{"title":"对盐酸利多卡因和盐酸地尔硫卓分析方法的重要见解：比较回顾","authors":"Shivani Patel, Archita Patel, Chandni Chandarana, Bhavesh Patel, Mehul Patel, Umang Shah, Swayamprakash Patel, Nilay Solanki, Drashti Shah, Ashish Patel","doi":"10.1186/s43094-025-00852-0","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>This study focuses on a fixed-dose combination of lidocaine hydrochloride and diltiazem hydrochloride for the treatment of anal fissures, where lidocaine acts as an anesthetic and diltiazem serves as a slow calcium channel blocker. The objective is to provide a concise overview of the fundamental principles of spectrophotometric and chromatographic methods for quantitative analysis from 2012 to 2022.</p><h3>Main text</h3><p>This review highlights the development of novel techniques for both individual and simultaneous quantification, including ultraviolet–visible spectrophotometry (UV–Vis), high-performance liquid chromatography, and high-performance thin-layer chromatography. Additionally, it addresses the capability of various analytical methods to detect and measure compounds at microgram to nanogram levels.</p><h3>Conclusions</h3><p>From 2012 to 2022, significant advancements in spectrophotometric and chromatographic methods for analyzing pharmaceutical compounds such as lidocaine and diltiazem have been made. These advancements have improved the sensitivity, accuracy, and efficiency of quantitative analyses, contributing to better quality control and therapeutic efficacy of pharmaceutical products. Modern techniques can detect and quantify compounds at microgram to nanogram levels, ensuring accurate dosing and safety assessments in pharmaceutical formulations.</p></div>","PeriodicalId":577,"journal":{"name":"Future Journal of Pharmaceutical Sciences","volume":"11 1","pages":""},"PeriodicalIF":3.0000,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://fjps.springeropen.com/counter/pdf/10.1186/s43094-025-00852-0","citationCount":"0","resultStr":"{\"title\":\"Critical insights into analytical methodologies for lidocaine hydrochloride and diltiazem hydrochloride: a comparative review\",\"authors\":\"Shivani Patel, Archita Patel, Chandni Chandarana, Bhavesh Patel, Mehul Patel, Umang Shah, Swayamprakash Patel, Nilay Solanki, Drashti Shah, Ashish Patel\",\"doi\":\"10.1186/s43094-025-00852-0\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><p>This study focuses on a fixed-dose combination of lidocaine hydrochloride and diltiazem hydrochloride for the treatment of anal fissures, where lidocaine acts as an anesthetic and diltiazem serves as a slow calcium channel blocker. The objective is to provide a concise overview of the fundamental principles of spectrophotometric and chromatographic methods for quantitative analysis from 2012 to 2022.</p><h3>Main text</h3><p>This review highlights the development of novel techniques for both individual and simultaneous quantification, including ultraviolet–visible spectrophotometry (UV–Vis), high-performance liquid chromatography, and high-performance thin-layer chromatography. Additionally, it addresses the capability of various analytical methods to detect and measure compounds at microgram to nanogram levels.</p><h3>Conclusions</h3><p>From 2012 to 2022, significant advancements in spectrophotometric and chromatographic methods for analyzing pharmaceutical compounds such as lidocaine and diltiazem have been made. These advancements have improved the sensitivity, accuracy, and efficiency of quantitative analyses, contributing to better quality control and therapeutic efficacy of pharmaceutical products. Modern techniques can detect and quantify compounds at microgram to nanogram levels, ensuring accurate dosing and safety assessments in pharmaceutical formulations.</p></div>\",\"PeriodicalId\":577,\"journal\":{\"name\":\"Future Journal of Pharmaceutical Sciences\",\"volume\":\"11 1\",\"pages\":\"\"},\"PeriodicalIF\":3.0000,\"publicationDate\":\"2025-07-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://fjps.springeropen.com/counter/pdf/10.1186/s43094-025-00852-0\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Future Journal of Pharmaceutical Sciences\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://link.springer.com/article/10.1186/s43094-025-00852-0\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"PHARMACOLOGY & PHARMACY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Future Journal of Pharmaceutical Sciences","FirstCategoryId":"1085","ListUrlMain":"https://link.springer.com/article/10.1186/s43094-025-00852-0","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
Critical insights into analytical methodologies for lidocaine hydrochloride and diltiazem hydrochloride: a comparative review
Background
This study focuses on a fixed-dose combination of lidocaine hydrochloride and diltiazem hydrochloride for the treatment of anal fissures, where lidocaine acts as an anesthetic and diltiazem serves as a slow calcium channel blocker. The objective is to provide a concise overview of the fundamental principles of spectrophotometric and chromatographic methods for quantitative analysis from 2012 to 2022.
Main text
This review highlights the development of novel techniques for both individual and simultaneous quantification, including ultraviolet–visible spectrophotometry (UV–Vis), high-performance liquid chromatography, and high-performance thin-layer chromatography. Additionally, it addresses the capability of various analytical methods to detect and measure compounds at microgram to nanogram levels.
Conclusions
From 2012 to 2022, significant advancements in spectrophotometric and chromatographic methods for analyzing pharmaceutical compounds such as lidocaine and diltiazem have been made. These advancements have improved the sensitivity, accuracy, and efficiency of quantitative analyses, contributing to better quality control and therapeutic efficacy of pharmaceutical products. Modern techniques can detect and quantify compounds at microgram to nanogram levels, ensuring accurate dosing and safety assessments in pharmaceutical formulations.
期刊介绍：
Future Journal of Pharmaceutical Sciences (FJPS) is the official journal of the Future University in Egypt. It is a peer-reviewed, open access journal which publishes original research articles, review articles and case studies on all aspects of pharmaceutical sciences and technologies, pharmacy practice and related clinical aspects, and pharmacy education. The journal publishes articles covering developments in drug absorption and metabolism, pharmacokinetics and dynamics, drug delivery systems, drug targeting and nano-technology. It also covers development of new systems, methods and techniques in pharmacy education and practice. The scope of the journal also extends to cover advancements in toxicology, cell and molecular biology, biomedical research, clinical and pharmaceutical microbiology, pharmaceutical biotechnology, medicinal chemistry, phytochemistry and nutraceuticals.
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