完全物理增强的水凝胶:一个定期姜黄素输送系统,方便注射和热可逆粘附

IF 2.3 4区 化学 Q3 CHEMISTRY, PHYSICAL
Jingyan Zhang, Zhengkai Wang, Yuxing Yue, Yishuo Ning, Pengyuan Xu, Weixiang Fan, Han Xuan, Haiou Zhou, Mei Sun, Xianbiao Wang, Ping Wang, Mingdi Yang
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引用次数: 0

摘要

具有完全物理网络的水凝胶具有注射方便、自愈和可生物降解等显著优点,但其力学、粘附性和载药特性可能不利。本研究采用简便的一步Michael加成法合成了N′-(2-硝基苯基)(NB)修饰的N-丙烯酰甘氨酸酰胺(NAGA)接枝明胶。通过紫外诱导NB基团分离和双酰胺放电,方便地构建了具有明胶物理增强作用的GN水凝胶。姜黄素类药物也通过疏水缔合进入疏水NB基团。对一系列不同取代度的GN水凝胶进行了对比分析。结果表明,中等DS(~ 41.2±1.3%)的GN-5水凝胶具有最高的最终储存模量、最大的压缩应力、最致密的孔隙结构和最小的膨胀变形。此外,全物理网络完全有助于降解,快速自愈和热可逆粘附性。最重要的是,姜黄素的进一步释放是通过加热诱导h键破坏实现的,而Ritger-Peppas模型最能描述四种动力学模型中药物的动态释放轨迹,在生物医学材料领域显示出巨大的应用潜力。摘要完全物理增强的明胶水凝胶具有注射方便、自愈快、降解彻底、热可逆粘附等特点,可作为姜黄素的周期性输送系统。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Fully physically reinforced hydrogels: a periodic curcumin delivery system with convenient injection and thermo-reversible adhesion

Hydrogels with fully physical networks process significant advantages as convenient injection, self-healing, and biodegradable properties probably accompanied with unfavorable mechanics, adhesiveness, and drug-loading characteristics. In this study, N-acryloyl glycinamide (NAGA)–grafted gelatin decorated with photosensitive N′-(2-nitrobenzyl) (NB) moiety, denoted as GN, was synthesized via a convenient one-step Michael addition. The GN hydrogels in terms of gelatin physical reinforcement was conveniently constructed via UV-induced NB group separation and dual-amide discharge. Also released are curcumin drugs loaded into hydrophobic NB groups via hydrophobic association. Contrastive analysis on a series of GN hydrogels with different degrees of substitution (DS) was performed. As a result, the GN-5 hydrogel with moderate DS (~ 41.2 ± 1.3%) possessed the overall optimal performance with the highest final storage modulus, maximal compression stress, most dense pore structure, and minimal swelling deformation. In addition, the fully physical networks thoroughly assisted in degradation, fast self-healing, and thermo-reversible adhesiveness. Most importantly, the further curcumin release achieved via heating induced H-bonding destruction, and the Ritger-Peppas model best described the dynamic drug release traces during the four kinetic models, which show great application potential in the field of biomedical materials.

Graphical Abstract

The fully physically reinforced gelatin hydrogels afford as a periodic curcumin delivery system with convenient injection, fast self-healing, thoroughly degradation, and thermo-reversible adhesion. 

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来源期刊
Colloid and Polymer Science
Colloid and Polymer Science 化学-高分子科学
CiteScore
4.60
自引率
4.20%
发文量
111
审稿时长
2.2 months
期刊介绍: Colloid and Polymer Science - a leading international journal of longstanding tradition - is devoted to colloid and polymer science and its interdisciplinary interactions. As such, it responds to a demand which has lost none of its actuality as revealed in the trends of contemporary materials science.
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