨了肠道微生物组和PDAC干细胞之间潜在的串扰，重点关注微生物组来源的信号如何影响干细胞维持、炎症、转移、TME调节和代谢重编程。

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Unveiling the Gut-Pancreas Axis: Microbial Influence on Stemness and Tumor Microenvironment of PDAC.

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive and malignant cancer of the pancreas characterized by various genetic mutations and metabolic dysregulations. Stem cells play a critical role in the initiation, progression, and resistance of PDAC due to their plasticity, self-renewal capabilities, and ability to drive tumorigenesis. The gut microbiome, a diverse ecosystem of microorganisms, has a profound influence on systemic health, including the development of cancer. Recent studies have highlighted that the microbiome composition within the tumor can modulate stem cell behavior by shaping the tumor microenvironment (TME), enhancing cellular plasticity, and promoting the stemness properties of PDAC. In this review, we explore the potential crosstalk between the gut microbiome and PDAC stem cells, focusing on how microbiome-derived signals impact stem cell maintenance, inflammation, metastasis, TME modulation, and metabolic reprogramming.

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来源期刊

STEM CELLS 医学-生物工程与应用微生物

CiteScore

10.30

自引率

1.90%

发文量

104

审稿时长

3 months

期刊介绍： STEM CELLS, a peer reviewed journal published monthly, provides a forum for prompt publication of original investigative papers and concise reviews. STEM CELLS is read and written by clinical and basic scientists whose expertise encompasses the rapidly expanding fields of stem and progenitor cell biology. STEM CELLS covers: Cancer Stem Cells, Embryonic Stem Cells/Induced Pluripotent Stem (iPS) Cells, Regenerative Medicine, Stem Cell Technology: Epigenetics, Genomics, Proteomics, and Metabonomics, Tissue-Specific Stem Cells, Translational and Clinical Research.