液体培养基中乳酸菌表面声波传感器的设计与表征

IF 3.3 4区 医学 Q3 ENGINEERING, BIOMEDICAL
M. Rizwan Ali, Sohail Iqbal, Liangliang Fan, Rana Iqtidar Shakoor, Liang Zhao
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引用次数: 0

摘要

表面声波(SAW)传感器是用于微粒子检测的关键微机电系统(MEMS)器件,具有紧凑的设计、高通量和低制造成本。本工作介绍了一种SAW传感器的设计、制造和表征,该传感器采用聚二甲基硅氧烷(PDMS)微流体通道作为双功能波导,有效地定位Love波(LW)约束并将瑞利波转换为LW。利用多参数有限元分析(FEA)、分析建模和实验验证相结合的综合方法,开发了两种具有不同交叉换能器(IDT)电极配置(宽度和间距分别为12 μm和38 μm)的SAW器件。有限元分析和实验结果一致证实了12 μm电极结构的优越性能。该器件实现了显著的BAW抑制,其插入损耗(S21)低至-57 dB (FEA),导纳峰窄(Δf = 0.6 MHz),中心频率(fc = 82.5 MHz)处q因子高。12 μm电极配置的性能指标包括反射系数(S11)为-85 × 10⁻⁷dB (38 μm为-40 × 10⁻⁸dB),实验插入损失分别为-64.86 dB, -67.05 dB和- 69.27 dB,手指对数较高时的低检测极限(LoD)。PDMS波导最大限度地限制了表面的声能,实现了高效的Love波传播,从而最大限度地减少了液体中的耗散损失。此外,在y方向上的主导位移为0.026 μm,并且有较高的导纳峰(80 × 10⁻),分别表明在液体介质中具有高灵敏度和高质量(Q)因子。该传感器的微颗粒检测能力,基于监测IL的变化,建立了一个有效的指标,用于量化颗粒诱导的扰动在流动配置中,在不同的颗粒浓度,已经使用10 μm直径的聚苯乙烯(PS)颗粒作为乳酸杆菌类似物进行了实验验证。分析、有限元分析和实验结果之间的强烈一致性验证了这种具有集成微流体的高保真SAW设备是一种有前途的、经济高效的、高灵敏度的液体介质中微粒检测平台,如果不使用任何波导,则有可能扩展到气体传感应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Design and characterization of surface acoustic wave (SAW) sensor for detection of Lactobacillus in liquid medium

Design and characterization of surface acoustic wave (SAW) sensor for detection of Lactobacillus in liquid medium

Surface Acoustic Wave (SAW) sensors are pivotal Micro-Electrical-Mechanical Systems (MEMS) devices for micro-particle detection, offering compact design, high throughput, and low fabrication cost. This work presents the design, fabrication, and characterization of a SAW sensor employing a Polydimethylsiloxane (PDMS) microfluidic channel as a dual-function waveguide to effectively localize Love Wave (LW) confinement and convert Rayleigh waves to LW. Utilizing a comprehensive approach integrating multi-parametric Finite Element Analysis (FEA), analytical modeling, and experimental validation, two SAW devices with distinct interdigitated transducer (IDT) electrode configurations (12 μm and 38 μm width and spacing) have been developed. FEA and experimental results consistently confirm the superior performance of the 12 μm electrode configuration. This device achieved significant BAW suppression, evidenced by a low insertion loss (S21) of -57 dB (FEA) and a narrow admittance peak (Δf = 0.6 MHz at FWHM), yielding a high Q-factor at its center frequency (fc = 82.5 MHz). Performance metrics for the 12 μm electrode configuration include a reflection coefficient (S11) of -85 × 10⁻⁷ dB (vs. -40 × 10⁻⁸ dB for 38 μm), experimental insertion losses of -64.86 dB, -67.05 dB, and − 69.27 dB for 50, 40, and 30 finger pairs respectively, and low limit of detection (LoD) with higher number of finger pairs. The PDMS waveguide maximized acoustic energy confinement at the surface, enabling efficient Love wave propagation, which minimizes dissipative losses in Liquids. Moreover, the dominant y-direction surface displacement of 0.026 μm, and a higher admittance peak (80 × 10⁻⁷), indicating high sensitivity in liquid medium and high quality (Q) factor, respectively. The sensor’s micro-particle detection capability, based on monitoring IL changes – established as an effective metric for quantifying particle-induced perturbations in flow-through configurations – across varying particle concentrations, has been experimentally validated using 10 μm diameter Polystyrene (PS) particles as Lactobacillus analogs. The strong agreement between analytical, FEA, and experimental results validates this high-fidelity SAW device with integrated microfluidics as a promising, cost-effective, and highly sensitive platform for micro-particle detection in liquid media, with potential extension to gas sensing applications, if used without any waveguide.

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来源期刊
Biomedical Microdevices
Biomedical Microdevices 工程技术-工程:生物医学
CiteScore
6.90
自引率
3.60%
发文量
32
审稿时长
6 months
期刊介绍: Biomedical Microdevices: BioMEMS and Biomedical Nanotechnology is an interdisciplinary periodical devoted to all aspects of research in the medical diagnostic and therapeutic applications of Micro-Electro-Mechanical Systems (BioMEMS) and nanotechnology for medicine and biology. General subjects of interest include the design, characterization, testing, modeling and clinical validation of microfabricated systems, and their integration on-chip and in larger functional units. The specific interests of the Journal include systems for neural stimulation and recording, bioseparation technologies such as nanofilters and electrophoretic equipment, miniaturized analytic and DNA identification systems, biosensors, and micro/nanotechnologies for cell and tissue research, tissue engineering, cell transplantation, and the controlled release of drugs and biological molecules. Contributions reporting on fundamental and applied investigations of the material science, biochemistry, and physics of biomedical microdevices and nanotechnology are encouraged. A non-exhaustive list of fields of interest includes: nanoparticle synthesis, characterization, and validation of therapeutic or imaging efficacy in animal models; biocompatibility; biochemical modification of microfabricated devices, with reference to non-specific protein adsorption, and the active immobilization and patterning of proteins on micro/nanofabricated surfaces; the dynamics of fluids in micro-and-nano-fabricated channels; the electromechanical and structural response of micro/nanofabricated systems; the interactions of microdevices with cells and tissues, including biocompatibility and biodegradation studies; variations in the characteristics of the systems as a function of the micro/nanofabrication parameters.
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