Carlos Vinicius F. da Silva, Carlos José F. da Silva, Thaís R. Cataldi, Carlos A. Labate, Youssef B. Sade, Sandra Mara N. Scapin, Fabiano L. Thompson, Cristiane Thompson, Carina Maciel da Silva-Boghossian, Eidy de Oliveira Santos
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A subset, including DMBT1, Vanin-1, PTPRJ, <i>β</i>-hydroxybutyrate, <i>α</i>-tocopherol, and 5-oxoproline, emerged as potential key players associated with obesity and MetS. 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A subset, including DMBT1, Vanin-1, PTPRJ, <i>β</i>-hydroxybutyrate, <i>α</i>-tocopherol, and 5-oxoproline, emerged as potential key players associated with obesity and MetS. 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Proteomic and Metabolomic Interplay in the Regulation of Energy Metabolism During Obesity and Metabolic Syndrome
Aim
Explore the influence of obesity and Metabolic Syndrome disorders on the plasma proteome and metabolome, through an integrated analysis.
Materials and Methods
We investigated metabolic and proteomic alterations associated with obesity and MetS, through mass spectrometry, using plasma samples from 49 volunteers, categorized according to BMI, and MetS.
Results
We identified 231 proteins and 77 metabolites. A subset, including DMBT1, Vanin-1, PTPRJ, β-hydroxybutyrate, α-tocopherol, and 5-oxoproline, emerged as potential key players associated with obesity and MetS. By integrating proteomic and metabolomic data, we were able to construct an interactive network involved in metabolic dysfunction, revealing associations between these molecules and clinical parameters, such as BMI, HOMA-IR and HOMA-β.
Conclusions
Our data suggested an interplay between anti-inflammatory (DMBT1, 3-hydroxybutyrate, 5-oxoproline) and pro-inflammatory pathways (Vanin-1, α-tocopherol, PTPRJ) during disorders of obesity and MetS, demonstrating the potential of an integrated multi-omics approach for a better understanding of the mechanism behind obesity-associated metabolic diseases.
期刊介绍：
Diabetes/Metabolism Research and Reviews is a premier endocrinology and metabolism journal esteemed by clinicians and researchers alike. Encompassing a wide spectrum of topics including diabetes, endocrinology, metabolism, and obesity, the journal eagerly accepts submissions ranging from clinical studies to basic and translational research, as well as reviews exploring historical progress, controversial issues, and prominent opinions in the field. Join us in advancing knowledge and understanding in the realm of diabetes and metabolism.
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